Steven M. Schrader

National Institute for Occupational Safety and Health

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Terry W. Turner

National Institute for Occupational Safety and Health

Brian D. Lowe

National Institute for Occupational Safety and Health

Michael Breitenstein

National Institute for Occupational Safety and Health

Robert E. Chapin

Pfizer (United States)

Sally D. Perreault

Environmental Protection Agency

T. W. Turner

National Institute for Occupational Safety and Health

Anne Sweeney

Ollscoil na Gaillimhe – University of Galway

David F. Katz

Duke University

Stephen D. Simon

University of Missouri–Kansas City

William J. Moorman

National Institute for Occupational Safety and Health

Cooperative Institutions

National Institute for Occupational Safety and Health

Centers for Disease Control and Prevention

Health Effects Institute

Medical Protective

Centre de Nanosciences et de Nanotechnologies

United States Department of Health and Human Services

National Institutes of Health

Johns Hopkins University

Environmental Protection Agency

National Institute of Environmental Health Sciences

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The Role of the Newspaper in a Disadvantaged School.

Steven M. Schrader

Disadvantaged

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Research on Bicycle Saddles and Sexual Health Comes of Age

The Journal of Sexual Medicine (2005)

Steven M. Schrader

10.1111/j.1743-6109.2005.00154_2.x

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Citations (6)

Biomarkers and Health Endpoints of Developmental Toxicology of Paternal Origin: Summary of Working Group Discussions

Springer eBooks (1994)

Andrew J. Wyrobek Diana Anderson Sandy Lewis Tetsuji Nagao Sally D. Perreault

10.1007/978-1-4615-1877-8_34

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Citations (2)

Paternal exposure of rabbits to lead: Behavioral deficits in offspring

Neurotoxicology and Teratology (1997)

B. K. Nelson William J. Moorman Steven M. Schrader Peter B. Shaw Edward F. Krieg

Litter

Lead acetate

Reproductive toxicity

Animal model

10.1016/s0892-0362(96)00221-8

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Citations (6)

Occupational Exposure to Acrylamide in Closed System Production Plants: Air Levels and Biomonitoring

Journal of Toxicology and Environmental Health (2011)

William J. Moorman Susan Simpson Reutman Peter B. Shaw L.M. Blade David Marlow

The aim of this study was to evaluate biomarkers of acrylamide exposure, including hemoglobin adducts and urinary metabolites in acrylamide production workers. Biomarkers are integrated measures of the internal dose, and it is total acrylamide dose from all routes and sources that may present health risks. Workers from three companies were studied. Workers potentially exposed to acrylamide monomer wore personal breathing-zone air samplers. Air samples and surface-wipe samples were collected and analyzed for acrylamide. General-area air samples were collected in chemical processing units and control rooms. Hemoglobin adducts were isolated from ethylenediamine teraacetic acid (EDTA)–whole blood, and adducts of acrylamide and glycidamide, at the N-terminal valines of hemoglobin, were cleaved from the protein chain by use of a modified Edman reaction. Full work-shift, personal breathing zone, and general-area air samples were collected and analyzed for particulate and acrylamide monomer vapor. The highest general-area concentration of acrylamide vapor was 350 μg/cm3 in monomer production. Personal breathing zone and general-area concentrations of acrylamide vapor were found to be highest in monomer production operations, and lower levels were in the polymer production operations. Adduct levels varied widely among workers, with the highest in workers in the monomer and polymer production areas. The acrylamide adduct range was 15–1884 pmol/g; glycidamide adducts ranged from 17.8 to 1376 p/mol/g. The highest acrylamide and glycidamide adduct levels were found among monomer production process operators. The primary urinary metabolite N-acetyl-S-(2-carbamoylethyl) cysteine (NACEC) ranged from the limit of detection to 15.4 μg/ml. Correlation of workplace exposure and sentinel health effects is needed to determine and control safe levels of exposure for regulatory standards.

Exposure Assessment

10.1080/15287394.2011.615109

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Citations (22)

Prospective pregnancy study designs for assessing reproductive and developmental toxicants.

Environmental Health Perspectives (2003)

Germaine M. Buck Louis Courtney D. Lynch Joseph B. Stanford Anne Sweeney Laura A. Schieve

The determinants of successful human reproduction and development may act as early as periconceptionally, underscoring the need to capture exposures during these critical windows when assessing potential toxicants. To identify such toxicants, couples must be studied longitudinally prior to conception without regard to a couple's ability to ascertain a clinically recognized pregnancy. We examined the utility and feasibility of prospective pregnancy study designs by conducting a systematic review of the literature to summarize relevant information regarding the planning, implementation, and success of previously published prospective pregnancy studies. Information concerning design elements and participation was abstracted from 15 eligible studies (from a total of 20 identified studies) using a standardized form. The primary author of each study was contacted to review our summary of their work and obtain missing information. Our findings confirm the ability to recruit women/couples from diverse populations using a variety of recruitment strategies. Among the studies we reviewed, 4-97% of eligible individuals were successfully contacted, with enrollment rates ranging from 42 to 100%. Length of follow-up varied from 3 to 12 months. A high percentage of women provided urine (57-98%) and blood (86-91%) specimens and most male partners (94-100%) provided semen samples. These data support the feasibility of this design.

Clinical study design

10.1289/ehp.6262

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Citations (77)

Biomarkers of ethylene dibromide (EDB) induced alterations of seminal plasma biochemistry as a function of post-testicular toxicity

Toxicology Letters (1998)

A. Zikarge Steven M. Schrader

Ethylene Dibromide

10.1016/s0378-4274(98)80759-5

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Current intelligence bulletin 70: health effects of occupational exposure to silver nanomaterials.

John J. Howard Eileen D. Kuempel Jenny R. Roberts Gary A. Roth Kevin Dunn

When the U.S

Nanomaterials

10.26616/nioshpub2021112

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Citations (14)

Male Reproductive Effects of Lead, Including Species Extrapolation for the Rabbit Model 11This work was supported in part by IA # YO1-ES-40266, from NIEHS, National Toxicology Program.

Reproductive Toxicology (1998)

William J. Moorman Stephen R. Skaggs John C. Clark Terry W. Turner Douglas D. Sharpnack

Reproductive toxicity

10.1016/s0890-6238(98)00010-0

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Citations (35)

Measuring Male Reproductive Hormones for Occupational Field Studies

Journal of Occupational and Environmental Medicine (1993)

Steven M. Schrader Terry W. Turner Michael Breitenstein Stephen D. Simon

As part of our longitudinal study of unexposed workers, we drew blood samples and analyzed the individual endocrine profiles for 45 men. The blood collection was between 8 AM and 8 PM, and three blood samples were drawn 20 minutes apart on three occasions during the course of the study (June, October, and February). Serum concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin were determined. A component of variance model was used to estimate variability between the 20-minute blood draws. Statistical power analysis using this component showed that three blood draws provide a marginal improvement over a single blood draw in detecting population shifts. Also, if the prospect of three blood draws reduces subject participation by 10 to 20%, the increase in power would be negated.

Blood collection

10.1097/00043764-199306000-00013

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Citations (26)