B Knoll

Hungarian Academy of Sciences

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J. Knoll

United States Department of Agriculture

József Tı́már

Semmelweis University

J. Knoll

Semmelweis University

Susanna Gyarmati

Semmelweis University

K. Kelemen

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Ildikó Miklya

Semmelweis University

Sevil Yaşar

Johns Hopkins Medicine

E. S. Vizi

Hungarian Academy of Sciences

L Barna

Indiana University Bloomington

Zs. Gyarmati

Semmelweis University

Cooperative Institutions

Semmelweis University

Hungarian Academy of Sciences

HUN-REN Institute of Experimental Medicine

Eötvös Loránd University

Albert Einstein College of Medicine

Fujimoto Pharmaceutical Corporation (Japan)

Nathan Kline Institute for Psychiatric Research

Heidelberg University

Gedeon Richter (Hungary)

University of Zurich

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The effect of (-) deprenyl (selegiline) on different behavioral changes induced by dopamine agonists in the rat.

PubMed (1988)

József Tı́már B Knoll J. Knoll

The effect of (-) deprenyl was investigated both on the stereotyped behavior and on other types of activities induced by various dopamine (DA) agonists. (-) Deprenyl was given in a single dose, 1 h prior to the DA agonists. 1-2 mg/kg sc (-) deprenyl decreased the stereotypy induced by amphetamine (AMPH, 2.5 mg/kg sc), but 20 mg/kg was needed to reduce the stereotypy-inducing effect of apomorphine (APO, 0.3 mg/kg sc). The stereotypy-inducing effect of phenyl-ethyl-amine (PEA, 40 mg/kg sc) was significantly enhanced by 0.25 mg/kg sc (-) deprenyl pretreatment. The PEA or AMPH-induced increase in the horizontal activity (locomotion) and the vertical activity (rearing) remained unchanged after a single dose of (-) deprenyl, showing that this drug acts primarily on the nigro-striatal dopaminergic system.

Stereotypy

Selegiline

Apomorphine

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Citations (2)

The effect of para-Br-methamphetamine on aggressive behaviour [proceedings].

PubMed (1977)

B Knoll

Methamphetamine

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