In March 2020, the World Health Organization designated the disease Coronavirus Disease 2019 , which caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), as a pandemic.Prognosis of the disease proceed generally mildly in pediatric cases.Rarely, children have been affected severely and prognosis can be different from adult patients.Since May 2020, reports from different countries documented a presentation in children and this condition has been termed as multisystem inflammatory syndrome in children.This report, we presented an 8-year-old patient who was admitted to the hospital with complaints of fever and abdominal pain, was operated by a pediatric surgeon with the diagnosis of acute appendicitis, was followed up with the multisystemic inflammatory syndrome clinic in pediatric intensive care unit, and received intravenous immunoglobulin, steroid, plasmapheresis treatments and inotropic support.This report, we wanted to emphasize that in the COVID-19 pandemic, there may be hospital applications with different clinical presentations in the childhood age group, and the use of intravenous immunoglobulin and plasmapheresis treatment combination can be a life-saving option, especially in multisystem inflammatory syndrome in children cases requiring intensive care.