Yílmaz Nişancí

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457 Validity of the right ventricular isovolumic myocardial acceleration to assess the severity of rheumatic mitral stenosis

European Journal of Echocardiography (2006)

Yelda Tayyareci Zehra Buğra Berrin Umman İbrahim Altun Sebahattin Yurdakul

p<0.005).And the decrease in tenting area with dobutamine had a good correlation with increase in Ssr in the inferior segment (r=0.62, p<0.01), but neither increase in Ssr in the anterior, anteroseptal, posteroseptal, posterior nor lateral segment.Furthermore, the decrease in MR volume fraction was correlated with increase in Ssr in the inferior segment (r=0.63, p<0.01). Conclusions:The results of this study suggest that inferior myocardial systolic function may affect the configuration of mitral apparatus and may be one of the determinants of functional MR severity.

10.1016/s1525-2167(06)60247-3

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Citations (0)

Percutaneous coronary intervention increases microvascular resistance in patients with non-ST-elevation acute coronary syndrome

EuroIntervention (2013)

Cansu Akdeniz Sabahattin Umman Yílmaz Nişancí Berrin Umman Zehra Buğra

In the acute coronary syndrome setting, the interaction between epicardial coronary artery stenosis and microcirculation subtended by the culprit vessel is poorly understood. The purpose of the present study was to assess the immediate impact of percutaneous coronary intervention (PCI) on microvascular resistance (MR) in patients with non-ST-elevation myocardial infarction (NSTEMI).Thirty-eight patients undergoing PCI for NSTEMI were recruited consecutively. Culprit lesions were stented over a Doppler and pressure-sensor-equipped guidewire. In the presence of epicardial stenosis, MR was calculated by taking collateral flow, as measured by the coronary wedge pressure, into consideration. After removal of epicardial stenosis, MR was calculated simply as distal coronary pressure divided by average peak velocity. When collateral flow was incorporated into the calculation, MR increased significantly from 1.70 ± 0.76 to 2.05 ± 0.72 (p=0.001) after PCI in the whole population. Periprocedural changes (Δ) in absolute values of MR and troponin T correlated significantly (r=0.629, p=0.0001). In patients who developed periprocedural myocardial infarction, MR increased significantly after PCI (1.48 ± 0.73 versus 2.28 ± 0.71, p<0.001). Nevertheless, removal of the epicardial lesion did not change MR in patients without periprocedural MI (1.91±0.73 versus 1.81±0.67, p=0.1).When collateral flow is accounted for, removal of epicardial stenosis increases MR in patients with NSTEMI undergoing PCI.

Culprit

TIMI

Fractional Flow Reserve

10.4244/eijv9i2a38

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Citations (7)

The Role of Exercise on Platelet Aggregation in Patients with Stable Coronary Artery Disease: Exercise Induces Aspirin Resistant Platelet Activation

Journal of Thrombosis and Thrombolysis (2005)

Burak Pamukçu Hüseyin Oflaz Ali Deniz Sabahattin Umman Nevres Koylan

Hematology

10.1007/s11239-005-2318-1

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Citations (43)

Emery‐Dreifuss muscular dystrophy with unusual features

Muscle & Nerve (1993)

Feza Deymeer Ali Emre Öge Çiçek Bayındır Cıhangır Kaymaz Yílmaz Nişancí

Abstract Two families with Emery‐Dreifuss muscular dystrophy (EMD) are described. Several unusual features for EMD are emphasized. One of the patients had severe neuromuscular disability with inability to walk during early childhood. This patient also had mild bifacial paresis. His brothers had the typical slow progression of EMD. In some of the patients, muscle weakness distribution was more widespread than has usually been reported, with prominent involvement of finger extensors. It is suggested that there is a wide phenotypic spectrum in EMD. In both families, the disease segregated with markers spanning the EMD locus in Xq28. © 1993 John Wiley & Sons, Inc.

10.1002/mus.880161214

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Citations (9)

The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events

Journal of Thrombosis and Thrombolysis (2006)

Burak Pamukçu Hüseyin Oflaz Aytaç Öncül Berrin Umman Fehmi Mercanoğlu

Hematology

10.1007/s11239-006-8952-4

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Citations (73)

The trivest in overreaching syndrome: Cardiac fatigue, muscular weakness, and vascular dysfunction

International Journal of Cardiology (2007)

Erdem Kaşıkçıoğlu Hüseyin Oflaz Aytaç Öncül Abidin Kayserilioğlu Sabahattin Umman

Brachial artery

10.1016/j.ijcard.2007.04.089

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Citations (8)

Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR)

Blood Coagulation & Fibrinolysis (2007)

Burak Pamukçu Hüseyin Oflaz İmran Önür Aytaç Öncül Mustafa Özcan

Aspirin resistance may increase the risk of major adverse cardiac events (MACE) more than threefold in patients with stable coronary artery disease (CAD). This study aimed to determine the prevalence of aspirin resistance in patients with stable CAD, the role of aspirin resistance on outcome in the follow-up, and the effect of clopidogrel therapy in MACE prevention in aspirin-resistant individuals. We detected the prevalence of aspirin resistance in 234 patients with stable CAD. Platelet function was determined by PFA-100 with collagen and/or epinephrine and collagen and/or ADP cartridges. The mean follow-up time was 20.6 +/- 6.9 months. The primary endpoints of the study were occurrence of myocardial infarction, unstable angina, stroke and cardiac death. Of patients, 22.2% (n = 52) were aspirin resistant by PFA-100. During follow-up, MACE occurred in eight patients (15.4%) with aspirin resistance and in 20 patients (11.0%) with aspirin-sensitive platelet aggregation (P = 0.269). MACE increased in aspirin-resistant patients after termination of clopidogrel therapy. Eleven patients experienced MACE after cessation of clopidogrel therapy (P < 0.001). The MACE risk in patients with stable CAD having detected aspirin resistance was similar compared with patients having aspirin-sensitive platelet aggregation by PFA-100. The MACE prevalence increased during follow-up, however, just after cessation of clopidogrel therapy.

Mace

Unstable angina

10.1097/mbc.0b013e328040c115

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Citations (47)

Aspirin-resistant platelet aggregation in a cohort of patients with coronary heart disease

Blood Coagulation & Fibrinolysis (2007)

Burak Pamukçu Hüseyin Oflaz İmran Önür Aytaç Öncül Berrin Umman

Aspirin resistance could be defined as thrombotic and embolic cardiovascular events despite regular aspirin therapy. The study aimed to determine the profile and prevalence of aspirin resistance in coronary artery disease patients. We evaluated the prevalence of aspirin resistance in a cohort of 505 patients with the diagnosis of coronary artery disease taking 80–300 mg regular aspirin daily. Platelet functions were analyzed by the Platelet Function Analyzer (PFA)-100 with collagen and epinephrine cartridges and collagen and ADP cartridges. A closure time of 186 s or less with the collagen and epinephrine cartridge was defined as aspirin resistance. Of the patients, 118 (23.4%) were aspirin resistant by the PFA-100. Aspirin-resistant patients were more likely to be older than aspirin-sensitive patients (P = 0.024). No statistically significant differences between the aspirin-resistant and aspirin-sensitive individuals were present in gender, major risk factors of coronary artery disease, number and localization of involved coronary vessels, serum lipid levels, and blood counts. According to the high prevalence of coronary heart disease, many people are affected by aspirin resistance, which may play a role in adverse cardiovascular events. Monitoring of platelet function in patients with coronary heart disease may support the optimization of antiplatelet therapy with additional and/or alternative agents.

10.1097/mbc.0b013e32814db7e7

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Citations (21)

Acute anterior myocardial infarction in a young man with essential thrombocythemia: A case report

International Journal of Angiology (2004)

Ercüment Yılmaz Ahmet Kaya Bilge Berrin Umman Fehmi Mercanoğlu Aytaç Öncül

Essential thrombocythemia is a rare cause of ischemic cardiovascular events. A 23-year-old young man was admitted with chest pain to the coronary care unit. Electrocardiogram revealed acute anterior myocardial infarction (AMI). He had a platelet count 748,000/mm3 and detailed hematologic investigation led to the diagnosis of essential thrombocythemia. Coronary angiography revealed two vessel disease, with 95% stenosis in the middle of left anterior descending artery (LAD), thrombotic occlusion of distal LAD and recanalized thrombus in the right coronary artery (RCA). Apical akinesia and anterolateral hypokinesia was present by left ventriculography. In the same session, glycoprotein IIb/IIIa receptor antagonist drug (tirofiban) therapy was started and after 4 × 16 mm NIR primo stent was implanted in the middle of the LAD. With aspirin 300 mg/day and ticlopidine 500 mg/day therapy, platelet count was found to be around 530,000–550,000/mm3. Clinical follow-up of the patient showed no chest pain. Six months after angioplasty, stent in the LAD and distal of LAD was found to be open with control coronary angiography. Recanalized thrombus in RCA showed no difference. Medical follow up is decided. We decided to report this case since essential thrombocythemia is a rare disease that may result in serious life-threatening cardiovascular complication.

Angiology

10.1007/s00547-003-0948-8

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Citations (1)

[Intracoronary stem cell implantation during post myocardial infarction period--a case report].

Yílmaz Nişancí Ayhan Olcay Berrin Umman Murat Sezer Sevgi Kalayoğlu Beşışık

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Citations (2)