C. M. Sultanpur

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

C. S. Mahajanshetti

Jawaharlal Nehru Medical College

A. D. Tarnalli

Andanappa K. Gadad

University of the West Indies

Imtiyaz Ahmed M. Khazi

Karnatak University

Srinath Satyanarayana

International Union Against Tuberculosis and Lung Disease

Navineel Reddy

University of the South Pacific

V. Saritha

S. Rubbani

New York University

N. Srinivasa Reddy

St. Peter's Institute of Higher Education and Research

Suresh Kumar

Pakistan Institute of Medical Sciences

Cooperative Institutions

Karnatak University

Jawaharlal Nehru Medical College

Indian Institute of Chemical Technology

University of the South Pacific

Advanced Materials and Processes Research Institute

Institute of Minerals and Materials Technology

Council of Scientific and Industrial Research

University of Chicago Medical Center

University of Illinois Chicago

University of Illinois Urbana-Champaign

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

ChemInform Abstract: Synthesis, Anticonvulsant and Analgesic Activities of Some 6‐ Substituted Imidazo(2,1‐b)‐1,3,4‐thiadiazole‐2‐sulfonamides and Their 5‐Bromo Derivatives.

ChemInform (1997)

Imtiyaz Ahmed M. Khazi C. S. Mahajanshetti Andanappa K. Gadad A. D. Tarnalli C. M. Sultanpur

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199711111

Cite

Citations (6)

Drug-Drug Interaction between Pravastatin and Gemfibrozil (Antihyperlipidemic) with Gliclazide (Antidiabetic) in Rats

Journal of Young Pharmacists (2010)

C. M. Sultanpur Navineel Reddy Suresh Kumar Srinath Satyanarayana K. E. Mothi Kumar

Diabetes mellitus is a condition of increased blood glucose level in the body. Antihyperlipidemic drugs like statins and fibrates are widely used for prophylactic treatment in dyslipideamia and atherosclerosis. Diabetic dislipidemia exists with increased triglycerides, low HDL and high LDL levels. Hence, with oral hypoglycemic drugs, the addition of a lipid-lowering drug is necessary for controlling dislipidemia. In such a situation, there may be chances of drug–drug interactions between antidiabetic and antihyperlipidemic drugs. The present study is planned to evaluate the safety of gliclazide (antidiabetic) in the presence of pravastatin and gemfibrozil (antihyperlpidemic) in rats. Studies in normal and alloxan-induced diabetic rats were conducted with oral doses of gliclazide and their combination with pravastatin and gemfibrozil, with an adequate washout period in between the treatments. Blood samples were collected in rats by retroorbital puncture at 0, 1, 2, 3, 4, 6, 8, 10 and 12 h. All the blood samples were analyzed for glucose by GOD –POD. Gliclazide (½ TD) produced hypoglycemic activity in normal and diabetic rats, with peak activity at 2 and 8 h. Pravastatin (TD) + gemfibrozil (TD) combination treatment increased the hypoglycemic effect of gliclazide in normal rats or diabetic rats when administered together. The interaction observed due to inhibition of both the enzymes (CYP 450 2C9 and CYP 450 3A4) responsible for the metabolism of gliclazide showed increased half-life, which was seen in the present study. Because concomitant administration of gliclazide with provastatin and gemfibrozil in diabetes is associated with atherosclerosis, it should be contraindicated or used with caution.

Gliclazide

Gemfibrozil

Drug-drug interaction

Repaglinide

10.4103/0975-1483.63157

Cite

Citations (10)

Evaluation of nootropic activity of Curcuma longa leaves in diazepam and scopolamine-induced amnesic mice and rats

International Journal of Basic & Clinical Pharmacology (2015)

N. Srinivasa Reddy C. M. Sultanpur V. Saritha

Background: The present study was undertaken to assess the nootropic activity of hydroalcoholic extract of Curcuma longa leaves (HAECL) in diazepam-induced amnesia in mice using Morris water maze method and scopolamine-induced amnesia in rats by using elevated plus maze behavioral paradigm and its effect on acetylcholinesterase (AChE) and reduced glutathione (GSH) level were carried out.Methods: Amnesia was induced by administration of diazepam (1 mg/kg i.p.) and scopolamine (0.4 mg/kg i.p.) and treatment groups received HAECL (200 and 400 mg/kg p.o) for 14 and 10 days in scopolamine and diazepam-induced amnesia model, respectively. The extent of improvement in memory was measured by behavioral paradigm. Finally, animals were sacrificed, and the whole brain was isolated for estimation of concentration of AChE and reduced GSH levels.Results: The oral treatment with HAECL with a dose 400 mg/kg has shown an enhancement in the memory function compared to 200 mg/kg.Conclusion: This could be by inhibiting the levels of cholinesterase concentration of enzyme and thereby increasing the concentration of acetylcholine level in brain and improving cognition-memory performance.

Scopolamine

Nootropic

10.18203/2319-2003.ijbcp20150378

Cite

Citations (4)

Synthesis, anticonvulsant and analgesic activities of some 6-substituted imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamides and their 5-bromo derivatives.

PubMed (1996)

Imtiyaz Ahmed M. Khazi C. S. Mahajanshetti Andanappa K. Gadad A. D. Tarnalli C. M. Sultanpur

A series of 6-substituted imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamides (V) were prepared by condensation of 2-amino-1,3,4-thiadiazole-5-sulfonamide (II) with an appropriate 2-bromo-ketone (III). Bromination of V in glacial acetic acid gave the corresponding 5-bromo derivatives (VI). Five selected compounds (15-18 and 28) were evaluated for their anticonvulsant and analgesic activities. Compounds 15-17 showed maximum protection (83%) against pentylene tetrazole induced convulsions and maximum electroshock induced seizures while the standard phenobarbital sodium and phenytoin sodium showed 100% protection, respectively. Compounds 15, 16 and 18 showed superior analgesic activity to acetylsalicylic acid in rat caudal immersion test.

Tetrazole

Phenobarbital

Source

Cite

Citations (36)

Drug-drug interaction between fluvastatin and fenofibrate (antihyperlipidemic) with gliclazide (antidiabetic) in rats.

IEEE Transactions on Biomedical Engineering (2008)

C. M. Sultanpur Srinath Satyanarayana G. P. Kalaskar S. Rubbani

Fenofibrate

Gliclazide

Fluvastatin

Source

Cite

Citations (0)