Nick Chow

Duke-NUS Medical School

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Shun Qiang Lo

National University of Singapore

Ryuichi Nakajima

The University of Tokyo

James J. Mancuso

The University of Texas MD Anderson Cancer Center

M Matsuzaki

The University of Tokyo

Carolin Hoffmann

Maastricht University

Jonathan T. Ting

University of Washington

Haruo Kasai

The University of Tokyo

Wen Lei

ARC Centre of Excellence for Transformative Meta-Optical Systems

Gregory Tan

Duke-NUS Medical School

Brent Asrican

University of North Carolina at Chapel Hill

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Duke-NUS Medical School

Agency for Science, Technology and Research

The University of Tokyo

Duke Medical Center

Duke University

Marine Biological Laboratory

Duke University Hospital

Nanyang Technological University

Institute of Molecular and Cell Biology

National University of Singapore

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Next-generation transgenic mice for optogenetic analysis of neural circuits

Frontiers in Neural Circuits (2013)

Brent Asrican George J. Augustine Ken Berglund Susu Chen Nick Chow

Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.

Channelrhodopsin

Photostimulation

Halorhodopsin

Biological neural network

10.3389/fncir.2013.00160

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