J. R. Egerton

University of Sydney

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William C. Campbell

Purdue University West Lafayette

C.H. Eary

Merck & Co., Inc., Rahway, NJ, USA (United States)

Om P. Dhungyel

University of Sydney

D. Suhayda

Merck & Co., Inc., Rahway, NJ, USA (United States)

S.C. Ghimire

Health Canada

I. M. Parsonson

Zoos Victoria

A. C. Cuckler

New York State Department of State

John S. Mattick

UNSW Sydney

Belinda Anderson

Pace University

Herman W. Raadsma

University of Sydney

Cooperative Institutions

Merck & Co., Inc., Rahway, NJ, USA (United States)

University of Sydney

Commonwealth Scientific and Industrial Research Organisation

Département Santé Animale

Merck Institute for Science Education

Australian Centre for Disease Preparedness

UNSW Sydney

Health Sciences and Nutrition

University of Melbourne

New South Wales Department of Primary Industries

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Anthelmintic Activity of Paraherquamide in Sheep

Journal of Parasitology (1990)

W.L. Shoop J. R. Egerton C.H. Eary D. Suhayda

Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei, was tested against the common gastrointestinal nematode species of sheep at 0.25, 0.5, 1.0, and 2.0 mg/kg, per os. It was highly efficacious (greater than or equal to 98% reduction) as a single oral treatment dosages greater than or equal to 0.5 mg/kg against adult Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis and Cooperia curticei, and the L4 stage of Cooperia spp. Noteworthy is the fact the isolate of H. contortus used was ivermectin-resistant and the isolate of T. colubriformis used was ivermectin- and benzimidazole-resistant. This suggests a different mode of action for paraherquamide relative to ivermectin and the benzimidazoles. The adult stage of Oesophagostomum columbianum was the dosage-limiting parasite with 79% efficacy recorded at the highest treatment level (2.0 mg/kg). Extrapolation from the O. columbianum response curve suggests a dosage in excess of 4.0 mg/kg would be required to attain 95% efficacy.

Ostertagia ostertagi

Dose

Trichostrongylus

Eggs per gram

10.2307/3282664

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Citations (66)

Statistical analysis applied to numbers of worms recovered by post mortem examination.

Journal of Parasitology (1953)

J. R. Egerton

Statistical Analysis

Source

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Citations (0)

Diseases of the Feet

J. R. Egerton

10.1002/9780470753316.ch39

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Citations (13)

DISEASES TRANSMITTED FROM ANIMALS TO MAN

Australian Veterinary Journal (1976)

J. R. Egerton

10.1111/j.1751-0813.1976.tb13865.x

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Citations (102)

Effect of alum-precipitated or oil-adjuvant Bacteroidcs nodosus vaccines on the resistance of sheep to experimental foot rot

Research in Veterinary Science (1981)

J. R. Egerton C.M. Thorley

Alum

Inactivated vaccine

Foot rot

10.1016/s0034-5288(18)32602-x

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Citations (21)

PATHOLOGY OF DOMESTIC ANIMALS

Australian Veterinary Journal (1972)

C. R. Huxtable J. R. Egerton

10.1111/j.1751-0813.1972.tb02309.x

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Citations (150)

Vertical transmission of reticuloendotheliosis virus in chickens

Avian Pathology (1987)

M.X.J. Motha J. R. Egerton

In this study, the vertical transmission of reticuloendotheliosis virus (REV) in chickens was examined using 6-month-old birds with viraemia which had persisted since birth. Eggs collected from such hens were incubated within 24 hours of lay and it was found that 18 of 35 of the progeny were infected with REV. Seventeen of the 18 died before they were 28 days of age, due to a nervous syndrome. Some of the eggs laid by viraemic hens were stored at room temperature between 1 and 10 days and were then incubated. Hatched progeny from the eggs stored up to 4 days were infected. Hens free of REV, but inseminated by roosters with persistent viraemia seroconverted to REV. A small proportion of chickens which hatched (2/24) were infected with REV. Embryos were a better source for virus isolation than albumen samples.

Reticuloendotheliosis virus

10.1080/03079458708436359

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Citations (17)

Relationship between the likelihood of footrot elimination from a flock and the virulence of the strain of Dichelobacter nodosus present

Australian Veterinary Journal (2018)

MB Allworth J. R. Egerton

Objective To assess ability to eliminate different strains of footrot in sheep using inspection and culling of affected sheep. Methods A flock of 1417 Polwarth sheep that had deliberately been infected with seven different strains of Dichelobacter nodosu s and undergone different control measures prior to eradication, including zinc sulfate footbathing and vaccination, were subjected to visual foot inspection on a number of occasions. Sheep identified as infected or having any foot abnormalities were removed from the flock at each inspection. The experiment had three replicates and a small number of untreated control animals. Sheep were examined following the inspections to assess the effectiveness of elimination and additional measures were implemented in two of the three replicates in an attempt to eliminate all strains of D. nodosus. Results Three strains of D. nodosus were apparently successfully eliminated from all replicates (strains A, E and H). Strains B and C were detected in one replicate each, despite additional inspections. The three stains that were eliminated were the more virulent strains and the two strains that remained were the least virulent. No assessment could be made on a further two strains. Conclusions The application of a rigorous inspection and culling program resulted in the elimination of the more virulent D. nodosus strains, but did not result in the elimination of all D. nodosus strains on all occasions.

Flock

Strain (injury)

10.1111/avj.12750

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Citations (8)

PROPHYLACTIC AND THERAPEUTIC VACCINATION AGAINST OVINE FOOT-ROT

Australian Veterinary Journal (1970)

J. R. Egerton D.H. Burrell

Animal health

10.1111/j.1751-0813.1970.tb06636.x

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Citations (67)