F. Gonzalez‐Crussi

Northwestern University

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Wei Hsueh

National Cheng Kung University

Pauline M. Chou

Northwestern University

Susan E. Crawford

Alberta Health Services

Cirilo Sotelo‐Avila

Saint Louis University

Xiao‐Di Tan

Northwestern University

Michael S. Caplan

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Anne H. Rowley

Northwestern University

Xiao‐Wu Qu

Northwestern University

Jon K. Miller

Indiana University – Purdue University Indianapolis

Christof Senger

University of British Columbia

Cooperative Institutions

Lurie Children's Hospital

Northwestern University

Northwestern Memorial Hospital

Memorial Medical Center

University of Illinois Chicago

Evanston Hospital

Hektoen Institute

Memorial Hospital

John H. Stroger, Jr. Hospital of Cook County

Johns Hopkins University

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Plasma cell granuloma of the heart

Cancer (1988)

Pauline M. Chou F. Gonzalez‐Crussi Roger M. Cole Vijaya Reddy

A case of plasma cell granuloma arising in the free ventricular wall and involving the coronary arteries of a 10-month-old female infant is presented. Morphologic characteristics were comparable with those of plasma cell granulomas arising elsewhere. The histologic, immunohistochemical, and ultrastructural observations, and in particular the quiescent clinical course of the disease and its control with anti-inflammatory medication, favor a nonneoplastic nature of the lesion. This report documents the presence of an intracardiac plasma cell granuloma for the second time in the medical literature.

Plasma cell granuloma

10.1002/1097-0142(19881001)62:7<1409::aid-cncr2820620728>3.0.co;2-x

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Citations (32)

Complete and incomplete forms of Beckwith-Wiedemann syndrome: Their oncogenic potential

The Journal of Pediatrics (1980)

Cirilo Sotelo‐Avila F. Gonzalez‐Crussi John W. Fowler

Beckwith–Wiedemann syndrome

Variable Expression

10.1016/s0022-3476(80)80322-2

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Citations (297)

Undifferentiated (Embryonal) Liver Sarcoma of Childhood: Evidence of Leiomyoblastic Differentiation

Pediatric Pathology (1983)

F. Gonzalez‐Crussi

AbstractThis report describes the clinical, histopathologic, and ultrastructural features of a tumor of the liver arising in an 11-month-old infant and displaying the morphology of undifferentiated (embryonal) sarcoma. The floss presentation and clinical manifestations showed some overlap with features often considered distinctive of embryonal rhabdomyosarcoma primary of bile ducts. However, electron microscopic study disclosed only fibroblastic and leiomyoblastic differentiation in biopsies of recurrent tumor, close to 2 years after the original diagnosis. Theoretical implications of this finding are discussed.Key Words: liversarcomaleiomyoblastic sarcomaembryonal sarcoma

10.3109/15513818309040665

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Citations (26)

Postinflammatory Elastolysis and Cutis Laxa: Report of a Case with Aortitis

Pediatric Pathology (1983)

Candace C. Christensen F. Gonzalez‐Crussi

A 17-month-old black female manifested an acute febrile dermatosis followed by the development of cutis laxa and aortitis. The neutrophilic, acute inflammatory nature of the disease is emphasized. Pathologically, both the skin and the aorta were affected by a lesional process that shared common morphologic attributes and resulted in extensive elastolysis. However, the disease appears to differ from other entities characterized by generalized degradation of elastic fibers.

Cutis laxa

Aortitis

10.3109/15513818309040658

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Citations (19)

Cellular Hemangiomas (“Hemangioendotheliomas”) in Infants

The American Journal of Surgical Pathology (1991)

F. Gonzalez‐Crussi Miguel Reyes‐Múgica

Cellular hemangiomas of infancy, also known as "infantile hemangioendotheliomas," are benign tumors whose dense cellularity may lead to confusion with soft tissue sarcomas. Ultrastructural and immunohistologic study revealed considerable cellular heterogeneity in these lesions despite the monomorphous appearance revealed by routine histologic preparations. Pericytes and endothelial cells are predominant, but fibroblasts and mast cells are regularly present in these tumors. An interstitially located cell of uncertain identification, expressing factor XIIIa and a macrophage marker, not previously noted, comprises an important segment of the cell population. The cell composition reflects the dynamic potential of these lesions, whose natural tendency is to grow, then to become stable, and finally to involute.

Confusion

10.1097/00000478-199108000-00007

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Intraabdominal Desmoplastic Small-Cell Tumors with Divergent Differentiation

The American Journal of Surgical Pathology (1990)

F. Gonzalez‐Crussi Susan E. Crawford Chen‐Chih J. Sun

We studied three intraabdominal tumors that manifested in childhood and were attached to peritoneum, and in which the histologic pattern suggested metastatic tumor of epithelial nature but gave no evidence of a primary neoplasm in the major abdominal organs. Follow-up observation lasted from 1 to 6 years but never disclosed a primary site. Histologic, immunohistochemical, and electronmicroscopic observations indicated a primitive malignant neoplasm of uncertain histogenesis capable of simultaneously expressing epithelial, mesenchymal, and, less consistently, neural phenotypes. In childhood, the possibility of embryonic neoplasm, such as nephroblastoma occurring in atypical sites, is difficult to exclude. Despite the prevailing uncertainty about histogenesis, combined therapy achieved an apparent cure in one of our cases.

Histogenesis

Neoplasm

10.1097/00000478-199007000-00004

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Citations (120)

Undifferentiated (Embryonal) Sarcoma of the Liver: Ultrastructure, Immunohistochemistry, and DNA Ploidy Analysis of Two Cases

Pediatric Pathology (1990)

Pauline M. Chou Marayart Mangkornkanok F. Gonzalez‐Crussi

We describe the histopathologic, immunohistochemical, electronmicroscopic features, and DNA flow cytometric analysis of 2 cases of undifferentiated (embryonal) sarcoma of the liver. The tumor cells were found to be uniformly nonreactive to antibodies that identify cells belonging to the macrophagic-monocytic system. Focal expression of cytokeratin was an unexpected finding. We conclude that the observations are compatible with origin of this sarcoma from primitive mesenchyme. Uncertainty still exists about histogenesis, but the morphologic features of this neoplasm are quite characteristic. Both tumors demonstrate aneuploid stem lines with high S phase. Whether these findings are prognostically significant remains to be seen.

Histogenesis

Mesenchyme

Neoplasm

10.3109/15513819009067143

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Citations (26)

Necrotizing Enterocolitis of the Newborn: Pathogenetic Concepts in Perspective

Pediatric and Developmental Pathology (1998)

Wei Hsueh Michael S. Caplan Xiao‐Di Tan William MacKendrick F. Gonzalez‐Crussi

Necrotizing Enterocolitis

Enterocolitis

10.1007/s100249900002