The serum uric acid concentration in normal healthy subjects has been studied in relation to sex, height, weight, lean body mass measured from total body potassium and predicted from the Hume-Weyers formula (1971), total body potassium, plasma potassium and urea, and packed cell volume. The strongest correlation was found with sex, but height, weight, total body potassium, lean body mass (measured and predicted) also correlated significantly with serum uric acid concentration. However, when the sex variable was removed, the other factors lost their significant correlation. Finally, total red blood cell and plasma volumes were predicted (Hume and Goldberg, 1964) and from these an estimate of total plasma uric acid, total plasma potassium, and total red blood cell potassium obtained. Measured total body potassium was found to correlate well with total plasma potassium and total red blood cell potassium independent of sex. Total plasma uric acid correlated well with measured total body potassium when both sexes were considered and when separated into male and female groups the males retained a significant correlation as did the female group.
Both manganese (Mn) exposure and iron deficiency (ID) have been linked to alterations in behavior, such as anxiety and locomotion, due to neurochemical disturbances. To date, no study has looked at the longitudinal behavioral alterations in the unaltered home cage of animals exposed to Mn or ID. Therefore, we sought to examine the effects of ID and Mn exposure over a three‐week period to determine time and dose‐dependent behavioral changes. Twenty one day old male rats were randomly placed into one of four dietary treatment groups: control, iron‐deficient, control with Mn exposure (via the drinking water), and iron‐deficient with Mn exposure. Rats were monitored for 24 hours during weeks four, five, and six of the dietary protocol using the Clever Systems Home Cage Scan video surveillance system. Several novel findings emerged from this study. For example, although ID was associated with a decrease in total distance traveled over time as previously reported, Mn exposure was related to an increase in total distance traveled over time which is contrary to prior reports of reduced locomotor activity in Mn exposed animals. While studies have examined effects of either Mn exposure or ID over short observational periods, this is the first to examine these effects on exploratory, locomotor, and autonomic behaviors longitudinally over a 24‐hour period in the home cage environment.
The oral contraceptive Minilyn (50 mcg ethinyl estradiol and 2.5 mg lynestrenol) significantly reduced plasma testosterone in 9 hirsute women from mean 2.09 nmol/1 (range 1.27-2.95) to mean 1.27 (range .64-1.80) during intake. 1 patient had . 97 nmol testosteone/1 while she was taking Minovlar (50 mcg ethinyl estradiol and 1 mg norethisterone acetate), and then .45 nmol/1 during treatment with Minilyn. The progestagen used probably has a bearing on clinical effects of an oral contraceptive in virilization.
It is concluded that osteoporosis is a generalized phenomenon in rheumatoid arthritis, relating more to the duration of the arthritis than to the presence of treatment with corticosteroid therapy.
A patient is described who developed multiple areas of inflammatory pyoderma on the face, leading to extensive ulceration. Repeated investigations failed to demonstrate any specific bacteria or fungus responsible and trials of treatment with various antibiotics proved unsuccessful. Histology revealed a granulomatous abscess‐like lesion, and the condition resembled what has been described as malignant pyoderma. The patient was successfully treated with oral dapsone and intralesional steroids.
Journal Article An assessment of (i) cyproterone acetate and (2) ethinyloestradiol and lynoestrenol (Minilyn) in the treatment of ‘idiopathic’ hirsutism Get access J.A.R. Anderson, J.A.R. Anderson University of Dundee, Dundee Search for other works by this author on: Oxford Academic Google Scholar Margaret C.K. Browning Margaret C.K. Browning University of Dundee, Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 20–21, https://doi.org/10.1111/j.1365-2133.1977.tb14306.x Published: 01 December 1977
The administration of cyproterone acetate can be effective in the treatment of ‘idiopathic’ hirsutism. In 5 similarly affected patients treated with ethinyloestradiol and lynoestrenol (Minilyn) the rate of hair growth was reduced in only two, even though the serum total testosterone was reduced in each instance.
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