Neil F. Sullivan

University of Pennsylvania

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Alexei A. Lapkin

University of Cambridge

W. Donachie

Moredun Research Institute

Atso Savisaar

Anne E. Willis

University of Cambridge

Mihai Meirovitz

Ben-Gurion University of the Negev

Alberto Lopes

Royal Cornwall Hospital Trust

Graham F. Hatfull

University of Pittsburgh

Jennifer English

University of Cambridge

C N D Smith

Nadia Ouhibi

Ottawa Fertility Centre

Cooperative Institutions

University of Pennsylvania

University of Cambridge

University of Edinburgh

Hospital of the University of Pennsylvania

Children's Hospital of Philadelphia

Penn Center for AIDS Research

Genomics (United Kingdom)

Howard Hughes Medical Institute

University of Pennsylvania Health System

University of Leicester

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Isobologram showing the plot of fractional inhibitory concentration (FIC) of 9-epi-artemisinin (EPI) and artemisitene (ATENE) against FIC of artemisinin (ART) and artesunate (ATSU).

John Suberu Alexander P. Gorka Lauren Jacobs Paul D. Roepe Neil F. Sullivan

Artesunate

Plot (graphics)

10.1371/journal.pone.0080790.g002

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Specificity of the cAMP-induced gene exposure reaction in CHO cells.

Proceedings of the National Academy of Sciences (1988)

Frank Ashall Neil F. Sullivan Theodore T. Puck

Previous studies demonstrated that in the transformed CHO (Chinese hamster ovary) cell a substantial part of the genome behaves as though its genes are sequestered from effective contact with soluble constituents of the intracellular fluid. The reverse transformation reaction, initiated by cAMP derivatives, causes this cell to regain the morphology, growth regulation, surface characteristics, and sensitivity of its DNA to digestion by DNase I that are characteristic of normal fibroblasts. In this paper we show that this action of cAMP is gene specific. In examination of 47 different genetic loci, some, like ribosomal RNA genes, are found to be sensitive to DNase I hydrolysis both in the absence and in the presence of cAMP; some are resistant under both conditions; and some are resistant in the untreated cell but become sensitive after cAMP treatment. Unlike other gene exposure reactions, which are irreversible and connected with differentiation phenomena, that produced by cAMP is readily reversed when the reagent is removed. A sequence of events is observed after cAMP treatment, the first of which is reorganization of the cytoskeleton. Afterwards, metabolic changes occur over periods as long as 72 hr. The cAMP-induced cytoskeleton-mediated gene exposure reaction appears to be an important genetic regulatory mechanism in mammalian cells and to have special implications for cancer.

10.1073/pnas.85.11.3908

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Citations (28)

Volunteers as customers: a service quality perspective.

PubMed (1991)

Keaveney Sm Matthew R. Saltzman Neil F. Sullivan

Not-for-profit service firms depend upon volunteer employees for the success of their programs. This article offers a change in perspective--volunteer as customer instead of employee--to stimulate insights and provide recommendations about attracting and retaining volunteers. The volunteer is viewed as a customer, the service purchased is the volunteer experience, paid for in the currency of donated time and energy, and the not-for-profit service firm is seen as being in the business of designing, managing, communicating, and delivering a quality volunteer experience.

Volunteer

Customer Service

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Bringing your technology to market

Cambridge University Press eBooks (1995)

Neil F. Sullivan

As the births of living creatures at first are ill shapen, so are all innovations, which are the births of time.Francis Bacon Essay: Of innovation 1625

Creatures

10.1017/cbo9780511525377.002

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Overlapping functional units in a cell division gene cluster in Escherichia coli

Journal of Bacteriology (1984)

Neil F. Sullivan W. Donachie

The ftsZ ( sulB ) coding sequence is preceded by two promoters, at least one of which lies within the coding sequence of the neighboring gene, ftsA . This region of the ftsA gene is required for full biological activity of ftsZ .

FtsZ

Coding region

Gene cluster

Sequence (biology)

10.1128/jb.158.3.1198-1201.1984

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Citations (29)

Air Force Avionics Standardization: an Assessment of System/Subsystem Standardization Opportunities.

Supriya Baily Daniel Martinec Atso Savisaar Neil F. Sullivan

Abstract : The following specific contractual tasks were defined for ARINC Research by Aeronautical Systems Division avionics planning directorate ASD/XRE: Task I; Provide Engineering Support in Preparation for Future INS Procurement Activities -- Perform the analyses and trade-off studies to support the Air Force INS Single Agency in the preparation of the RFP and source selection tools for use on the initial standard INS procurement. (This effort was limited to support during the RFP preparation phase only). Task II: Provide Engineering Support in Analyzing New Opportunities for Specification Development -- Investigate and analyze Air Force avionics requirements to determine the patterns, the extent of force applications, and the commonality of force needs. Organize data by class of equipment, quantities, timeframe, application, and other pertinent market survey parameters. Develop criteria for weighing standardization opportunities and ranking opportunities as they are identified. Task III: Provide Engineering Support to Develop, Refine, and Update Avionics Planning Baseline Document -- Perform the Analyses and data collection necessary to develop, refine, and update the Avionics Planning Baseline document.

Baseline (sea)

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Genetic organization of the sep env a gene cluster in escherichia coli

Heredity (1982)

Graham F. Hatfull K J Begg Neil F. Sullivan V Kagan Zur Victoria Derbyshire

Gene cluster

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Development of HPLC analytical protocol for artemisinin quantification in plant materials and extracts SUMMARY

Alexei A. Lapkin Adam J. Walker Neil F. Sullivan Bhupinder P. S. Khambay Benhilda Mlambo

Alexei A. Lapkin,1 Adam Walker,2 Neil Sullivan,3 Bhupinder Khambay,4 Benhilda Mlambo,1 Smain Chemat1 1 Centre for Sustainable Chemical Technologies, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, United Kingdom, A.Lapkin@bath.ac.uk 2 Bioniqs Ltd., Biocentre, York Science Park, Heslington, York, YO10 5DG, United Kingdom 3 SensaPharm Ltd, Unit 124i, BIC, Wearfield, SR5 2TA, Sunderland United Kingdom 4 Kamtech Technologies Ltd, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, United Kingdom

Kingdom

Source

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Financing the business start up

Cambridge University Press eBooks (1995)

Neil F. Sullivan

The licensing option may or may not be suitable for your needs. Perhaps your aspirations and view of the market opportunity now dictate that you should ‘go it alone’ and consider starting your own company. It may be that you are in a position to set up a company and licence your technology through it, rather than your host institution. Whatever the circumstance, you will find that your business wants one thing more than any other – cash! The nature and type of financial arrangements that are available to you will be dictated by the purpose for which you require the money and the degree of risk involved for the investor. Investors are not in general of a charitable nature and will require a return on the investment. The more risk involved, the more justification and analyses you will be expected to provide. There are several mechanisms for financing the venture which are all dependent upon the degree of risk.

Position (finance)

Financial institution

Investment

Institution

10.1017/cbo9780511525377.009

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Citations (2)

Non-tumorigenicity of Bloom's syndrome lymphoblastoid cell lines in immunodeficient mice

European Journal of Cancer and Clinical Oncology (1990)

Neil F. Sullivan

Lymphoblast

Bloom syndrome

10.1016/0277-5379(90)90612-w

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Citations (1)