Yu. Harahuts

Taras Shevchenko National University of Kyiv

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Nataliya Kutsevol

Taras Shevchenko National University of Kyiv

Vasyl Chumachenko

Taras Shevchenko National University of Kyiv

A. P. Naumenko

Taras Shevchenko National University of Kyiv

N Yu Lukianova

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

Irina Shton

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

ВФ

В Ф Чехун

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

ОN

О. Nadtoka

Taras Shevchenko National University of Kyiv

N. Melnyk

Ivano-Frankivsk National Medical University

D M Storchai

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

ОВ

О. В. Ващенко

Institute for Scintillation Materials

Cooperative Institutions

National Academy of Sciences of Ukraine

Taras Shevchenko National University of Kyiv

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

Institute for Scintillation Materials

Institute for Single Crystals

B. Verkin Institute for Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

University of Arizona

Institut Charles Sadron

Université de Strasbourg

Centre National de la Recherche Scientifique

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The investigation of nanosystems branched polymer/nanogold in the region of conformational transition of a polymer matrix

Polymer journal (2018)

Vasyl Chumachenko Yu. Harahuts Nataliya Kutsevol N. Melnyk О. Nadtoka

Matrix (chemical analysis)

10.15407/polymerj.40.01.036

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Citations (1)

Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin

Ukrainian Journal of Physics (2018)

Nataliya Kutsevol A. P. Naumenko Vasyl Chumachenko Oleg A. Yeshchenko Yu. Harahuts

Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. The decrease of the antitumor efficiency of the hybrid ternary nanosystem Polymer/AgNPs/cis-Pt in comparison with the Polymer/cis-Pt system is discussed.

Silver nanoparticle

Carboxylate

10.15407/ujpe63.6.513

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Citations (8)

The influence of the molecular structure of copolymers Dextran-poly-N-isopropylacrylamide on conformational transition characteristics

Polymer journal (2017)

Vasyl Chumachenko Nataliya Kutsevol Yu. Harahuts V.A. Ryzhko N. Melnyk

Poly(N-isopropylacrylamide)

10.15407/polymerj.39.02.122

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Citations (0)

In vitro study of toxicity of hybrid gold-polymer composites

Molecular Crystals and Liquid Crystals (2018)

Nataliya Kutsevol Yu. Harahuts Irina Shton Т. Borikun D M Storchai

The purpose of the present study was to evaluate the toxicity of gold nanoparticles (AuNPs) incorporated into branched polymer matrices Dextran-graft-Polyacrylamide on cancer cells of different origin. The study was performed on breast cancer MCF-7 cell line and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively and MT-4 (human T-cell leukemia) cell line. All cells were treated with copolymer D-g-Pаа alone and nanosystem, containing D-g-Pаа/AuNPs. Results of our study proved low toxicity of examined compounds even in high doses. Nanosystems, containing AuNP exhibited more pronounced cytotoxic effects on cancer cells in comparison to D70-Pаа alone.

10.1080/15421406.2018.1542078

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Citations (7)

Star-like dextran-graft-pnipam copolymers. Effect of internal molecular structure on the phase transition

Journal of Molecular Liquids (2017)

Vasyl Chumachenko Nataliya Kutsevol Yu. Harahuts Michel Rawiso А. І. Маринін

Poly(N-isopropylacrylamide)

Refractometry

10.1016/j.molliq.2017.02.098

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Citations (28)

Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

International Journal of Polymer Science (2017)

Г. Д. Телегеев Nataliya Kutsevol Vasyl Chumachenko A. P. Naumenko P. Telegeeva

Drug targeting to specific organs and tissues is one of the crucial endeavors of modern pharmacotherapy. Controlled targeting at the site of action and reduced time of exposure of nontargeted tissues increase the efficacy of the treatment and reduce toxicity and side effects, improving compliance and convenience. Nanocarriers based on the branched copolymers dextran-graft-polyacrylamide were synthesized and characterized and were tested on phagocytic cells. It was shown that these nanoparticles are actively captured by phagocytic cells and that they are not cytotoxic. The polymer nanoparticles loaded with cisplatin at different concentrations from 0.1 to 10 μ g/mL yielded dose-dependent decrease in viability of chronic myelogenous leukemia and histiocytic lymphoma cells. The lowest percentage of viable cells was observed for lymphoma cells (22%). Taking into account the fact that our nanoparticles will act mainly on malignant phagocytic cells and do not affect healthy cells, they can thus potentially be used for the therapeutic treatment of tumor cells having phagocytic activity. The effect of nanosilver on cell viability was lower than the one of polymer/cisplatin composite. The data from the cytotoxic studies indicate that nanosilver induces toxicity in cells. However, when the copolymers were conjugated to both nanosilver and cisplatin, such a nanosystem displayed less cytotoxic effect compared to the conjugates of dextran-polyacrylamide and cisplatin.

Nanocarriers

Viability assay

Polyacrylamide

10.1155/2017/4929857

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Citations (34)

Impact of surface properties of branched polyacrylamides onto model lipid membranes of various compositions

Molecular Crystals and Liquid Crystals (2018)

Nataliya Kutsevol Yu. Harahuts Vasyl Chumachenko L. V. Budianska О. В. Ващенко

Branched dextran-graft-polyacrylamide copolymers with different surface properties (charged and uncharged, pure and loaded by Ag or Au nanoparticles) were created in order to drug delivery usage. By means of differential scanning calorimetry, membranotropic action of the polymers was revealed in a set of model lipid membranes, both charged and uncharged. It was observed that negatively charged membranes were more sensitive to the polymers introduction then uncharged one. The most pronounced membrantoropic effects resulted from membrane surface disturbance, which is due to significant contribution and specificity of surface interaction in the systems studied.

Synthetic membrane

Polyacrylamide

10.1080/15421406.2018.1542079

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Citations (3)

New hybrid composites for photodynamic therapy: synthesis, characterization and biological study

Applied Nanoscience (2018)

Nataliya Kutsevol A. P. Naumenko Yu. Harahuts Vasyl Chumachenko Irina Shton

Nanochemistry

Absorbance

10.1007/s13204-018-0768-y

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