The metabolism of the polycydlic hydrocarbon dibenzo [a,e]-fluoranthene (DBF) has been investigated. Two new primary metabolites have been identified by proton n.m.r. as the trans diaxial dihydrodiols of the bay and of the pseudo bay regions of DBF. In addition, twelve new melabolites arising from secondary and tertiary metabolic transformations have been identified. The stereochemistry of eleven of these products has been established by proton n.m.r. spectroscopy. In contrast with other alternant carcinogenic polycycic hydrocarbons, a vicinal diol epoxidation at the bay region of the trans diequatorial dihydrodiols is a minor reaction relative to attack at distant sites, which leads principally to phenolic derivatives of the dihydrodiols and, with a lower yield, to a bis-dihydrodiol (3,4,12,13-tetrabydro-3,4,12,13-tetra-hydroxy-DBF). This offers a possibility of bifunctional metabolic activation in the carcinogenicity of DBF. A catechol of the benzanthracenic moiety of DBF has also been identified, dibenzo[a,e]fluoranthene 3,4-catechol. In summary, all three external rings of DBF can be attacked enzymatically, but apparently ring E does not undergo epoxidalion while more usual trans diaxial and diequatorial dihydro-diols, as well as tetraols of rings A and D, were detected.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlavoquinone-metal complexes. II. Paramagnetic interactionsJ. Lauterwein, P. Hemmerich, and J. M. LhosteCite this: Inorg. Chem. 1975, 14, 9, 2161–2168Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://pubs.acs.org/doi/10.1021/ic50151a027https://doi.org/10.1021/ic50151a027research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In July 1970, a legal blood alcohol content was established in France. On this occasion an information campaign was undertaken in order to familiarize road users with the provisions of the new law and to encourage them to adopt behaviour conducive to safety. The following points have been studied: the state of public opinion regarding the problem of drinking and driving; the attitudes regarding the new law; research into psychological factors and the determination of the contents of the messages to be used in the course of the campaign. The methods employed were qualitative: in-depth interviews and group discussions, and quantitative: opinion surveys, scales of attitudes, segmentation and typology. Results demonstrate that important differences exist between knowledge, opinions and behaviour. On the other hand, it was possible to demonstrate the difficulties arising from the use of mass media. Models were proposed for information activities which are diversified in relation to different systems of attitudes which characterise individual target groups. /TRRL/
