Sumiya Eto

University of Occupational and Environmental Health Japan

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Acute renal failure prior to the onset of hepatic encephalopathy in fulminant hepatitis

Nephrology (1996)

Kohei Uriu Kazo Kaizu Norio Matuo M Soejima Osamu Hashimoto

Summary: We investigated the clinical characteristics of eight patients with fulminant hepatitis who developed acute renal failure (ARF). They were divided into two groups according to the time point when ARF occurred in the course of the disease: (i) group 1 ( n =4), ARF occurred prior to the onset of hepatic encephalopathy; and (ii) group 2 ( n =4), ARF occurred after the onset of hepatic encephalopathy. All cases in group 1 had an acute type of fulminant hepatitis, whereas a subacute type was present in the patients in group 2. All cases in group 1 and two cases in group 2 were given non‐steroidal antiinflammatory drugs before the onset of ARF. Urinary findings and/or renal biopsy findings suggested that acute tubular necrosis was the cause of ARF in group 1. Three patients in group 1 and none in group 2 recovered from both ARF and fulminant hepatitis. Although it is well‐known that a patient with fulminant hepatic failure complicated by ARF has a poor prognosis, our findings suggest that ARF that occurs prior to the onset of hepatic encephalopathy in acute type of viral fulminant hepatitis is not a determinant of the poor prognosis, and that the prognosis will be improved by intensive care.

Fulminant

Fulminant hepatic failure

Fulminant hepatitis

Hepatic Encephalopathy

10.1111/j.1440-1797.1996.tb00097.x

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Citations (1)

Acute effect of calcium blocker on renal hemodynamics in diabetic spontaneously hypertensive rat

Journal of Diabetes and its Complications (1995)

Kazo Kaizu Qie Yue Ling Kohei Uriu Masanori Ikeda Sumiya Eto

Filtration fraction

Calcium channel blocker

Spontaneously hypertensive rat

Renovascular Hypertension

Glomerular hyperfiltration

Mean arterial pressure

10.1016/1056-8727(95)80027-c

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Citations (2)

Clinical Significance of Serum Ribonuclease (RNase) Assay in Acute Leukemia

Journal of UOEH (1987)

Keiichi MARUOKA Masayoshi Yamanaka S. Oda Shozo CHIBA Sumiya Eto

各種急性白血病における血清RNA分解酵素（RNase）の臨床的意義について検討した. 対象は健常人50例, 未治療急性白血病55例. 未治療CML18例, 治療中CML13例, 反応性白血球増加症20例である. その結果, APL, AML [M2], AMMoL, ELの白血病期において, 酸性RNase対アルカリ性RNaseの活性比（Ac/AI比）は健常人に比し極めて有意に上昇した（P＜0.001）. 特にAPLは全例, AML〔M2〕, AMMoL, ELも大部分で酸性RNaseがアルカリ性RNaseより相対的に上昇を示すため, Ac/AI比は1.0以上を示した. さらに急性白血病では, 寛解期に酸性およびアルカリ性RNase活性は健常人に同様のパターンを呈し, 初診時Ac/Al比が1.0以上を示す急性白血病では再発時には酸性RNaseは上昇し, Ac/Al比は1.0以上に復した. したがって本酵素活性の測定は, 急性白血病において寛解および再発の診断の一助になり得ると考えられた.

Acute myeloblastic leukemia

Acute myelomonocytic leukemia

Leukocytosis

Myelocytic leukemia

Chronic myelomonocytic leukemia

Clinical Significance

Promyelocyte

10.7888/juoeh.9.35

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Citations (1)

DHT formation and degradation in cultured human skin fibroblasts: DHT accumulation in the genital skin

The Journal of Steroid Biochemistry and Molecular Biology (1991)

Isao Morimoto Sumiya Eto Shunji Inoue Motomori Izumi Shigenobu Nagataki

Human skin

Degradation

10.1016/0960-0760(91)90130-w

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Citations (4)

Thyroid cancer with a high 123I-NaI uptake in primary and metastatic foci with euthyroidism

European Journal of Nuclear Medicine (1987)

C Nakayama Hajime Nakata F Zeze Sumiya Eto Y Ichiya

Radioactive iodine

Primary cancer

10.1007/bf00281865

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Citations (2)

Effects of interleukin 1 on growth and adenosine 3',5'-monophosphate generation of the rat thyroid cell line, FRTL-5 cells

European Journal of Endocrinology (1991)

Kazuya Zeki Hiroyuki Azuma H Suzuki Isao Morimoto Sumiya Eto

We investigated the effects of IL-1, IL-2, IL-6, interferon-gamma and tumour necrosis factor-alpha on growth and cAMP generation of FRTL-5 cells. IL-1 produced a significant stimulation of [3H]thymidine incorporation into FRTL-5 cells without TSH, whereas IL-1 caused significant reductions in [3H]thymidine incorporation induced by TSH or forskolin, which is known as an adenylate cyclase activator. Intracellular cAMP generation of FRTL-5 cells was stimulated by IL-1, whereas TSH-stimulated cAMP generation was inhibited by IL-1. These effects of IL-1 was neutralized by addition of anti-IL-1 antibody. The studies suggested that IL-1 blocks the effects of TSH on proliferation and cAMP generation of FRTL-5 cells on a post-receptor site of TSH.

Cyclic adenosine monophosphate

10.1530/acta.0.1240060

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Citations (14)

AUTOANTIBODY TO BOVINE TSH IN HASHIMOTO'S THYROIDITIS

The Lancet (1984)

Sumiya Eto Takashi Fujihira Sumiko Ohnami H Suzuki

Hashimoto Disease

Anti-thyroid autoantibodies

10.1016/s0140-6736(84)92896-4

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Citations (13)

Constitutive Chemokine Production Results in Activation of Leukocyte Function-Associated Antigen-1 on Adult T-Cell Leukemia Cells

Blood (1998)

Yoshiya Tanaka Shinichiro Mine Carl G. Figdor Atsushi Wake Hideyasu Hirano

Wortmannin

10.1182/blood.v91.10.3909

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Citations (75)

A case of subacute necrotizing lymphadenitis associated with aseptic meningitis.

Nihon Naika Gakkai Zasshi (1986)

Yoshihiro Yamasaki Shyozo Chiba M Misago Tohru Tsuda S. Oda

症例は23才の男性.右頚部に自発痛を有するリンパ節腫が出現し,昭和59年2月23日当科に入院した.入院時,両側頚部,鼡径部に自発痛を伴う母指-小指頭大のリンパ節を数個触知,頚部リンパ節の生検所見にて部分的な壊死性組織破壊像が認められ,亜急性壊死性リンパ節炎と診断した.入院第8病日より激しい頭痛,悪心を訴え,髄液中の単核球優位な細胞増加,およびその他の髄液検査所見より無菌性髄膜炎と診断した.亜急性壊死性リンパ節炎に無菌性髄膜炎を合併した症例の報告は極めて少なく,原因不明と言われる亜急性壊死性リンパ節炎の病因解明の手がかりになる事も期待され,両者の関連性について若干の文献的検索を加えて考察した.

Aseptic meningitis

Aseptic processing

10.2169/naika.75.687

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Citations (5)

Hypercalcemia in malignancy.

Nihon Naika Gakkai Zasshi (1991)

Sumiya Eto

Malignant tumors are often complicated by hypercalcemia (malignancy associated hypercalcemia: MAHC) which causes various clinical symptoms. Hypercalcemia may occasionally lead to death. Unfortunately, many physicians caring for patients with malignant diseases are not aware of this danger. Hypercalcemia is seen in about 15% of patients with solid tumors. This condition is more frequent in some malignant proliferative hematological diseases. In patients with multiple myeloma, the incidence of hypercalcemia is about 20%. The rate of complication by hypercalcemia is as high as 80% in patients with adult T cell leukemia. The symptoms of hypercalcemia include anorexia, easy fatigability, nausea, and vomiting. These symptoms are often mistaken for adverse effects of anticancer drugs or as signs of aggravation of malignant disease. If abnormal thirst and polydipsia are noted in patients with malignant disease, a diagnosis of MAHC should always be considered because these two symptoms are highly characteristic of hypercalcemia. Caution should be exercised when CNS symptoms such as unstable emotions or somnolence are noted. These symptoms in patients with MAHC may lead to death, if untreated. The corrected serum calcium level should always be monitored in patients with malignant disease, so that a possible diagnosis of MAHC may not be overlooked when these symptoms appear. MAHC is caused by the bone resorption stimulating factor (BRSF), which is produced and secreted by the tumor cells. BRSF may act systemically to cause increased bone resorption, resulting in hypercalcemia. MAHC occurring in this manner is called the 'humoral hypercalcemia of malignancy (HHM)'. BRSF produced by multiple myeloma or bone metastasis enhances bone resorption through local osteolysis.(ABSTRACT TRUNCATED AT 250 WORDS)

10.2169/naika.80.1534

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Citations (7)