Eufrasio Loza

Inserm

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ÉL

Évelyne Lhoste

Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés

Jacques Marescaux

Institut de Recherche contre les Cancers de l’Appareil Digestif

C Stock-Damgé

Institut National de Recherche en Santé Publique

Marc Aprahamian

Institut de Recherche contre les Cancers de l’Appareil Digestif

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Institut de Recherche contre les Cancers de l’Appareil Digestif

Université de Strasbourg

Inserm

Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés

Centre National de la Recherche Scientifique

Université Gustave Eiffel

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Ministère de l’Environnement, de la Lutte contre les changements climatiques, de la Faune et des Parcs

Institut National de la Recherche Scientifique

Ministère des Forêts, de la Faune et des Parcs

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Small bowel bypass prevents the trophic action of cholecystokinin on the rat pancreas

International Journal of Pancreatology (1987)

C Stock-Damgé Marc Aprahamian Évelyne Lhoste Jacques Marescaux Eufrasio Loza

The effect of a chronic administration of cholecystokinin (CCK) on the rat pancreas has been studied in rats subjected to a 90% jejunoileal bypass or an intestinal transection (controls). Jejunoileal bypass, when compared to transection, did not modify the size of the pancreas but decreased its enzyme content, especially for amylase, and reduced the number of zymogen granules. These structural and biochemical changes were maintained when bypassed animals were treated three times daily and for six days with cholecystokinin (20 Ivy Dog Units (IDU)/kg). In contrast, CCK treatment in transected animals induced growth of the pancreas due to cellular hypertrophy and hyperplasia; pancreatic enzyme content, especially for chymotrypsin, and the population of zymogen granules in acinar cells were also enhanced. It is concluded that jejunoileal bypass prevents the trophic action of chronic CCK on the pancreas.

Zymogen

10.1007/bf02788403

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Citations (4)