Denis R. Benjamin

Botanical Research Institute of Texas

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Joseph R. Siebert

University of Washington

Jonathan D. Buckley

University of South Australia

Arnold L. Smith

Royal Children's Hospital

C. George Ray

Cardinal Glennon Children’s Medical Center

Richard F. Jacobs

University of Arkansas for Medical Sciences

Robert J. Wells

The University of Texas MD Anderson Cancer Center

Philip L. Glick

University at Buffalo, State University of New York

Irwin D. Bernstein

Fred Hutch Cancer Center

Beatrice C. Lampkin

University of Cincinnati

Joseph R. Siebert

Seattle Children's Hospital

Cooperative Institutions

University of Washington

Seattle Children's Hospital

Seattle University

Children's Hospital & Medical Center

Boston Children's Hospital

Fred Hutch Cancer Center

National Institutes of Health

Pediatrics and Genetics

University of Southern California

Neurological Surgery

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The “Third Wave” Laboratory

American Journal of Clinical Pathology (1982)

Denis R. Benjamin

Certain aspects of the future role, organization, and relationship of the clinical laboratory are evaluated based on the futurist concepts of Alvin. Toffler. These include the developing trends towards decentralization, customization, and increasing diversity within the laboratory. In order to facilitate these changes, the computer will play an increasingly important role, moving information into and but of the laboratory. Possible changes in the orientation and functions of medical technologists are proposed that could have significant implications in terms of their future training and relationships with the medical and nursing staff.

Futurist

National laboratory

10.1093/ajcp/78.3.324

Cite

Citations (1)

Editorial: Reengineering the Clinical Laboratory

Pediatric Pathology & Laboratory Medicine (1997)

Denis R. Benjamin

Business process reengineering

10.1080/15513819709168342

Cite

Citations (1)

Elevated values of tri-iodothyronine in victims of sudden infant death syndrome

The Journal of Pediatrics (1982)

Denis R. Benjamin J. Bruce Beckwith

10.1016/s0022-3476(82)80621-5

Cite

Citations (2)

Physicians as Historians

Pediatric and Developmental Pathology (2000)

Denis R. Benjamin

10.1007/s100240010042

Cite

Citations (1)

Pediatric Laboratory Practice

American Journal of Clinical Pathology (1995)

Denis R. Benjamin

Journal Article Pediatric Laboratory Practice Get access Denis R. Benjamin, MB, BCH Denis R. Benjamin, MB, BCH Children's Hospital and Medical Center University of Washington School of Medicine Seattle, Washington Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 104, Issue 3, 1 September 1995, Pages 237–238, https://doi.org/10.1093/ajcp/104.3.237 Published: 01 September 1995

10.1093/ajcp/104.3.237

Cite

Citations (0)

Biologic Characteristics and Treatment of Acute Nonlymphocytic Leukemia in Children: Report of the ANLL Strategy Group of the Childrens Cancer Study Group

Pediatric Clinics of North America (1988)

Beatrice C. Lampkin Beverly J. Lange Irwin D. Bernstein William G. Woods Lorrie F. Odom

10.1016/s0031-3955(16)36508-7

Cite

Citations (21)

Proliferating Cell Nuclear Antigen (PCNA) and Pediatric Tumors: Assessment of Proliferative Activity

Pediatric Pathology (1991)

Denis R. Benjamin

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA) were used to detect proliferating cells in pediatric tumors fixed in Carnoy's solution. The percentage of staining cells was quantified using image analysis and compared to the S + G2M phase fraction as determined by flow cytometry. Although there was a general correlation between these indices of cellular proliferation, some variation was noted between tumor systems as well as within a specific tumor type. In some cases this variation was easily explicable by the morphologic findings (e.g., tumor heterogeneity and sampling differences, stromal cell proliferation, necrosis, extramedullary hematopoiesis), whereas in others it appeared to be an intrinsic property of the cell line. It is concluded that PCNA immunostaining is a useful and reproducible method of assessing one aspect of cellular proliferative activity and especially of addressing the questions, “which cells are dividing and where?” It has some advantages over flow cytometry in that it maintains tissue integrity and morphologic relationships.

Immunostaining

10.3109/15513819109064787

Cite

Citations (19)

Use of Immunoperoxidase on Brain Tissue for the Rapid Diagnosis of Herpes Encephalitis

American Journal of Clinical Pathology (1975)

Denis R. Benjamin C. George Ray

An indirect immunoperoxidase method to detect herpes simplex viral antigen in brain cell suspensions from patients suspected to have herpes encephalitis is described. The method is rapid, reliable and specific, and successfully identified the herpes virus infected cells in four of five culture-proven cases. There was one false-negative reaction, but no false-positive. The immunoperoxidase technic offers a number of advantages over immunofluorescence for routine diagnosis.

Immunoperoxidase

Immunofluorescence

Simplexvirus

10.1093/ajcp/64.4.472

Cite

Citations (26)

Use of Immunoperoxidase for the Rapid Identification of Human Myxoviruses and Paramyxoviruses in Tissue Culture

Applied Microbiology (1974)

Denis R. Benjamin C. George Ray

The immunoperoxidase method, using commercially available antisera, was compared with standard virological methods for the identification and typing of 77 isolates of human myxoviruses and paramyxoviruses. Results of typing using neutralization tests and the immunoperoxidase technique were identical for 76 of the 77 isolates. With the immunoperoxidase method there was one false negative reaction, but no false positive reactions. Cross-reactivity between influenza A (soluble) and A 2 /HK antisera with influenza A isolates was noted, but did not interfere with the interpretation of results. It is concluded that the immunoperoxidase method is ideally suited for the rapid identification and typing of common human respiratory viruses on a routine basis. It offers a number of decided advantages over both immunofluorescence and standard virological methods.

Immunoperoxidase

Immunofluorescence

Identification

10.1128/am.28.1.47-51.1974

Cite

Citations (23)

Acute Renal Failure Associated with Suspected Amanita smithiana Mushroom Ingestions: A Case Series

Academic Emergency Medicine (1998)

Craig R. Warden Denis R. Benjamin

Abstract. Mushroom poisoning leading to acute renal failure is extremely rare in North America. Cortinarius species and Amanita smithiana both can cause acute renal failure and inhabit the Pacific northwest. This article describes 4 patients who presented in acute renal failure and who ingested mushrooms described as resembling A. smithiana. Two patients (a 74‐year‐old Korean couple) described eating mushrooms with an approximately 6 × 0.5‐inch stipe with a white cap, 1.25‐1.5 inches in diameter. The other 2 patients (a 55‐year‐old male and a 30‐year‐old female) also described a white‐capped mushroom. All believed they were eating the matsutake (Tricho‐loma magnivalere) mushroom, which can be mistaken for A. smithiana. Onset of gastrointestinal symptoms ranged from 20 minutes to 12 hours, and presentation in acute renal failure ranged from 4 to 6 days postingestion (initial BUN and creatinine were 72–91 mg/dL and 12–13.9 mg/dL, respectively). One patient had underlying mild renal insufficiency and one had hypertension that was under control, while the others had no risk factors for renal disease. None had any other explanation for the episode of acute renal failure. All underwent acute hemodialysis for at least several weeks, eventually returning to baseline renal function.

Mushroom poisoning

Stipe (mycology)

10.1111/j.1553-2712.1998.tb02508.x

Cite

Citations (45)