Enjun Zhu

Capital Medical University

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Yongqiang Lai

Beijing Anzhen Hospital

Jinwei Zhang

University of Exeter

Senchun Chai

Beijing Institute of Technology

Fang-jiong Huang

Capital Medical University

Xiaohai Ma

Beijing Friendship Hospital

Shengwei Wang

Wuyi University

Xiaoli Zhang

Capital Medical University

Xiang Li

Second Affiliated Hospital of Nanchang University

Yi-Xi Zou

Capital Medical University

Yuan Zhou

Capital Medical University

Cooperative Institutions

Capital Medical University

Beijing Anzhen Hospital

Beijing Institute of Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing Institute of Water

Chinese Academy of Sciences

Huazhong University of Science and Technology

Peking University

Sun Yat-sen University

Beijing Chao-Yang Hospital

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Predictive value of viable myocardium of papillary muscle-ventricular wall complex for improvement in moderate ischemic mitral regurgitation

CJC Open (2024)

Zhipeng Wei Enjun Zhu Zhiyong Shi Tong Tan Ke Zhang

Papillary muscle

Functional mitral regurgitation

10.1016/j.cjco.2024.11.021

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Citations (0)

Association between omentin-1 expression in human epicardial adipose tissue and coronary atherosclerosis

Cardiovascular Diabetology (2016)

Yu Du Qingwei Ji Lun Cai Fang-jiong Huang Yongqiang Lai

Omentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well as other obesity-related disorders. This study investigated the association between omentin-1 expression in human epicardial adipose tissue (EAT) and coronary atherosclerosis. Serum samples, and paired biopsies from EAT and subcutaneous adipose tissue (SAT), were obtained from patients with and without coronary artery disease (CAD, n = 28 and NCAD, n = 12, respectively) during elective cardiac surgery. Coronary angiography was performed to identify CAD presence. Serum omentin-1 and adiponectin levels were measured by ELISA. mRNA expression of omentin-1 and adiponectin was detected in adipose tissue by quantitative real-time PCR, and omentin-1 protein expression was evaluated by immunohistochemistry. Correlation and multivariate linear regression analyses were performed to determine the association between omentin-1 expression and clinical risk factors. mRNA and protein expression of omentin-1 were higher in EAT than paired SAT in patients with CAD and NCAD. Compared with NCAD patients, CAD patients had lower omentin-1 and adiponectin mRNA levels in EAT and serum levels as well as lower omentin-1 protein levels. Among patients with CAD, omentin-1 expression was lower in EAT surrounding coronary segments with stenosis than those without stenosis, in terms of mRNA and protein, whereas adiponectin mRNA level in EAT did not seem to differ between stenotic and non-stenotic coronary segments in CAD patients. In multivariate linear regression analysis, CAD was an independent predictor of EAT omentin-1 mRNA expression (beta = −0.57, 95 % CI −0.89 to −0.24; P = 0.001) and serum omentin-1 levels (beta = −0.35, 95 % CI −0.67 to −0.03; P = 0.036). Circulating and EAT-derived omentin-1 levels were reduced in patients with CAD. Omentin-1 expression in patients with CAD was lower in EAT adjacent to coronary stenotic segments than non-stenotic segments.

Coronary atherosclerosis

10.1186/s12933-016-0406-5

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Prevalence of Coronary Artery Disease in Patients Undergoing Valvular Heart Surgery

The Heart Surgery Forum (2023)

Changwei Ren Jianbo Yu Jinwei Zhang Shengwei Wang Enjun Zhu

Background: The risk of coronary artery disease (CAD) in different valve dysfunction has been unclear. Methods: We reviewed patients, who underwent valve heart surgery and coronary angiography from 2008 to 2021, at our center. Results: A total of 7,932 patients were included in the present study, and 1,332 (16.8%) had CAD. The mean age of the study cohort was 60.5±7.9 years, and 4,206 (53.0%) were male. CAD was 21.4% in aortic disease, 16.2% in mitral valve disease, 11.8% in isolated tricuspid valve disease, and 13.0% in combined aortic and mitral valve disease. Patients with aortic stenosis were older than those with regurgitation (63.6±7.4 years vs. 59.5±8.2 years, P < 0.001), and the CAD risks also were higher (28.0% vs. 19.2%, P < 0.001). The age difference was minimal (60.6±8.2 years vs. 59.5±6.7 years, P = 0.002) between patients with mitral valve regurgitation and stenosis, but the risks of CAD were twice high in regurgitation (20.2% vs. 10.5%, P < 0.001). When the type of valve impairment was not considered, non-rheumatic etiology, advanced age, male sex, hypertension, and diabetes were independent predictors of CAD. Conclusion: In patients undergoing valve surgery, the prevalence of CAD was influenced by conventional risk factors. Importantly, CAD also was associated with the type and etiology of valve diseases.

valvular heart disease

Etiology

10.1532/hsf.5331

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Citations (3)

Predictors of moderate to severe ischemic mitral regurgitation after myocardial infarction: a cardiac magnetic resonance study

European Radiology (2021)

Chen Zhang Lei Zhao Enjun Zhu Paul Schoenhagen Jie Tian

Neuroradiology

Univariate analysis

10.1007/s00330-020-07658-z

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Citations (8)

Deep multi-scale dilated convolution network for coronary artery segmentation

Biomedical Signal Processing and Control (2024)

Yue Qiu Senchun Chai Enjun Zhu Nan Zhang Gaochang Zhang

Convolution (computer science)

10.1016/j.bspc.2024.106021

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Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease

Cardiovascular Diabetology (2017)

Qingwei Ji Jianwei Zhang Yu Du Enjun Zhu Zhijian Wang

Previous studies have demonstrated that secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose and triglyceride metabolism in patients with stable coronary artery disease. In the present study, we investigated human epicardial adipose tissue (EAT)-derived and circulating SFRP4 levels in patients with coronary artery disease (CAD). Plasma samples and adipose biopsies from EAT and subcutaneous adipose tissue (SAT) were collected from patients with CAD (n = 40) and without CAD (non-CAD, n = 30) during elective cardiac surgery. The presence of CAD was identified by coronary angiography. SFRP4 mRNA and protein expression levels in adipose tissue were detected by quantitative real-time PCR and immunohistochemistry, respectively. Plasma SFRP4 concentrations were measured by an enzyme-linked immunosorbent assay (ELISA). Correlation analysis and multivariate linear regression analysis were used to determine the association of SFRP4 expression with atherosclerosis as well as clinical risk factors. SFRP4 mRNA and protein expression levels were significantly lower in EAT than in paired SAT in patients with and without CAD (all P < 0.05). Compared to non-CAD patients, CAD patients had higher SFRP4 expression levels in EAT (both mRNA and protein levels) and in plasma. Multivariate linear regression analysis showed that CAD was an independent predictor of SFRP4 expression levels in EAT (beta = 0.442, 95% CI 0.030–0.814; P = 0.036) and in plasma (beta = 0.300, 95% CI 0.056–0.545; P = 0.017). SAT-derived SFRP4 mRNA levels were independently associated with fasting insulin levels (beta = 0.382, 95% CI 0.008–0.756; P = 0.045). In addition, plasma SFRP4 levels were positively correlated with BMI (r = 0.259, P = 0.030), fasting insulin levels (r = 0.306, P = 0.010) and homeostasis model assessment of insulin resistance (HOMA-IR) values (r = 0.331, P = 0.005). EAT-derived and circulating SFRP4 expression levels were increased in patients with CAD. EAT SFRP4 mRNA levels and plasma SFRP4 concentrations were independently associated with the presence of CAD.

Dyslipidemia

10.1186/s12933-017-0612-9

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Citations (36)

Segmentation of Aorta with Aortic Dissection based on Centerline and Boundary Distance

2022 41st Chinese Control Conference (CCC) (2022)

Zhaozhan Song Senchun Chai Enjun Zhu

Segmentation of the aorta is important for the diagnosis and treatment of aortic disease. However, low image contrast and blurred boundaries between the aortic region and surrounding tissues can significantly affect segmentation performance. Based on 3D-UNet with spatial attention module, this paper proposes a multi-branch shape-aware segmentation network named CDM-Net, which transforms the traditional segmentation problem into a regression problem of distance transformation map and centerline heatmap. A new inference method based on regression is also proposed, the prediction of our network can be combined with the predictions of other networks. Without changing other segmentation metrics (Dice, ASD), the clDice of the combined method improves by 1.5%. Our proposed method can improve the connectivity of aorta segmentation results, paving the way for accurate centerline extraction and multiplanar reconstruction in the future.

10.23919/ccc55666.2022.9902528

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Citations (2)

Developing a Versatile Multiscale Therapeutic Platform for Osteosarcoma Synergistic Photothermo-Chemotherapy with Effective Osteogenicity and Antibacterial Capability

ACS Applied Materials & Interfaces (2022)

Yunlong Ma Lan Jiang Jie Hu Enjun Zhu Nan Zhang

Osteosarcoma is a devastating malignant neoplasm that seriously threatens human health. After an osteosarcoma resection, the simultaneous treatment of tumor recurrence, postoperative infection, and large bone loss remains a formidable challenge clinically. Herein, a versatile multiscale therapeutic platform (Fs-BP-DOX@PDA) is engineered based on NiTi alloys with versatile properties for near-infrared (NIR)-mediated osteosarcoma synergistic photothermo-chemotherapy, bone regeneration, and bacterial elimination. First, an intriguing method for fabricating groovelike micro-nanostructures (Fs-NiTi) through femtosecond laser direct writing to enhance osseointegration with strong contact guidance is proposed. Then, black phosphorus (BP) nanosheets as gratifying photothermal conversion agents, osteogenetic agents, and a drug delivery platform are decorated on Fs-NiTi to construct multiscale hierarchical structures (Fs-BP). Finally, the polydopamine (PDA) modification is utilized to enhance the photothermal performance, biocompatibility, and chemical stability of doxorubicin (DOX)-loaded Fs-BP and endow NIR/pH-dual-responsive DOX release properties. Fs-BP-DOX@PDA effectively induces tumor cell (Saos-2 and MDA-MB-231) death in vitro, completely eradicates osteosarcoma in mice, and observably promotes bone-regeneration bioactivity. Furthermore, it possesses prominent antibacterial efficiencies toward Staphylococcus aureus (99.2%) and Pseudomonas aeruginosa (99.6%). Overall, this work presents a smart comprehensive fabrication methodology to construct a versatile multiscale therapeutic platform for multimodal osteosarcoma treatment and biomedical tissue engineering.

Biocompatibility

10.1021/acsami.2c10772

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Citations (23)

Effect of Pioglitazone on In-Stent Restenosis after Coronary Drug-Eluting Stent Implantation: A Meta-Analysis of Randomized Controlled Trials

PLoS ONE (2014)

Mingduo Zhang Yuhui Zhang Enjun Zhu Shi-bin Qiao Shuzheng Lv

In-stent restenosis (ISR) remains a common life-threatening complication and some studies have shown that pioglitazone can reduce the incidence of ISR in patients with drug-eluting stents (DES) implantation. We conducted a meta-analysis to assess the effect of pioglitazone in preventing ISR after DES implantation.

Pioglitazone

Clinical endpoint

Coronary stent

10.1371/journal.pone.0109614

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Citations (2)

The association between myocardial scar and the response of moderate ischemic mitral regurgitation to isolated coronary artery bypass grafting

Annals of Translational Medicine (2021)

Enjun Zhu Chen Zhang Shengwei Wang Xiaohai Ma Yongqiang Lai

The factors that associated with the response of moderate ischemic mitral regurgitation (IMR) to isolated coronary artery bypass grafting (CABG) remain unclear. This study aims to evaluate whether left ventricular (LV) myocardial scar assessed by cardiovascular magnetic resonance (CMR) is associated with the outcome of moderate IMR after isolated CABG.Forty-six patients with coronary artery disease (CAD) and moderate IMR who underwent isolated CABG between January 2014 and February 2019 in Anzhen Hospital Affiliated to Capital Medical University were enrolled in this case-control study. All patients underwent CMR and echocardiography before surgery. Patients were classified into two groups according to the severity of IMR 1 year after CABG: an improved group (no or mild IMR) and an unimproved group (moderate or severe IMR). Univariate and multivariate logistic regression analyses were used to assess the association between individual variables and unimproved IMR at 1-year post-CABG.Compared to patients in the improved group, the patients in the unimproved group had a significantly greater amount of LV myocardial scar (18.0%±9.5% vs. 30.8%±11.2%, P<0.001). In the multiple logistic regression model, after adjustment for age, sex, and body mass index, only LV myocardial scar (OR: 0.89, 95% CI: 0.83-0.96, P=0.001) was independently associated with unimproved IMR after isolated CABG. Furthermore, there was no difference in the 3-year overall survival rates between the two groups (92.3% vs. 90.3%, P=0.46). In addition, patients in the unimproved group had a higher New York Heart Association (NYHA) classification (P=0.01) and more major adverse cardiac events such as MI, angina pectoris, and readmission for heart failure (P=0.03).A greater amount of preoperative LV myocardial scar was associated with unimproved moderate IMR after isolated CABG. Measuring preoperative LV myocardial scar is helpful to predict post-operative outcome and determine optimal surgery in patients with moderate IMR.

10.21037/atm-21-3622

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Citations (2)