In order to compare pregnancy outcomes following fresh and frozen embryo transfer after in vitro fertilization (IVF), a retrospective analysis of data from the Royal North Shore IVF Programme was performed. Six hundred and sixty seven embryo transfers following routine IVF were performed during 1991 and 1992. Four hundred and twenty fresh embryo transfers were performed during that period, resulting in a clinical pregnancy rate of 21%. In comparison, 247 frozen transfers, where the initial procedure was routine IVF, were performed, resulting in a clinical pregnancy rate of 16.6%. This difference was not significant. When varying numbers of transferred embryos in the 2 groups were taken into account, there was a significant difference in the proportion of ongoing viable fetuses per embryo returned for 1991, but not for 1992. Although there were a greater number of abortions and ectopic pregnancies in the fresh transfer group, these differences did not achieve statistical significance. The implications of improving results from frozen embryo transfer are discussed.
A total of 5461 insemination cycles with frozen donor semen has been analysed for 8 of the larger AID services in Australia. Cumulative pregnancy rate, calculated by life-table analysis, showed that 50% of all patients are pregnant after 6 cycles of insemination and 64% of all patients are pregnant after 12 cycles of insemination. Pregnancy rate was significantly higher in the first 3 cycles, declined in the next 3 cycles and was further reduced in the last 6 cycles of insemination. An average of 10% of all insemination cycle were anovular, but the proportion of anovular cycles was significantly lower in the first 2 cycles of insemination. There was no significant difference in cumulative pregnancy rates over the first 6 cycles of insemination in clinics using cervical mucus scoring or LH assay for detection of ovulation. An average of 12% of all pregnancies obtained by AID resulted in miscarriage.
Conclusions: Consistent with other research, negative mood states appear to effect risk behavior.Heightened emotional distress and particularly moods of depression, anger and fatigue appear to operate in two ways; by influencing patient estimates of the likelihood of a multiple pregnancy and also by influencing perceptions of risk associated with choosing 2ET over SET or 3ET over 2ET.Higher baseline infertility stress may increase receptivity for a twin pregnancy, but stress appeared to have little direct impact on risk behavior or perceptions of risk.However, a preexisting desire for a multiple pregnancy appears to increase risk taking in terms of leading women to choose more risky options for embryo transfrer.
Journal Article Measurement of human embryo-derived platelet-activating factor (PAF) using a quantitative bioassay of platelet aggregation Get access M. Collier, M. Collier Human Reproduction Unit Royal North Shore Hospital of SydneySt Leonards NSW 2065 Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar C. O'Neill, C. O'Neill 1 Human Reproduction Unit Royal North Shore Hospital of SydneySt Leonards NSW 2065 Australia 1To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. Ammit, A. J. Ammit Human Reproduction Unit Royal North Shore Hospital of SydneySt Leonards NSW 2065 Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar D. M. Saunders D. M. Saunders Human Reproduction Unit Royal North Shore Hospital of SydneySt Leonards NSW 2065 Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 5, Issue 3, 1 April 1990, Pages 323–328, https://doi.org/10.1093/oxfordjournals.humrep.a137098 Published: 01 April 1990 Article history Received: 20 September 1989 Accepted: 04 December 1989 Published: 01 April 1990
1. A highly significant inverse relationship was found between blood pressure in untreated hypertensive subjects in late pregnancy and birth weight. 2. Reversal of this intrauterine growth retardation was achieved in 19 patients by treatment of hypertension with oxprenolol. 3. No adverse effects from oxprenolol were found in the patients or in their babies.
Objectives: The discovery of a variant strain of Chlamydia trachomatis (Ct) in Sweden has raised awareness of its possible undetected spread in the UK. The assays that fail to detect this variant are widely used in this country. This study aimed to determine if this variant is circulating in the UK. Method: 1680 genital specimens tested negative by the Roche assays were retested by Aptima Combo2. Discordant results were sequenced to check for the deletion variant. Results: Of 1680 specimens tested, 29 were candidates for sequencing: 16 were negative for the variant, 11 failed to amplify, and 2 were lost. Discussion: No Ct deletion variants were found in the UK. If it is circulating, then the prevalence is low (0–0.77%), but even a low level cannot be ignored. The system we describe is simple and suitable for rapid response and phasing of surveillance to match an unknown level of threat if other variants emerge.
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