S Grădinaru

Carol Davila University of Medicine and Pharmacy

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i-10 index

Research Trends

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Co-Authors

Radu Ciuluvică

Carol Davila University of Medicine and Pharmacy

E Ungureanu

Carol Davila University of Medicine and Pharmacy

R Borcan

Spitalul Universitar de Urgență Elias

S Oprescu

Carol Davila University of Medicine and Pharmacy

Aida Geamănu

Carol Davila University of Medicine and Pharmacy

S Neagu

National Institute for Research and Development in Forestry "Marin Drăcea"

CŞ

C Şavlovschi

Carol Davila University of Medicine and Pharmacy

M Totir

Carol Davila University of Medicine and Pharmacy

Narcis Zarnescu

Carol Davila University of Medicine and Pharmacy

D. Dumitrescu

Carol Davila University of Medicine and Pharmacy

Cooperative Institutions

Clinical Emergency Hospital Bucharest

Carol Davila University of Medicine and Pharmacy

Emergency University

Bucharest Emergency University Hospital

Amita Health St. Mary's Hospital

Spitalul Universitar de Urgență Elias

Victor Babeș University of Medicine and Pharmacy Timișoara

Ovidius University

Institutul Cantacuzino

University of Bucharest

Author Statistics

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Citation

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Research Field

Computer Tomograph (CT) imaging of mandibular anatomical substrate in animal model restored with nanostructured hydroxyapatite compounds.

PubMed (2015)

Radu Ciuluvică S Grădinaru Mădalină Popescu Roxana Mioara Piticescu Romică Cergan

This study was meant to test a new type of bone graft on an animal model. This material was a nanostructured hydroxyapatite.

Mandible (arthropod mouthpart)

Monobasic acid

Animal model

X-ray microtomography

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Citations (1)

Topographic measurements of eyelids and orbit in enucleated eyes with hydroxyapatite integrated implant versus PMMA implant.

PubMed (2014)

S Grădinaru M Totir Raluca Iancu C Leasu Ștefan Pricopie

This study reports our results relating to palpebral eyelid fissure and orbital measurements following evisceration with orbital implantation of hydroxyapatite integrated implant and PMMA implant.This study is a prospective study of 43 patients that underwent evisceration for different ocular affections at University Emergency Hospital Bucharest, Ophthalmology department between January 2009 and September 2010 (Group A comprising of twenty patients had the coralline hydroxyapatite implant -Integrated Ocular Implants, USA and Group B comprising of twenty-three received non-integrated PMMA ocular implants) .The outcomes measured were the degree of exo /enophthalmos, horizontal eyelid fissure and palpebral fissure height at 4 years after surgical intervention related to measurement to the contralateral eye.Horizontal eyelid fissure (HEF) was suffering a shortening of 7.4% in the group B versus the contralateral eye, and only 1.9% in the group A related to the contralateral eye. Eyelid fissure height was greater in the group B with 5.2% regarding the contralateral eye, and 1.2% in group A. The degree of enophthalmia was higher in the group B of 4 mm versus the contralateral eye and lower in group A 1.5 mm regarding the contralateral eye.. Although a hydroxyapatite implant may be not as economic as a PMMA implant, a patient must be warned about the effect on its ocular structures in time and that cosmetic appearance over years will change more dramatically than in the fellow normal eye. Therefore preoperative counseling of the patient is crucial in long term patient satisfaction.

Evisceration (ophthalmology)

Palpebral fissure

Enophthalmos

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Citations (1)

[Amyand's hernia--a clinical case].

PubMed (2010)

C Şavlovschi C Brănescu Dragoș Șerban Corneliu Tudor C Găvan

Amyand's hernia, a rare entity in the surgical pathology, presupposes the presence of the vermiform appendix inside a inguinal hernia sac (1). The hernia sac peritonitis by appendix swelling is even more rare, very few cases being presented in the surgical literature (1). The preoperatory diagnosis of Amyand's hernia is therefore very difficult. We herein present the case of a 71-year old male patient, operated on an emergency basis for hernia, which eventually turned out to be Amyand's hernia, a case which determined us to research the literature dedicated to this topic.

Vermiform

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Citations (16)

CAUSES OF DECEASE IN NECROTIZING ACUTE PANCREATITIS

Pancreas (2005)

E C Petcu S Neagu Radu Costea C Dumitrescu V Badea

Background: Despite the improvements in establishing early diagnosis, of medical treatments and surgical techniques, severe acute pancreatitisstill remains a disease with a high morbidity and mortality with serious social and economical consequences. Patients and Method: We present a retrospective analysis of 82 consecutive patients with necrotizing acute pancreatitis (CT, intraoperative or necroptic diagnosis) with age in range 26-86 (with a median of 56). We have analyzed the following parameters: age, gender, associated pathology, etiology, biochemical values at admission and at 48 hours, interval from clinical onset to admission and interval from admission to surgery. We have compared two patients groups: favorable evolution and deceased. Results: Multivariate statistical analysis has showed a higher mortality after age of 50 for men and after age of 60 for women. The overall mortality was 56%. Evaluation of cause of necrotizing acute pancreatitis showed a higher risk of death for unkown etiology (75%) versus biliary or alchohol etiology (50%). Conclusions: We have found that age related gender, unkown etiology, associated pathology (stroke, ischemic heart disease, chronic hepatitis), serum glucose level >200 mg/dl and creatinine >2 mg/dl and early surgery (at admission) imply a higher risk of death for patients with severe acute pancreatitis.

Etiology

10.1097/01.mpa.0000193742.80404.23

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Spontaneous hemoperitoneum by the rupture of a large stromal gastric tumour

Romanian Journal of Medical Practice (2016)

R Borcan S Grădinaru M. STOICEA Erika ADAM Adriana Elena Nica

The 48 year old patient, admitted to the Clinic IV for Digestive Surgery – Emergency University Hospital, presenting with symptoms of acute abdomen: intense diffuse abdominal pain, paleness of tissue and mucous membranes, nausea and vomiting. Pain started abruptly and agressively in the epigastrium 12 hours before admission to the hospital and then it spread to the abdomen, analgezic, not responding to the usual analgesic treatment. The anamnesis showed the patient repeatedly accused pain in the superior abdominal compartment, associated with nausea and vomiting, interpreted as dyspeptic syndrome of (probably) biliary etiology, responsive to the antispastic treatment. Intraoperatively, a diagnostic was established: hemoperitoneum due to the spontaneous rupture of a voluminous tumor (>10 cm), with extraluminal evolution in the gastric fornix and the macroscopic outlook of a GIST. Total gastrectomy is performed, with DII lymph node dissection (lymphadenectomy) and reconstruction of digestive continuity through Roux-en-Y eso-jejunal-anastomosis. The anatomo-pathological exam highlighted a gastrointestinal stromal tumor (GIST), TNM staging: pT4; pN0 (0/17); LV0; Pn0; R0. The patient had a favourable evolution. Since this type of pathology is extremely rare and difficult to diagnose, we believed it would be useful to present and review its micro and macroscopic aspects.

Hemoperitoneum

10.37897/rjmp.2016.3.11

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[Clinical case--voluminous diaphragmatic hernia--surgically acute abdomen: diagnostic and therapeutical challenges].

PubMed (2011)

D. Dumitrescu C Şavlovschi R Borcan H Panţu Dragoș Șerban

We present the case of a 58-year old male patient admitted in the surgery section of the University Emergency Hospital of Bucharest and diagnosed with acute abdomen. The minimal clinical-paraclinical investigation (i.e., thorax-pulmonary Xray, biological probes) raises questions as to the differentiated diagnosis and other associated diseases, also suggesting the existence of voluminous diaphragmatic hernia. The CT thorax-abdomen examination confirms the diaphragmatic hernia suspicion, with intra-thorax ascent of the colon up to the anterior C4 level, but does not explain the abdominal suffering; thus we suspected a biliary ileus or acute appendicitis. Medial laparotomy was imperative. Intrasurgically peritonitis was noticed located by gangrenous acute apendicitis, perforated, with coprolite, for which apendictomy and lavage-drainage pf the peritoneal cavity was performed. Post-surgical status: favourable to recovery.

Thorax (insect anatomy)

Acute abdomen

Ileus

Thoracic cavity

Abdominal cavity

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Citations (14)

Repair of the Orbital Wall Fractures in Rabbit Animal Model Using Nanostructured Hydroxyapatite-Based Implant

Nanomaterials (2016)

S Grădinaru L. M. Popescu Roxana Mioara Piticescu Sabina Zurac Radu Ciuluvică

Cellular uptake and cytotoxicity of nanostructured hydroxyapatite (nanoHAp) are dependent on its physical parameters. Therefore, an understanding of both surface chemistry and morphology of nanoHAp is needed in order to be able to anticipate its in vivo behavior. The aim of this paper is to characterize an engineered nanoHAp in terms of physico-chemical properties, biocompatibility, and its capability to reconstitute the orbital wall fractures in rabbits. NanoHAp was synthesized using a high pressure hydrothermal method and characterized by physico-chemical, structural, morphological, and optical techniques. X-ray diffraction revealed HAp crystallites of 21 nm, while Scanning Electron Microscopy (SEM) images showed spherical shapes of HAp powder. Mean particle size of HAp measured by DLS technique was 146.3 nm. Biocompatibility was estimated by the effect of HAp powder on the adhesion and proliferation of mesenchymal stem cells (MSC) in culture. The results showed that cell proliferation on powder-coated slides was between 73.4% and 98.3% of control cells (cells grown in normal culture conditions). Computed tomography analysis of the preformed nanoHAp implanted in orbital wall fractures, performed at one and two months postoperative, demonstrated the integration of the implants in the bones. In conclusion, our engineered nanoHAp is stable, biocompatible, and may be safely considered for reconstruction of orbital wall fractures.

Biocompatibility

Biocompatible material

10.3390/nano6010011

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Citations (18)

Correlations between eyelid tumors and tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women.

PubMed (2015)

I Careba Andreea Chiva Monica Totir E Ungureanu S Grădinaru

Common ophthalmological problems are found in patients with eyelid tumors and include ocular surface diseases, such as dry eyes, eyelid disorders, excessive tearing and ocular inflammation.The potential correlation between the symptomatology, tear break-up time (TBUT) and lipocalin, lactoferrin and lysozyme concentrations in the tear film were investigated in a group of symptomatic dry-eyed postmenopausal (PM) women compared to age-matched controls, considering the patients with eyelid tumors.66 females were divided into two groups of 33 females each, one group having dry eye (DE) and one asymptomatic group (non-dry eye) (NDE), based on their responses to the OSDI questionnaire, TBUT and Schirmer test evaluation. Tears were collected via capillary tubes. Tear lysozyme, lactoferrin and lipocalin concentrations were determined via electrophoresis and the results for patients with or without eyelid tumors were compared. The results revealed significant differences in lysozyme concentration between patients with or without eyelid tumors in the DE group (p = 0.004). Lower levels for TBUT and lactoferrin in the DE group were also found, compared to the NDE group for eyelid tumors patients. Tear lipocalins were in the same range in both groups.Within a PM population, some components of the tear film were found to be at lower levels in patients with eyelid tumors, compared to patients without this pathology, which resulted in the development of DE or in the enhancement of the symptoms of an existing DE.

Lactoferrin

Xerophthalmia

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Citations (14)

THERAPEUTIC ATTITUDES FOR PANCREATIC PSEUDOCYST

Pancreas (2005)

S Grădinaru S Neagu Radu Costea C Dumitrescu V Badea

Background: The aim of this study is to present our experience concerning pancreatic pseudocyst. Methodology: We reviewed data of 14 patients with pancreatic pseudocyst, which have been admitted in our department from 2001-2004. Results: There were five females with an average age of 53 (range, 37 to 75) and nine males with an average age of 49 (range, 46 to 68). The average duration of interval between the episode of acute pancreatitis and pancreatic pseudocyst diagnosis was 21 days. The diagnosis was established by ultrasound and CT scan. The aetiology of pancreatic pseudocyst was necrotic acute pancreatis (alcoholic in six cases, biliary in two cases and ERCP induced pancreatitis in one case) and alcoholic chronic pancreatitis in one case. In four cases we couldn't identify any previous episode of acute pancreatitis. The management of our patients was surgical approach in ten cases and medical\conservatory approach in four cases. Indications for surgical intervention were: pseudocyst diameter above 5 cm (six cases), abdominal pain (one case) and persistence of pseudocyst more than three months (three cases). During surgery we discovered pancreatic pseudocysts with an average diameter of 8 cm. In two cases were observed two pancreatic pseudocysts. We disposed of two surgical approaches: external drainage (three cases) and enteral drainage (seven cases). The postoperative evolution was favourable for all patients. All patients left the hospital in a good condition. Conclusions: Pancreatic pseudocyst represents a severe complication in evolution of some patients with necrotic acute pancreatitis or chronic pancreatitis. Correct diagnosis and surgical intervention for selected cases are essential steps in management of pancreatic pseudocyst.

Pancreatic pseudocyst

Etiology

Pancreatic Disease

10.1097/01.mpa.0000193672.24772.c9

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[Macular hole--a rare complication of toxocariasis].

PubMed (2007)

Liliana Voinea Elena Podoleanu Daniela Ion S Grădinaru E Ungureanu

Macular hole is a condition that characterizes older patients, being rare in adolescent patients and exceptionally at children. The etiopathogenic mechanism of most macular holes in children and adolescent is idiopathic. The suggested etiopathogenic mechanism is vitreoretinal traction due to a toxocara granuloma for a 9 years old girl.

Girl

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