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Yanying Kong

Guangzhou Medical University

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Huacheng Yan

Guangzhou Center for Disease Control and Prevention

Qiuju Peng

Dalian Ocean University

Lei Shi

Chinese Academy of Sciences

Jiaqiang Zheng

General Hospital of Guangzhou Military Command

Zhao Shu-jin

South China University of Technology

Mukun Huang

General Hospital of Guangzhou Military Command

Yuguan Wen

Guangzhou Medical University

Li Xie

Children's Hospital of Chongqing Medical University

Yongpan Zhao

Northwest A&F University

Jin Li

Dalian Polytechnic University

Cooperative Institutions

General Hospital of Guangzhou Military Command

Southern Medical University

Chinese Academy of Sciences

Sun Yat-sen University

Third Affiliated Hospital of Southern Medical University

Nanfang Hospital

University of Chinese Academy of Sciences

Peking University

South China University of Technology

Guangdong Pharmaceutical University

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reprogram metabolism of infiltrated t cells in tumor microenvironment to improve immunotherapy outcomes

Advances in Biochemistry and Biotechnology (2018)

Nan Lü Shanshan Zhang Yanying Kong Xiaolin Liang Laiyou Wang

Cancer Immunotherapy

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Citations (0)

Association between CYP17A1 rs3824755 and rs743572 gene polymorphisms and Alzheimer’s disease in the Chinese Han population

Neuroscience Letters (2016)

Li Xie Huacheng Yan Lei Shi Yanying Kong Mukun Huang

Chinese population

Genetic Association

Association (psychology)

Genome-wide Association Study

10.1016/j.neulet.2016.02.053

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Citations (7)

Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer’s disease via activation of adenosine A1 receptor

Neuroscience Letters (2020)

Yanying Kong Qiuju Peng Nan Lv Jin Yuan Zhirong Deng

Spontaneous alternation

Paeoniflorin

Adenosine A1 receptor

Elevated plus maze

10.1016/j.neulet.2020.135016

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Citations (34)

The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population

Neuroscience Letters (2020)

Qiuju Peng Yanying Kong Lei Shi Yuan Yan Yuan Yao

10.1016/j.neulet.2020.135361

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CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer’s disease in the Chinese Han population

Neuroscience Letters (2015)

Huacheng Yan Yanying Kong Baoxia He Mukun Huang Jian Li

Apolipoprotein E

10.1016/j.neulet.2015.03.024

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The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population

Medicine (2016)

Jiaqiang Zheng Huacheng Yan Lei Shi Yanying Kong Yongpan Zhao

Background: The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences the final step in the biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms in CYP19A1 could influence the risk of AD by altering the expression of CYP19A1. The ε4 allele of the apolipoprotein E (APOE) gene, which is the most significant known genetic risk factor for AD, may mask the effects of other loci. Methods: To assess the potential association of CYP19A1 gene polymorphisms with the risk of AD, we conducted a case–control study in a Chinese Han population by recruiting 463 cases, including 207 patients diagnosed with AD and 256 healthy people matched for sex and age. Results: In APOE ε4 carriers, the distributions of the G allele and the AG + GG genotype of CYP19A1 rs3751592 in patients differed significantly (P < 0.05) from those in healthy people. However, no difference was observed in the distribution of CYP19A1 rs1065778 between the patient and control populations, regardless of their APOE ε4 status. Conclusion: The results demonstrated that the rs3751592 A/G polymorphism of the CYP19A1 gene was associated with the incidence of AD in a Chinese Han population, which suggests that CYP19A1 rs3751592 is a predisposing genetic factor for AD.

Apolipoprotein E

10.1097/md.0000000000004742

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Citations (18)

CYP19A1 rs2470152 polymorphism increases susceptibility to depression in Chinese Han population

Neuroscience Letters (2019)

Yanping Yang Huacheng Yan Yanying Kong Min Liu Qiuju Peng

Depression

10.1016/j.neulet.2019.134490

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Citations (4)

CX3CL1 rs170364 gene polymorphism has a protective effect against major depression by enhancing its transcriptional activity

Brain Research (2020)

Qiuju Peng Lei Shi Yanying Kong Yuan Yan Jielin Zhan

CX3CL1

SNP

10.1016/j.brainres.2020.146801

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Citations (5)