Hong‐Min Liu

With the expectation to find out novel and effective anti-tumor agents, a series of novel 2,4,6-substituted pyrimidine derivatives were synthesized and evaluated for their anti-tumor activity against four human cancer cells [SW-620 (human colon cancer cells), PC-3 (human prostate cancer cells), A549 (Human non-small cell lung cancer cells), MGC-803 (human gastric cancer cells)] using methyl thiazolyl tetrazolium (MTT) assay.Among tested compounds, N-((4-ethylphenyl)carbamoyl)-2-((4-(p-tolylamino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)acetamide (5i), 2-((4-((4-ethoxyphenyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)-N-((4-ethylphenyl)carbamoyl)acetamide (5o) and N-((4-ethylphenyl)carbamoyl)-2-((4-((4methoxyphenyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)acetamide (5r) displayed strong antiproliferative activity on 4 tested cancer cell lines.In particular, compound 5r has the highest inhibitive activity, and possessed the lowest IC 50 value of

10.6023/cjoc202007067

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Design, synthesis and antitumor activity evaluation of 5-cyano-2,4,6-substituted pyrimidine derivatives containing acrylamide group

Medicinal Chemistry Research (2023)

Fuqiang Yu Lingling Chi Hao Wang Chao Gao Honglin Dai

MTT assay

IC50

10.1007/s00044-023-03099-7

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Citations (2)

Synthesis and Antitumor Activity of Novel 1,3-Disubstituted Pyridazinone Derivatives

Chinese Journal of Organic Chemistry (2020)

Luye Zhang Yang Zhang Chongnan Bao Peng Yang Erdong Li

摘要为了寻找高效低毒的抗肿瘤药物, 设计并合成新型的 1,3 位取代酞嗪酮类化合物.采用噻唑蓝(MTT)法对目标化合物在 MCF-7(人乳腺癌细胞)、PC-3(人前列腺癌细胞)、SW-620(人结肠癌细胞)和 HGC-27(人胃癌细胞)四种人类癌细胞的抗增殖活性进行评价.结果显示大部分化合物具有较好的抗增殖活性.

10.6023/cjoc201908012

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Synthesis and Antitumor Activity of Novel Quinazoline Derivatives Containing Acrylamide

Chinese Journal of Organic Chemistry (2020)

Luye Zhang Yang Zhang Zhengjie Wang Tao Wang Erdong Li

a,b,d ( a 郑州大学药学院郑州 45000) ( b 新药创制与药物安全性评价河南省协同创新中心郑州 450001) ( c 省部共建食管癌防治国家重点实验室郑州 450052) ( d 教育部药物制备关键技术重点实验室郑州 450001) 摘要为了寻找高效低毒的抗肿瘤药物, 设计并合成了一系列新型的含 N-(3-丙烯酰胺苯基)乙酰胺结构的喹唑啉类衍生物, 并采用噻唑蓝(MTT)法测定了目标化合物对 H1975(人肺腺癌细胞系)

Quinazoline

10.6023/cjoc202005081

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Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway

European Journal of Medicinal Chemistry (2020)

Jian Song Qiu-Lei Gao Bowen Wu Ting Zhu Xinxin Cui

Benzothiazole

Hippo signaling pathway

Docking (animal)

10.1016/j.ejmech.2020.112618

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Citations (52)

2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K

European Journal of Medicinal Chemistry (2019)

Er-dong Li Lin Qiao Yaqi Meng Lu-ye Zhang Panpan Song

MTT assay

10.1016/j.ejmech.2019.03.030

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Citations (23)

Studies on the Novel α-Glucosidase Inhibitory Activity and Structure—Activity Relationships for Andrographolide Analogues.

ChemInform (2006)

Gui‐Fu Dai Haiwei Xu Junfeng Wang Feng‐Wu Liu Hong‐Min Liu

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Andrographolide

10.1002/chin.200633197

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CCDC 628469: Experimental Crystal Structure Determination

The Cambridge Structural Database (2007)

Lin Yan Gui‐Fu Dai Jian-Li Yang Feng‐Wu Liu Hong‐Min Liu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccp2z6x

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Hong‐Min Liu

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