ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of the Nitrogen—Carbon—Nitrogen System in N1-Heterocyclic Sulfanilamides1Robert G. Shepherd, A. Calvin Bratton, and Kenneth C. BlanchardCite this: J. Am. Chem. Soc. 1942, 64, 11, 2532–2537Publication Date (Print):November 1, 1942Publication History Published online1 May 2002Published inissue 1 November 1942https://pubs.acs.org/doi/10.1021/ja01263a002https://doi.org/10.1021/ja01263a002research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Four and one-half inches of 3/8″ Visking sausage casing is moistened at one end and tied to a frame. Five cc. of blood is run into the open end from a syringe or pipette. The open end is tied and the string attached to the other side of the frame, stretching the casing as much as it will bear, and it is dried 40 min. at 100° in an oven. It is then placed in a screw-feed stoking device with detachable water-cooled platinum tip and burned with 120 cc. of oxygen per minute in a platinum combustion tube heated by gas. The screw feed is advanced 1″ in 20 min. by motor. The combustion products are led through a pyrex absorber containing 3 sintered glass discs and 25 mg. of sodium azide in 10 cc. of water. At the end of the combustion the stoking tube is removed from the platinum tip, which is allowed gradually to heat, the gas flame is turned off, and the absorber contents and ash are transferred to a 100 cc. pyrex still, using 4 cc. N/10 NaOH and 10 cc. H2O to rinse out. Most of the water is evaporated off while passing a small current of air to prevent bumping, and 3 cc. 6 N H2SO4 is introduced into the still. The iodine is distilled over into a 10 cc. receiver containing 1 cc. of bromine water without immersing the tip. The trap is flamed to prevent iodine remaining in drops of water in it. When SO3 fumes appear in the still, the flame is reduced to 5 mm. and continued for 4 more minutes. After allowing the air to continue until all condensate has run down into the receiver, the tip is washed, volume made to 9 cc, and an air current blown through it in a steam bath for 1/2 hour to remove the bromine. Twelve and one-half mg. KI is introduced, the volume is made to 10 cc, and it is titrated with 0.001 N sodium thiosulfate in a Lochte-Hoover burette with divisions of 0.001 cc. (while rapidly stirred) using an electrometric method for indicating the end-point. Burette readings are plotted against voltage, the curve showing a sharp angle at the end-point. Blanks are run on all the reagents and subtracted from the results. Human blood gave 0.1-0.7γ in 5 cc. On adding iodine, the following was recovered (Table I):
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic Nitrogen Bases from Pyrolysis of Cottonseed Meal1Ivy Parker, C. L. Gutzeit, A. C. Bratton, and J. R. BaileyCite this: J. Am. Chem. Soc. 1936, 58, 7, 1097–1104Publication Date (Print):July 1, 1936Publication History Published online1 May 2002Published inissue 1 July 1936https://pubs.acs.org/doi/10.1021/ja01298a010https://doi.org/10.1021/ja01298a010research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A qualitative comparison of the in vitro and in vivo activity on β-hemo1ytic streptococcus of 126 compounds consisting of sulfanilamide derivatives, sulfonamides, suifones, sulfoxides, sulfides and certain miscellaneous compounds has been made. It has been shown that no compound is active in vivo unless it is active in vitro or can be decomposed in the animal body to a compound which would be active in vitro , and that compounds can be active in vitro but inactive in vivo.
1. A method incorporating a simple rotary injection pump is described for continuous intravenous administration of drugs to ducks infected with P. lophurae. 2. On the basis of dosage, quinine was more effective at the level of minimum therapeutic response when given intravenously in single daily doses than when given by continuous infusion; at a high level of response, the converse was true 3. At the level of minimum response, cinchonine was equally effective when given in single daily intravenous doses or continuously. 4. Tartar emetic, sodium antimony thioglycollate, and mapharsen were effective in doses at or near the toxic level. 5. Penicillin, streptomycin, and quitenine were inactive in the doses employed. 6. Summation of therapeutic response was shown by the following two combinations: quinine-cinchonine, and quinacrine-6-chloro-9-(2-diethylaminoethylamino)-2-methoxyacridine. No summation of response was exhibited by the following combinations: quinine-quinacrine, quinine-pamaquine, and quinacrine-pamaquine. These results suggest that quinine, quinacrine, and pamaquine each possess a different principal mechanism of drug action against P. lophurae in the duck.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Rapid Method for Protein DialysisF. W. Bernhart, L. Earle Arnow, and A. C. BrattonCite this: Ind. Eng. Chem. Anal. Ed. 1937, 9, 8, 387–388Publication Date (Print):August 1, 1937Publication History Published online1 May 2002Published inissue 1 August 1937https://pubs.acs.org/doi/10.1021/ac50112a013https://doi.org/10.1021/ac50112a013research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
'%3e%3cpath fill='%23012169' d='M0 0v30h60V0z'/%3e%3cpath stroke='%23fff' stroke-width='6' d='m0 0 60 30m0-30L0 30'/%3e%3cpath stroke='%23C8102E' stroke-width='4' d='m0 0 60 30m0-30L0 30' clip-path='url(%23b)'/%3e%3cpath stroke='%23fff' stroke-width='10' d='M30 0v30M0 15h60'/%3e%3cpath stroke='%23C8102E' stroke-width='6' d='M30 0v30M0 15h60'/%3e%3c/g%3e%3c/svg%3e)