J.M. Gimferrer

10587 Background: miRNAs play an important role in carcinogenesis through the regulation of different genes. miR-SNPs are a novel class of SNPs that can affect miRNA biogenesis and miRNA target sites and can alter miRNA expression and functions. We have evaluated 11 miR-SNPs in a series of 175 resected NSCLC p and correlated our findings with TTR. Methods: In 175 NSCLC p who underwent complete surgical resection between March 1996 and December 2009, we examined 11 miR-SNPs: 5 in miRNA genes (miR-194-2 rs11231898; miR-196a-2 rs11614913; miR-149 rs2292832; miR-423 rs6505162; miR-146a rs2910164); 3 in miRNA binding sites (KRT81 rs3660; FAM179B rs1053667; AFF1 rs17703261) and 3 in miRNA-processing machinery (XPO5 rs11077; RAN rs14035; TRBP rs784567). DNA was obtained from paraffin-embedded or fresh frozen tumor tissue and allelic discrimination assay with ABI Prism 7500 was performed. Results: p characteristics: mean age, 65 (35-85); 88% male; 149 (85.1%) PS 1; 98 (56%) stage I, 40 (22.9%) stage II, 37 (21.1%) stage III; 80 (45.7%) adenocarcinoma, 84 (48%) squamous cell carcinoma, 11 (6.3%) other histologies; 28 (16%) received adjuvant treatment, 9 (5.1%) received neoadjuvant treatment; mean follow-up 35 months (m); 75 (42.9%) p relapsed. Only stage (P=0.008) and KRT81 genotype were associated with TTR. Median TTR for 45 p (25.9%) with the CC genotype was 20.3 m vs 86.8 m for p with the CG or GG genotype (P=0.003). Among 98 p with stage I disease, median TTR was 23.9 m for 25 p (25.5%) with the CC genotype vs 100.2 m for p with the CG or GG genotype (P=0.002). In the multivariate analysis, KRT81 CC genotype (OR, 2.14; 95%CI, 1.29-3.55; P=0.003), stage I disease (OR, 0.36; 95%CI, 0.18-0.73; P=0.005) and male sex (OR, 5.25; 95%CI, 1.56-17.73; P=0.008) emerged as independent variables for TTR. Conclusions: KRT81 rs3660 SNP may be a novel marker for TTR in resected NSCLC, mainly in stage I, where it can help to detect high-risk patients who may be candidates for adjuvant treatment.

SNP

10.1200/jco.2011.29.15_suppl.10587

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Citations (0)

Subglottic stenosis in an HIV positive patient: an exceptional form of clinical presentation in Kaposi's sarcoma

European Journal of Cardio-Thoracic Surgery (1997)

J. Belda E. Canalı́s J.M. Gimferrer Antoni Xaubet X. Baldó

The case of a 29-year-old HIV positive male patient suffering from a Kaposi's sarcoma exclusively located in the proximal third of the trachea and subglottic region is presented.The patient was found to have included an obstruction of the upper airway.A characteristic endoscopic appearance led to the final diagnosis.A combined treatment with Nd-YAG laser endoscopic resection and laringotracheal irradiation was performed.Pathological examination confirmed Kaposi's sarcoma.

Airway obstruction

Kaposi's sarcoma

Presentation (obstetrics)

Subglottic stenosis

10.1016/s1010-7940(96)01010-x

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Citations (3)

Bronchial Carcinoid Tumor: a Retrospective Analysis of 62 Surgically Treated Cases

Archivos de Bronconeumología (2004)

M. Iglesias J. Belda X. Baldó J.M. Gimferrer Marc Catalán‐García

Carcinoid tumors

10.1016/s1579-2129(06)70087-8