Hiroshi Tanooka

Japan Radioisotope Association

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Akira Ootsuyama

University of Occupational and Environmental Health Japan

Takahiro Ochiya

Tokyo Medical University

Kazuhiko Tanaka

Osaka University of Pharmaceutical Sciences

Akihiro Kaneko

Tokyo University of Science

Kouichi Tatsumi

Shinshu University

Masao S. Sasaki

Mitsui (Japan)

Tetsuji Nagao

Kindai University

Yosuke Ejima

The University of Texas Southwestern Medical Center

Kazuo Fujikawa

RIKEN

Kazuhiko Aoyagi

National Cancer Centre Japan

Cooperative Institutions

Heidelberg University

The University of Tokyo

German Cancer Research Center

DKFZ-ZMBH Alliance

National Cancer Research Institute

Kyoto University

National Cancer Centre Japan

University Hospital Heidelberg

National Institutes of Health

Tokyo University of Science

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Clonal origin of spontaneous multiple mammary tumors in mice with cellular mosaicism.

PubMed (1984)

Kazuhiko Tanaka Akira Ootsuyama Hiroshi Tanooka

The clonal origin of spontaneous multiple mammary tumors in mice was examined. For this purpose, hybrid female mice (Pgk-1b/Pgk-1a), F1[SHN(Pgk-1b) X C3H/He (Pgk-1a)], with X-chromosome inactivation mosaicism with regard to the phosphoglycerate kinase (PGK)-1 isozyme together with a high incidence of spontaneous mammary tumors were constructed. Thirty-seven of 45 mammary tumors (82%) in mosaic mice had a single phenotype of PGK, indicating monoclonal origin. The multiple mammary tumors formed in these mice varied in PGK type, indicating independent cellular origins.

Phosphoglycerate kinase

Mammary tumor

Ratón

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Application of a Newly Developed Photoluminescence Glass Dosimeter for Measuring the Absorbed Dose in Individual Mice Exposed to Low-dose Rate 137Cs γ-rays

Journal of Radiation Research (2000)

Yuko Hoshi Takaharu Nomura Takeshi Oda Toshiyasu Iwasaki Kazuko Fujita

A photoluminescence glass dosimeter, GD-301, was applied to the measurement of low absorbed doses in mice exposed to low-dose rate 137Cs gamma-rays. The dosimeter system consists of small rod-shaped glass chip detectors capable of embedded in the body of a mouse and an automatic readout device equipped with a standard detector irradiated with 137Cs gamma-source. The measured absorbed doses were compared with the "exposure" estimated by an ionization chamber and with the doses measured by a BeO:Na thermoluminescence system. The results clearly demonstrate the superiority of the glass dosimetry regarding simplicity of operation, stability of long-term dose accumulation and good detector uniformity, which allow accurate tissue dosimetry.

Dose rate

Dose profile

10.1269/jrr.41.129

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Citations (38)

Types, rates, origin and expressivity of chromosome mutations involving 13q14 in retinoblastoma patients

Human Genetics (1988)

Yoshimichi Ejima M.S. Sasaki Akihiro Kaneko Hiroshi Tanooka

Retinoblastoma

Chromosome 13

Human genetics

10.1007/bf00280548

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Citations (78)

Thermorestoration of Mutagenic Radiation Damage in Bacterial Spores

Science (1978)

Hiroshi Tanooka

The frequency of mutations in Bacillus subtilis spores irradiated anoxically with ionizing radiation decreased as a result of subsequent anoxic heating to the same extent as the increase in spore survival. This result indicates that DNA damage is the origin of the "thermorestoration" phenomenon.

Bacterial spore

10.1126/science.96526

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Citations (9)

Distribution of the p53 pseudogene among mouse species and subspecies

Mammalian Genome (1995)

Hiroshi Tanooka Akira Ootsuyama Toshihiko Shiroishi Kenta Moriwaki

Pseudogene

Subspecies

Human genetics

10.1007/bf00364801

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Citations (9)

The tumor-initiating and -promoting effects of ionizing radiations in mouse skin.

PubMed (1987)

Akira Ootsuyama Hiroshi Tanooka

The tumor-initiating and -promoting effects of ionizing radiation were tested, using mouse skin as the target organ and 90Sr-90Y beta-rays as the source of radiation. Neither single 2400 rad beta-irradiation followed by repetitive treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) nor single pretreatment with 7,12-dimethylbenz[alpha]anthracene (DMBA) followed by repetitive 470 rad beta irradiation produced tumors above the level of significance within a period of 210 days, while a positive control, DMBA + TPA, yielded a high incidence of papilloma in a shorter period. DMBA exerted an action antagonistic to beta-rays in the induction of malignant tumors. It is concluded that the tumor-enhancing activity of repetitive radiation is qualitatively different from the promoting activity of TPA.

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Development and applications of Bacillus subtilis test systems for mutagens, involving DNA-repair deficiency and suppressible auxotrophic mutations

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (1977)

Hiroshi Tanooka

Methyl methanesulfonate

Auxotrophy

Reversion

Strain (injury)

Ethyl methanesulfonate

Mutation frequency

10.1016/s0027-5107(77)80004-3

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Citations (80)

Concentration effect of bisulfite on the inactivation of transforming activity of DNA

Chemico-Biological Interactions (1972)

Masao Inoue Hikoya Hayatsu Hiroshi Tanooka

Bisulfite

Thymine

10.1016/0009-2797(72)90035-x

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Citations (31)

Application of Bacillus subtilus spores in the detection of gas mutagens: A case of ethylene oxide

Mutation Research/Environmental Mutagenesis and Related Subjects (1979)

Hiroshi Tanooka

Bacillus (shape)

10.1016/0165-1161(79)90113-4

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Citations (12)

Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation.

PubMed (1989)

Akira Ootsuyama Hiroshi Tanooka

Besides skin tumors, osteosarcomas were induced at high frequency in the lumbar vertebrae of ICR mice by repeated local external irradiation of the back with 90Sr-90Y beta-rays when irradiation was repeated three times a week until tumors appeared. The optimum dose range for osteosarcoma induction was 250-350 cGy per exposure at the surface of the back, or 125-175 cGy at the depth of the center of the bone. With the same irradiation schedule, the optimal dose of radiation for induction of osteosarcomas was much lower than that for induction of skin tumors.

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Citations (20)