Fatma M Fouda

Ain Shams University

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Bosy A. Abd El-Motelp

Ain Shams University

Mohamed A. El-Emam

Benha University

Soheir Mahmoud

Theodor Bilharz Research Institute

E G Kamel

Ain Shams University

SAMIHA MOHAMED ABD ELDAYEM

Ain Shams University

Fatma E.A. Bayaumy

Ain Shams University

Elham H.A. Ali

Ain Shams University

HADER FAWZY DARWISH

Ain Shams University

Cooperative Institutions

Ain Shams University

Theodor Bilharz Research Institute

Benha University

Delta University for Science and Technology

Al-Azhar University

University of Tripoli

Mansoura University

Danish Centre for Marine Research

Al Yarmouk University College

Al-Azhar University

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Attenuation of Schistosoma mansoni cercarial infectivity to albino mice by methanol extract of some plant species

Pesticide Biochemistry and Physiology (2010)

E G Kamel Mohamed A. El-Emam Soheir Mahmoud Fatma M Fouda Fatma E.A. Bayaumy

Infectivity

Schistosoma

Freshwater mollusc

10.1016/j.pestbp.2010.07.007

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Citations (14)

Anti-tumor activity of tetrodotoxin extracted from the Masked Puffer fish Arothron diadematus

Egyptian Journal of Biology (2005)

Fatma M Fouda

Anti-tumor activity of tetrodotoxins extracted from the skin of the Masked Puffer fish (Arothron diadematus) from the Red Sea was evaluated using the Ehrlich ascite carcinoma tumor model in mice. Activity was assessed using a variety of cellular and liver biochemical parameters. Experimental mice were divided into 4 equal groups and injected intra-peritoneally with: saline (control); a sub-lethal dose of the toxin (1\10 LD50); 1 ml of a solution containing 2 million ECA cancer cells; and both (1 ml of a solution containing 2 million ECA cancer cells and a sub-lethal dose of toxin). Subsets of mice from each group were dissected after 3, 6, 9, and 12 days. Statistical analyses demonstrated the following: - the anti-tumor activity of the toxin increased lifespan by 46%, in addition to decreasing the number of tumor cells. - There was also an obvious cytotoxic effect of tetrodotoxins on cells, leading to apoptosis and a decrease in the volume of the peritoneal fluid. - The negative effects of tumor cells on the biochemical processes of liver was illustrated by an increased release of MDA & GGT enzymes and fat oxidation, and a decreased release of both enzymes and anti-oxidation agents. These negative effects were relieved for 6 days after injection by toxin.

Liver Cancer

Intraperitoneal injection

10.4314/ejb.v7i1.56480

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The antitumor effects of tetrodotoxin and/or doxorubicin on Ehrlich ascites carcinoma-bearing female mice

Toxicology and Industrial Health (2012)

SAMIHA MOHAMED ABD ELDAYEM Fatma M Fouda Elham H.A. Ali Bosy A. Abd El-Motelp

The study aimed to investigate the antitumor effect of tetrodotoxin (TTX) and/or doxorubicin (DOX) on Ehrlich ascites carcinoma (EAC)-bearing mice through the investigated biochemical parameters. TTX and/or DOX with or without N-acetylcystiene were administrated after 10 days into EAC-female mice for a period of 2 weeks in six equal doses. Treatment with TTX or DOX caused a significant decrease in the mean tumor weight and an increase in the cumulative mean survival time when compared with EAC group. All the treatments reduced the elevated liver tumor markers and increased liver antioxidant enzymes under investigation in comparison with EAC. Hepatic cells, suffered severely from degeneration and karriolysis in EAC group, revealed some improvement as appearance of healthy hepatocytes by TTX treatment. The present results suggested that TTX had a more powerful inhibitor effect on EAC growth than DOX and TTX plus DOX treatments reflected by antitumor biochemical and histological studies.

Ehrlich ascites carcinoma

Tetrodotoxin

10.1177/0748233711434955

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Citations (35)

Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban

Parasitology International (2011)

E G Kamel Mohamed A. El-Emam Soheir Mahmoud Fatma M Fouda Fatma E.A. Bayaumy

Sesbania sesban

10.1016/j.parint.2011.06.016

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Citations (42)

POTENTIAL ROLE OF ANNONA SQUAMOSA LINN EXTRACT AND N-ACETYL CYSTEINE IN MANAGEMENT OF RIFAMPICIN-INDUCED HEPATOXICITY IN RATS

International Journal of Pharmacy and Pharmaceutical Sciences (2020)

Bosy A. Abd El-Motelp HADER FAWZY DARWISH SAMIHA MOHAMED ABD ELDAYEM Fatma M Fouda

Objective: Rifampicin (RIF) could be a recognized therapeutic and preventive agent against tuberculosis. Still, high rates of many side effects and symptoms related to hepatotoxicity have identified during treatment. So, the current study was aimed to evaluate the antioxidant and hepatoprotective activity of methanolic extract of Annona Squamosa Linn (MEAS) and N-Acetyl Cysteine (NAC) against RIF induced hepatic injury in male rats. Methods: The hepatoprotective effects of MEAS (500 mg/kg b.wt.) and NAC (100 mg/kg b.wt.) or co-treatment were assessed in a model of hepatotoxicity by RIF (300 mg/kg b. wt.) in male rats daily for 21 d. Moreover, bilirubin, total protein, albumin, ALT, AST, ALP, GGT, MDA, and GSH were estimated. In addition, the levels of IL-6, IL-10, 8(OH)dG, and Bcl2 were evaluated. Results: The oral administration of MEAS and NAC or their combination resulted in significant reductions in the levels of bilirubin, albumin, hepato-specific markers namely ALT, AST, ALP, GGT, and MDA as compared to the RIF group. Furthermore, MEAS and NAC or the combination of MEAS and NAC treatment significantly up-regulated the levels of total protein, glutathione reductase with concomitant decrease in inflammatory marker level IL-6 and apoptotic marker level 8(OH)dG as well as increment the level of anti-inflammatory marker IL-10 and anti-apoptotic marker Bcl2 as compared to the RIF group. Histological examination of the liver tissue indicated that co-treatment with MEAS and NAC completely abolished the inflammation and degeneration in hepatocytes and restore the liver tissue to its normal structure. Conclusion: The present findings demonstrated that a co-treatment of MEAS and NAC seems to be more productive and curative than alone MEAS or NAC treatment and strongly compensated the liver damage induced by RIF.

Annona squamosa

Glutathione reductase

10.22159/ijpps.2020v12i8.38424

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