Andrey V. Tikhonov

Research Institute of Obstetrics and Gynecology named after D.O. Ott

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Olga G. Chiryaeva

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Olga A. Efimova

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Oleg S. Glotov

City Hospital No. 40

Elvira V. Isakova

АS

Аndrey S. Glotov

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Olga Malysheva

Cornell University

ТВ

Т. В. Вавилова

Federal Almazov North-West Medical Research Centre

Vera S. Dudkina

Research Institute of Obstetrics and Gynecology named after D.O. Ott

L Petrova

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Anna A. Pendina

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Cooperative Institutions

Research Institute of Obstetrics and Gynecology named after D.O. Ott

St Petersburg University

Russian Academy of Sciences

Federal Almazov North-West Medical Research Centre

City Hospital No. 40

Academy of Medical Sciences

S. M. Kirov Military Medical Academy

Research Centre for Medical Genetics

International Centre for Reproductive Health

Surgut State University

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A comparative cytogenetic analysis of miscarriages following natural conception and assisted reproductive technologies

Journal of obstetrics and women s diseases (2012)

Olga G. Chiryaeva Anna Andreevna Pendina Andrey V. Tikhonov Olga A. Efimova L Petrova

The present paper summarizes results of cytogenetic study of 679 chorionic samples from miscarriages following natural conception and assisted reproductive technologies. Frequency and spectrum of karyotype pathology and its correlation with maternal age and term of gestation are analyzed. The results are compared and discussed with relevant other studies

Assisted Reproductive Technology

Products of conception

10.17816/jowd613132-140

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Citations (4)

Telomeres as dynamic structures of human genome: the effect of endogenous and exogenous factors

Ecological genetics (2022)

Mikhail I. Krapivin Yanina M. Sagurova Olga A. Efimova Andrey V. Tikhonov Anna A. Pendina

In this review, we summarize data on the structural and functional characteristics of human telomeres and analyze how endo- and exogenous factors influence telomere length. We elucidate the history of telomere investigation, describe their structure and functions, methods of their study. We also characterize the mechanisms of telomere lengthening and shortening. We discuss in detail endo- and exogenous factors affecting telomere length during gametogenesis, embryogenesis and in the postnatal period of human development. We describe how oxidative stress influences telomere length through guanine oxidation, single-strand breaks in DNA, decrease of telomerase activity and suppression of recombination in telomeric sequences. We conclude that the multidirectional effect of various factors, both sporadic and determined by the developmental program, ensures the dynamic equilibrium of telomere length. A shift in this balance due to increased influence of one or several factors can lead to telomere lengthening or shortening. Understanding the mechanisms underlying the telomere length changes and the critical periods of exposure to both protective and negative factors is important to contribute to the knowledge about telomere functions and to develop approaches of telomere length correction.

Telomere-binding protein

10.17816/ecogen106539

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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

Reproductive and Developmental Medicine (2022)

Irina Trofimova Ziravard N. Tonyan Alsu Saifitdinova Julia Loginova Anna A. Kinunen

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous chromosomes. Translocations are facilitated by the creation of quadrivalent structures during the first meiotic division, which are characterized by the length of the translocated and centric segments, asymmetry, and the presence of terminal breakpoints, all of which may impact segregation mode. Here, we report a rare case of multiple reciprocal translocations within a single family. This includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their quadrivalents. The obtained results will be of interest to fundamental biology, as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

Breakpoint

Reciprocal

10.1097/rd9.0000000000000041

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