In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among the current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy in combating inflammation. However, the indeterminate structures and limited enzyme-like activity exhibited by most developed nanozymes impede their clinical translation and therapeutic effectiveness. In this paper, we developed a nanozyme derived from a well-defined metal-organic cage (MOC). The oxidized MOC (MOC-O), containing pyridine nitrogen oxide moieties, exhibited effective cascade superoxide dismutase (SOD) and catalase (CAT)-like activities for scavenging reactive oxygen species (ROS). This ROS scavenging ability was confirmed through flow cytometry analysis using DCFH-DA in a hypoxia/reoxygenation (H/R) model, where MOC-O significantly alleviated oxidative stress. Furthermore, the administration of MOC-O resulted in preserved renal function during renal ischemia-reperfusion (I/R) injury due to downregulated oxidative stress levels and reduced cell apoptosis.
The conversion of plastic waste to high value-added aromatics such as benzene, toluene, ethylbenzene, xylene (BTEX) through catalytic pyrolysis offers huge untapped opportunities for resource recovery and plastic pollution control. Economical equipment configuration, operation and maintenance, high safety factor, high efficiency, stability, low-cost catalyst synthesis design, high yield, high selectivity of products are the key to the practical application of catalytic pyrolysis. In present study, low-cost and large-grain ZSM-5 was synthesized by one-pot in situ hydrothermal method using kieselguhr as silicon-aluminum source. The acid acidity of kieselguhr based ZSM-5 was modulated via the coordination of primary transition metals and alkaline earth metals with the acid sites of silica-aluminum frameworks. The catalyst was filled in a fixed-bed reactor for catalytic pyrolysis of mask waste at atmospheric pressure to produce aromatics. The yield of C5-C26 pyrolysis oil is 43%, showing high BTEX selectivity of 76.3%, while para-xylene dominants in xylene. That shows great practical application potential in aromatics industry and saves substantial energy consumption in chemical separation. The excellent shape-selectivity of kieselguhr based ZSM-5 is benefit for its extended straight channels and maximum sinusoidal channels,which facilitates the diffusion and transport of intermediates/products of appropriate size within the structure, resulting in preponderantly distributed products. This study proposes an efficient and feasible plastic closed-loop strategy for green upgrading of medical waste to high value-added chemicals.
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