Ying Yao

First Affiliated Hospital of Soochow University

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Song Jin

Soochow University

Lingzhi Yan

Soochow University

Chengcheng Fu

Soochow University

Jingjing Shang

Hebei Medical University

Depei Wu

First Affiliated Hospital of Soochow University

Weiqin Yao

Soochow University

Jin Zhou

Soochow University

Xiaolan Shi

Soochow University

Zhiyuan Xu

Zhejiang Cancer Hospital

Guanghua Chen

Soochow University

Cooperative Institutions

Soochow University

First Affiliated Hospital of Soochow University

Peking University

Nanjing Medical University

Kunming Medical University

Shanghai Jiao Tong University

Huazhong University of Science and Technology

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Yan'an Hospital Affiliated To Kunming Medical University

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Application of the Conditioning Regimen with Busulfan and Cyclophosphamide in Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Blood (2017)

Yang Xu Ying Yao Weiqin Yao Song Jin Lingzhi Yan

Melphalan

Regimen

Autologous stem-cell transplantation

10.1182/blood.v130.suppl_1.5517.5517

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Citations (3)

Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies

Gynecological Endocrinology (2019)

Jie Zhou Ying Yao Xiaoping Huang Daozhen Chen Ting Zhang

The purpose of this meta-analysis was to investigate the relationship between bile salt export pump (BSEP) polymorphisms and intrahepatic cholestasis of pregnancy (ICP) susceptibility. Retrieved studies from Pubmed, EMBASE, Web of Science, Cochrane Library and CBM databases about BSEP polymorphisms and ICP susceptibility were included. Odds ratio (OR) and 95% confidence interval (CI) and publication bias were calculated. Ten related case-control studies on BSEP polymorphisms and ICP susceptibility were included. The pooled results showed a significant association between BSEP rs2287622 polymorphism and ICP risk in Asian population (OR >1, p < .01 for A vs. a and AA vs. Aa/aa) and general population (OR >1, p < .05 for A vs. a, Aa vs. aa, AA/Aa vs. aa), and a borderline statistical significance was found between BSEP rs473351 polymorphism and ICP susceptibility (OR = 1.66, p < .05), and no statistical significance was found in D482G or rs853782 polymorphisms and ICP risk (all p > .05). Additionally, no publication bias was found in these studies (all p > .05). Our current meta-analysis indicated that BSEP rs2287622 polymorphism could increase the susceptibility of ICP in Asians and in general populations, while rs473351, D482G, and rs853782 polymorphisms were not obviously associated with ICP risk, but it needs further larger study with ethnicity and various etiologies.

Cholestasis of pregnancy

Subgroup analysis

10.1080/09513590.2018.1512570

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Citations (4)

Targeting 1q21 Amplification with APG2575 and Lenalidomide to Sensitize BCL-2 Inhibition with the Decrease of MCL-1 Protein in High Risk MM Models

Blood (2020)

Yan Xie Chengcheng Fu Lingzhi Yan Song Jin Jingjing Shang

Ixazomib

Viability assay

10.1182/blood-2020-139195

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Citations (1)

The Prognostic Significance of Minimal Residual Disease Detection after Induction and ASCT to the Patients with Multiple Myeloma

Blood (2018)

Weiqin Yao Ming-qing Zhu Feirong Yao Lingzhi Yan Song Jin

Minimal Residual Disease

Autologous stem-cell transplantation

Univariate analysis

10.1182/blood-2018-99-118257

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Citations (1)

Sequential CD19 and BCMA‐specific CAR T‐cell treatment elicits sustained remission of relapsed and/or refractory myeloma

Cancer Medicine (2020)

Lingzhi Yan Su Qu Jingjing Shang Xiaolan Shi Liqing Kang

Abstract The low rate of durable response against relapsed and/or refractory multiple myeloma (RRMM) in recent studies indicates that chimeric antigen receptor T‐cell (CART) treatment is yet to be optimized. This study aims to investigate the safety and efficacy of sequential infusion of CD19‐CART and B‐cell maturation antigen (BCMA)‐CARTs for RRMM with a similar 3 + 3 dose escalation combined with a toxicity sentinel design. We enrolled 10 patients, among whom 7 received autologous infusion and 3 received allogeneic infusion. The median follow‐up time was 20 months. The most common grade 3/4 treatment‐emergent toxicities were hematological toxicities. Cytokine‐release syndrome (CRS) adverse reactions were grade 1/2 in 9 out of 10 subjects. No dose‐limited toxicity (DLT) was observed for BCMA‐CAR‐positive T cells ≤5 × 10 7 /kg), while two patients with dose‐levels of 5–6.5 × 10 7 /kg experienced DLTs. The overall response rate was 90% (five partial responses and four stringent complete responses). Three out of four patients with stringent complete responses to autologous CART had progression‐free survival for over 2 years. The three patients with allogeneic CART experienced disease progression within 2 months. These results evidence the sequential infusion's preliminarily tolerability and efficacy in RRMM, and present a simple and safe design applicable for the establishment of multiple CART therapy.

Cytokine Release Syndrome

Tolerability

Cart

Refractory (planetary science)

10.1002/cam4.3624

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Citations (43)

Value of fetal cardiac axis measured in the fetal echocardiography of the second trimester

Zhonghua chaosheng yingxiangxue zazhi (2012)

Yun Zhang Yingliu Yan Wei Zhao Xiaowei Huang Ying Yao

Objective To establish the reference ranges for fetal cardiac axis in the mid-second trimester and to evaluate the use of fetal cardiac axis in prenatal diagnosis.Methods 6744 unselected singleton pregnancies were enrolled from September 2008 to October 2010.Routine screening scan of second trimester and fetal echocardiography were performed at 18- 23+6 weeks gestation.Fetal cardiac axis was measured on the four-chamber view of the heart.Results The 6744 fetuses had a mean cardiac axis of (37.03 ± 6.10)°,ranging from 9.80° to 102.41°. Using above or below 95％ range of population (26.63° -49.40°) as a cut-off,there were significant difference of cardiac axis between normal group [(36.96 ± 5.91)°,P ＜0.01] and the group with heart defects [(43.12 ± 15.67)°,P ＜0.01],the group with intrathoricic anomalies or abdominal wall defect [(51.74 ± 15.97)°].Conclusions The reference ranges of fetal cardiac axis for local population in mid-second trimester may helpful for detecting congenital defects.Presence of an abnormal cardiac axis in the fetuses is associated with a substantial risk of congenital heart disease and/or other extra cardiac defects. Key words: Ultrasonography,prenatal; Cardiac axis; Heart defects,congenital

Fetal echocardiography

Fetal heart

10.3760/cma.j.issn.1004-4477.2012.01.014

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[Florid cystic endosalpingiosis of uterine subserosa: report of a case].

PubMed (2024)

Shaoli Zhou Lin Lu Ying Yao Lei Shi Lin Dai

子宫显著的囊性输卵管内膜异位症罕见，临床和影像学诊断困难。本文报告1例子宫浆膜下显著的囊性输卵管内膜异位症。患者女，43岁，常规体检经阴道超声检查发现卵巢囊肿，腹腔镜术中考虑为子宫平滑肌瘤伴有囊性退变，术后病理学检查诊断为子宫浆膜下显著的囊性输卵管内膜异位症。.

10.3760/cma.j.cn112151-20230926-00219

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Comparison of the anterior pelvis and levator ani muscle on MRI in women with and without anterior pelvic organ prolapse

International Urogynecology Journal (2023)

Junfang Yang Kun Zhang Jinsong Han Yi‐Ting Wang Ying Yao

Levator ani

Female pelvis

10.1007/s00192-023-05464-x

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Citations (1)

Correlation of serum cystatin C with left ventricular hypertrophy in maintenance hemodialysis patients

BMJ (2009)

Xiaoyun Si Xiaohong Bi Ying Yao Ping Le Xiaoyan Wu

The clinical data and routine biochemical parameters of 64 maintenance hemodialysis (MHD)patients and 20 controls were analyzed in the study.Serum cystatin C levels were detected by latex particle enhalice inununo-turbidimetry:and the cardial structure and function were assessed by echocardiography.As MHD time extended,the levels of semm cystatin C increased gradually,accompanied with high incidence of left ventricular hypertrophy(LVH).The LVH-positive patients had higher systolic blood pressure and left veHtricular mass index,and had higher serum cystatin C than tllose in LVH-negative patients.The serum cystatin C levels were positively correlated with left yentricular mass index(r=0.633,P<0.01)and systolic blood pressure(r:0.397,P<0.01).The results suggest that serum cystatin levels may be an influencing factor for long-term cardiacvascular complication in MHD patients. Key words: Hemodialysis; Cystatin C; Hypertrophy,left ventricular

10.3760/cma.j.issn.1671-7368.2009.07.019

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Citations (0)

Tandom Autologous Transplantation and Combined Infusion of CD19 and Bcma-Specific Chimeric Antigen Receptor T Cells for High Risk MM: Initial Safety and Efficacy Report from a Clinical Pilot Study

Blood (2018)

Xiaolan Shi Lingzhi Yan Jingjing Shang Su Qu Liqing Kang

Cell therapy

Minimal Residual Disease

10.1182/blood-2018-99-117964

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Citations (59)