The authors report the case of a 41-year-old woman who developed an acute graft-versus-host disease following bone marrow transplantation for post-polycythemic myeloid metaplasia; liver, cutaneous and intestinal lesions were present, associated with a severe protein-losing enteropathy. Symptoms, diagnostic procedures and therapy of intestinal graft-versus-host disease are reviewed. The intestinal clearance of alpha-1 antitrypsin was particularly useful to assess the response to medial treatment, which induced a complete remission.

Protein losing enteropathy

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Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines

Blood (1993)

P. Martiat Philippe Lewalle A. S. Taj Marianne Philippe Yvan Larondelle

K562 cells

ABL

HeLa

10.1182/blood.v81.2.502.502

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Citations (56)

Cigarette smoking and chronic polyclonal B-cell lymphocytosis.

PubMed (1993)

André Delannoy D Djian G Wallef V Deneys Pierre Fally

A syndrome associating a polyclonal increase of B-cells with binucleate lymphocytes in peripheral blood and a polyclonal increase of serum IgM, accompanied or not by splenomegaly and lymphadenopathy, has been reported in young to middle-aged women who are cigarette smokers. The majority of patients were HLA-DR7 positive and their clinical course remained stable over periods of years. We report four cases of this syndrome. In all patients, DNA analysis provided additional evidence that the lymphocytosis was polyclonal, while in one patient who met all other symptomatic criteria the total lymphocyte count was normal. This would suggest that unless careful attention is paid to the morphology of the lymphocytes, the syndrome may go undiagnosed.

Lymphocytosis

Polyclonal antibodies

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Citations (19)

2-Chlorodeoxyadenosine in refractory non-Hodgkin's lymphoma: A phase II study on 50 patients.

Blood (1995)

André Bosly Augustin Ferrant Anne Sonet André Delannoy Guy Cornu

Refractory (planetary science)

Cladribine

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Citations (5)

[Exudative enteropathy caused by an acute graft-vs-host reaction. Apropos of a case report].

PubMed (1990)

J M Ghilain P. Martiat René Fiasse A Ferrant J. L. Michaux

The authors report the case of a 41-year-old woman who developed an acute graft-versus-host disease following bone marrow transplantation for post-polycythemic myeloid metaplasia; liver, cutaneous and intestinal lesions were present, associated, with a severe protein-losing enteropathy. Symptoms, diagnostic procedures and therapy of intestinal graft-versus-host disease are reviewed. The intestinal clearance of alpha-1 antitrypsin was particularly useful to assess the response to medial treatment, which induced a complete remission.

Protein losing enteropathy

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Progression-free survival (PFS) of patients with chronic lymphoproliferative disorders after therapy with 2-chlorodeoxyadenosine (CdA)

British Journal of Haematology (1996)

Marie Maerevoet Augustin Ferrant Lucienne Michaux Anne Sonet André Delannoy

Lymphoproliferative Disorders

Progression-free survival

Hematology

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