Gang‐Joon Heo

Chungbuk National University

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Sabrina Hossain

Adena Regional Medical Center

B.C.J. De Silva

Southern Cross University

P.S. Dahanayake

Chungbuk National University

S.H.M.P. Wimalasena

Gyeongsang National University

H.N.K.S. Pathirana

Jeonbuk National University

M.V.K.S. Wickramanayake

Chungbuk National University

Gee‐Wook Shin

Jeonbuk National University

Mahanama De Zoysa

Chungnam National University

Prasanga Madhushani Kumarage

Chungbuk National University

Sana Majeed

Chungbuk National University

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Chungbuk National University

Chungnam National University

Gyeongsang National University

Jeonbuk National University

Jeju National University

Veterinary Medical Center

Yonsei University

Korea Institute of Ocean Science and Technology

Government of the Republic of Korea

Seoul National University

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멜라민과 cyanuric acid의 농도별 혼합투여에 따른 메기(Silurus asotus) 신장에서의 조직병리학적 소견

韓國家畜衛生學會誌 = Korean journal of veterinary service (2011)

한세희 Gang‐Joon Heo

【The recent outbreak of renal failure in infants in China and in animals in USA and Europe has been determined to be caused by melamine adulterated in the food. In the course of the investigation, cyanuric acid was identified in addition to melamine in the offending food. Fish feeds were also recently found to be contaminated with melamine. The purpose of this study was to characterize the histopathological effect and toxicity potential of different concentrations of melamine and cyanuric acid in the kidney of Japanese catfish (Silurus asotus). The fish were administered melamine and cyanuric acid in combination at the concentrations of 12.5, 25, 50, 100 and 200 mg/kg/day for 3 days by single oral administration dissolved in carboxymethyl cellulose. The results showed that renal crystals were observed in renal tubules and collecting ducts at the concentration over 25 mg/kg dose group and the number of crystals in kidney were in proportion to the concentrations of melamine and cyanuric acid.】

Cyanuric acid

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Pseudomonas aeruginosa from pet Chinese stripe-necked turtles (Ocadia sinensis) demonstrating antimicrobial and heavy metal resistance

Veterinary Integrative Sciences (2022)

M.V.K.S. Wickramanayake Liyana Arachchilage Dinithi Sandunika De Silva Gang‐Joon Heo

Leading nosocomial pathogen Pseudomonas aeruginosa has increasingly been reported to be an opportunistic pathogen. In this study, a total of twenty P. aeruginosa isolates were isolated from 40 pet Chinese stripe-necked turtles and examined for their antimicrobial and heavy metal resistance properties. All isolates were multidrug resistance by scoring multiple antimicrobial resistance indices ≥0.2. In the disc distribution test, 100% resistance to ampicillin and oxacillin were detected. In addition to that, 14 (70%) isolate demonstrated amoxicillin resistance. Imipenem, fosfomycin, gentamycin, tobramycin and piperacillin resistance were detected in 40%, 15%, 20%, 10% and 5% of the isolates, respectively. The ESBLs gene that predominated in this study was blaSHV (55%), followed by blaTEM (50%), blaCTX (10%) and blaOXA (5%). The most frequent aminoglycoside resistance gene in this study was aac(6´)-Ib (40%). Class1 integron integrase gene intI1 and class 1 integron gene cassette gene aadA1 were detected in 45% and 35% of the isolates, respectively. All P. aeruginosa isolates demonstrated Cu and Cd resistance. CzcA and CopA genes were detected in 65% and 30% of the isolates, respectively. These findings reveal the presence of pet turtle-born P. aeruginosa can be a potential risk to public health and cannot be excluded as a non-nosocomial source of infections.

Gene cassette

Fosfomycin

10.12982/vis.2022.059

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Prevalence of virulence and antimicrobial resistance genes in Aeromonas species isolated from marketed cockles ( Tegillarca granosa ) in Korea

Letters in Applied Microbiology (2020)

P.S. Dahanayake Sabrina Hossain M.V.K.S. Wickramanayake Gang‐Joon Heo

This study aimed to examine incidence, virulence and antimicrobial properties in Aeromonas spp. isolated from cockles (Tegillarca granosa) in Korea. Firstly, genomic DNA was extracted from 32 Aeromonas spp. isolates, and PCR screening for virulence, antimicrobial resistance genes was carried out. The disk diffusion assay was used to examine antimicrobial susceptibility. Aeromonas spp. isolates comprised, A. hydrophila (n = 8), A. veronii (n = 15), A. media (n = 2), A. salmonicida (n = 2), A. allosaccharophila (n = 1), A. bestiarum (n = 1), A. culicicola (n = 1), A. enteropelogenes (n = 1) and A. rivipollensis (n = 1). High prevalence of virulence‐related genes reported as; act (69%), alt (47%), ast (41%), aerA (56%), lip (50%), ahyB (47%), ser (28%), fla (66%), gcat (44%), ascV (50%) and hlyA (72%). All isolates were multidrug resistant, while highest resistance level observed for ampicillin (100%), followed by imipenem (81%), rifampicin (78%), cephalothin (72%), piperacillin (47%) and Colistin sulfate (31%). The presence of blaSHV, blaCTX, tetE, aac(6')‐Ib, strA‐strB, qnrS, qnrB and IntI1 genes were reported in varying combinations. Nevertheless, blaTEM, blaIMP, tetA, tetB, qnrA, qnrB and aphAI‐IAB genes and the class1 integron were not detected. The high occurrence of virulence and antimicrobial resistance genes in cockles reveals that it can be a potential health risk source for consumers.

Aeromonas veronii

Colistin

10.1111/lam.13261

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Citations (19)

Aeromonas spp. Isolated from Pacific Abalone (Haliotis discus hannai) Marketed in Korea: Antimicrobial and Heavy-Metal Resistance Properties

Current Microbiology (2020)

M.V.K.S. Wickramanayake P.S. Dahanayake Sabrina Hossain Mahanama De Zoysa Gang‐Joon Heo

Aeromonas veronii

Aeromonas salmonicida

10.1007/s00284-020-01982-9

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Occurrence of Flavobacterium branchiophila associated with bacterial gill disease at a trout hatchery.

Fish Pathology (1990)

Gang‐Joon Heo Kazuhiko Kasai Hisatsugu Wakabayashi

A field survey was carried out for four years in order to investigate the occurrence of Flavobacterium branchiophila infection at the Okutama Trout Hatchery affiliated to Tokyo Metropolitan Fisheries Experimental Station. The gills and the skin of fish collected from rearing ponds were examined by indirect fluorescent antibody technique (IFAT), plating method and light microscopy. The water from the fish ponds was also examined.IFAT were more sentitive and specific in detection of F.branchiophila than plating method or light microscopy. F. branchiophila was always associated with bacterial gill disease outbreaks that exhibited typical clinical signs. In other words it was detected from both fish and water during the period of the outbreaks only. Outbreaks of F. branchiophila gill disease occurred intermittently in the same fish population. Therefore the recovered fish appeared not to obtain immunity against the pathogen.

Hatchery

10.3147/jsfp.25.99

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Phylogenetic characteristics, virulence properties and antibiogram profile of motile Aeromonas spp. isolated from ornamental guppy (Poecilia reticulata)

Archives of Microbiology (2019)

Sabrina Hossain B.C.J. De Silva P.S. Dahanayake Mahanama De Zoysa Gang‐Joon Heo

Aeromonas veronii

Oxolinic acid

Guppy

10.1007/s00203-019-01762-5

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Citations (18)

Antibiotic and heavy metal resistance genes inAeromonasspp. isolated from marketed Manila Clam (Ruditapes philippinarum) in Korea

Journal of Applied Microbiology (2019)

P.S. Dahanayake Sabrina Hossain M.V.K.S. Wickramanayake Gang‐Joon Heo

AimsManila clam (Ruditapes philippinarum) is one of the most popular seafood in Korea, owing to their unique taste and nutritional value. This study aimed to disclose the antibiotic and heavy metal resistance characteristics of Aeromonas spp. isolated from marketed Manila clam in Korea.

Ruditapes

10.1111/jam.14355

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Citations (48)

Communications: Efficacy of Norfloxacin for the Control ofEdwardsiella tardaInfection in the FlounderParalichthys olivaceus

Journal of Aquatic Animal Health (1996)

Gang‐Joon Heo Jeong‐Ho Kim

Efficacy of norfloxacin was evaluated in laboratory and field studies for control of Edwardsiella tarda infection in the flounder Paralichthys olivaceus. In disc diffusion tests, five E. tarda strains showed high sensitivity to norfloxacin. Minimum inhibitory concentrations of norfloxacin against the five isolates were approximately 0.016–0.031 μg/mL. In laboratory studies in which flounder were challenged with E. tarda, a significant (P < 0.05) reduction in mortality was observed among fish receiving norfloxacin in feed at 100 mg/kg body weight (or more) daily for 3 d compared with mortality among nonmedicated controls. Similar results were achieved when 100 mg norfloxacin/kg body weight was used in field trials.

Edwardsiella tarda

Paralichthys

Olive flounder

10.1577/1548-8667(1996)008<0255:ceonft>2.3.co;2

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Molecular characterization of antimicrobial-resistant Citrobacter freundii isolated from pet turtles in Korea

Journal of Preventive Veterinary Medicine (2022)

Masimbule Wickramanayake Liyana Silva Gang‐Joon Heo

Citrobacter freundii

10.13041/jpvm.2022.46.3.121

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