Fariel S. Rahman

Western Infirmary

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Matthew R. Walters

University of Glasgow

A J Farida Farzana

Jagannath University

Hajera Mahtab

Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders

Edward Newman

Glasgow Royal Infirmary

Muhammad G. Kibriya

Chicago Department of Public Health

M.S. Hussain

Shaikh Zayed Medical College and Hospital

Md Fakrul Islam

Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders

Kennedy R. Lees

University of Glasgow

Christopher J. Weir

University of Edinburgh

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Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders

University of Glasgow

Western Infirmary

University College London

Queen Elizabeth University Hospital

Cedars-Sinai Medical Center

University of Nottingham

Lighthouse Guild

British Heart Foundation

Charité - Universitätsmedizin Berlin

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Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes

Diabetes/Metabolism Research and Reviews (2005)

Edward Newman Fariel S. Rahman Kennedy R. Lees Christopher J. Weir Matthew R. Walters

Abstract Background Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prognostic significance of elevated serum urate concentration in diabetic subjects following stroke. Methods We studied a cohort of type 2 diabetes patients presenting to our unit with computed tomography‐confirmed acute stroke. Fasting blood samples were drawn within 24 h of admission for urate concentration and standard battery of biochemistry and hematological tests. Information on age, stroke type, prior hypertension, smoking status, resolution time of symptoms and National Institutes of Health Stroke Score was collated. The main outcome event was time to myocardial infarction, recurrent stroke or vascular death, as defined in the CAPRIE trial. Stepwise proportional hazards regression was used to estimate the effect of the above variables on event‐free survival following stroke. Results One hundred and forty patients were studied. Median follow‐up duration was 974 days (IQR 163 to 1830 days). Sixty‐four patients suffered an outcome event. Urate levels of greater than 0.42 mmol/L ( p < 0.001) and an increasing NIHSS score ( p < 0.001) independently predicted increased likelihood of suffering an event. Conclusion Elevated urate concentration is significantly and independently associated with increased risk of future vascular events in diabetic stroke patients. Further studies to elucidate the mechanism of this observation are required. Copyright © 2005 John Wiley & Sons, Ltd.

Stroke

10.1002/dmrr.585

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Citations (70)

Ischaemic heart disease in type-2 diabetic patients in Bangladesh: BIRDEM DCCS

Diabetes Research and Clinical Practice (2000)

Muhammad G. Kibriya M.S. Hussain Md Fakrul Islam A J Farida Farzana Fariel S. Rahman

Ischaemic heart disease

10.1016/s0168-8227(00)81855-0

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