Tadaki Yasumura

Kyoto Prefectural University of Medicine

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Takahiro Oka

Kindai University

I Aikawa

Kyoto Prefectural University of Medicine

Ichiro Nakai

Kyoto Medical Center

Yoshihiro Ohmori

Meikai University

Norio Yoshimura

Kyoto Prefectural University of Medicine

Yoshihiro Nakane

Japan Proton Accelerator Research Complex

Kanji Takada

Kyoto Pharmaceutical University

T Hamashima

Kyoto first Red Cross hospital

Nobuyuki Sugioka

Kobe Gakuin University

Takashi Hamajima

Japan Pediatric Society

Cooperative Institutions

Kyoto Prefectural University of Medicine

Kyoto University

University Hospital Kyoto Prefectural University of Medicine

Osaka University

Shiga University of Medical Science

Kyoto Pharmaceutical University

Kyoto City Hospital

The University of Tokyo

Kyoto first Red Cross hospital

Tohoku University

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Effect of Cyclosporine on the Endocrine and Exocrine Pancreas in Kidney Transplant Recipients

American Journal of Kidney Diseases (1988)

Norio Yoshimura Ichiro Nakai Yoshihiro Ohmori I Aikawa Masatake Fukuda

Prednisolone

10.1016/s0272-6386(88)80065-9

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Citations (80)

Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension

Hypertension Research (1995)

Manabu Yoshimura Toshiaki Komori Masato Nishimura Yoshizumi Habuchi Naohisa Fujita

10.1291/hypres.18.supplementi_s87

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Citations (10)

Renal transplantation for patients with long-term hemodialysis.

Nihon Toseki Igakkai Zasshi (1996)

Norio Yoshimura Takahiro Oka Yoshihiro Ohmori Tadaki Yasumura Ichiro Nakai

血液浄化法の進歩は透析患者の長期生存を可能にし, このような患者に対する腎移植の機会も増えてきている. 今回10年以上の透析歴を有する患者に対する腎移植について検討した. シクロスポリン (CsA) 導入 (昭和57年4月) 以降の腎移植症例は258例であり, このうち17例が10年以上の透析歴を有していた. 5例が死体腎, 12例が生体腎移植を受けていた. 移植前に腎以外の病変を合併していた症例は手根管症候群1例, 二次性副甲状腺機能亢進症による副甲状腺摘出2例, 無腐性骨壊死1例, 神経因性膀胱1例, 肝炎6例であった. 移植後1年, 3年の生着率はそれぞれ73%, 73%であった. 合併症として糖尿病2例, 肝障害2例, 膵炎1例, 消化管出血1例であったが長期透析が原因で移植腎を失った症例はなかった. 長期透析患者は種々の合併症を有するが良好な移植成績とQOLの向上が得られる.

10.4009/jsdt.29.359

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EFFECT OF ADJUVANT ENDOCRINOCHEMOTHERAPY ON OVARIAN FUNCTION IN PREMENOPAUSAL PATIENTS AFTER RADICAL MEASTECTOMY

The journal of the Japanese Practical Surgeon Society (1989)

Tadaki Yasumura I Aikawa Kohei Arakawa Norio Yoshimura Chol Ju LEE

Influence of adjuvant endocrinochemotherapy on the ovarian and pituitary functions was studied in 30 premenopausal patients after radical mastectomy. Of these patients 16 (53.3%) became amenorrheic after treatment. Severe amemorrhea lasting over one year developed in 4 patients treated with cyclophosphamide (CY) in combination with tegafur with or without tamoxifen (TAM). These patients showed significantly lower levels of estradiol 17-β(E2) and progesterone accompanying with increased levels of gonadotropins than the others with amenorrhea. This endocrine status and amenorrhea continued after cessation of CY administration. Amenorrhea also developed in 11 of 23 patients (47.8%) treated with TAM and tegafur. Although the level of E2 measured in patients with amenorrhea remained within a range of healthy women, it was significantly higher in patients without amenorrhea. After cessation of TAM and tegafur administration, regular menstruation recovered in patients with amenorrhea and the high level of E2 decreased to a normal range in patients without amenorrhea. These results suggest that the use of CY as an adjuvant therapy may be favorable in a patients with advanced breast cancer, because CY induces permanent ovarian failure and that tamoxifen which causes a high level of E2 should be carefully given monitoring endocrine status of the patients.

10.3919/ringe1963.50.1264

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SEVEN CASES OF OCCULT TO HREAST CANCER

The journal of the Japanese Practical Surgeon Society (1990)

Takashi Hayashi Tadaki Yasumura Takahiro Oka

Clinical history, diagnostic procedure and histopathological findings were reviewed in 7 patients with occult breast cancer. Chief complaints were bloody discharge from the nipple in 4 and mastodynia in 2 patients. One patient visited our clinic for the purpose of screening for breast cancer. Among 4 patients with nipple discharge, final diagnosis was established throgh microdochectomy coupled with contrast mammography in 2, and by histopathological examination of a small tissue accidentally pushed out from the nipple during the procedure of contrast mammography in one. The remaining patient underwent no biopsy, not only because the discharge was positive for malignant cells but also her mammography disclosed a cluster of microcalcification. In other 3 patients without nipple discharge, their mammogram showed a cluster of microcalcification and histopathological diagnosis was achieved by excisional biopsy of the breast containing the area with microcalcification. From histopathological findings that all 3 cases discovered by microcalcification alone were noninvasive while 3 of 4 with nipple discharge invasive, occult breast cancer discovered by microcalcification in mammorgram alone seems to be earlier in stage than that discovered by nipple discharge.

Microcalcification

Nipple discharge

Occult

Histopathological examination

10.3919/ringe1963.51.478

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In vivo and in vitro effects of the antifungal agent miconazole on estrogen biosynthesis in human breast cancer

European Journal of Cancer and Clinical Oncology (1989)

Takara Yamamoto Masaaki Fukuoka Tadaki Yasumura Hiroji Okada

10.1016/0277-5379(89)90110-7

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Citations (4)

The effect of cyclosporine on mortality and renal function in living related pediatric kidney transplant recipients

The Japanese Journal of Surgery (1988)

N Yoshimura Takahiro Oka Yoshihiro Ohmori I Aikawa Masatake Fukuda

Nephrotoxicity

Immunosuppression

Acute tubular necrosis

Prednisolone

10.1007/bf02471429

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Citations (1)

Determination of a new immunosuppressant, mycophenolate mofetil, and its active metabolite, mycophenolic acid, in rat and human body fluids by high-performance liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications (1994)

Nobuyuki Sugioka Hikaru Odani Toshio Ohta Hideki Kishimoto Tadaki Yasumura

Mycophenolate

Active metabolite

10.1016/0378-4347(94)00006-9

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Citations (57)

Estrone sulfate and sulfatase activity in human breast cancer and endometrial cancer

Journal of Steroid Biochemistry (1989)

Kazuo Naitoh Hideo Honjo Takara Yamamoto Mamoru Urabe Yoshio Ogino

Estrone sulfate

Sulfatase

10.1016/0022-4731(89)90408-1

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Citations (71)

A CASE OF SUCCESSFUL RENAL AUTOTRANSPLANTATION FOR RENOVASCULAR HYPERTENSION WITH RENAL DYSFUNCTION

The journal of the Japanese Practical Surgeon Society (1989)

Yasunori Sawabe Norio Yoshimura I Aikawa Tadaki Yasumura Takayuki Yoshida

A case of renovascular hypertension in a 46 year-old male was reported. He showed a gradually advancing renal dysfunction with hypertension which was uncontrolable by any antihypertensive drugs. Renal angiography showed that the left kidney was hypoplastic and that severe stenosis existed in the right renal artery. Autotransplantation of the right kidney with simultaneous left nephrectomy was performed. After operation, the blood pressure and the renal function were improved remarkably without any complications.

Renovascular Hypertension

Autotransplantation

10.3919/ringe1963.50.1222

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