M. Koot

Radboud University Nijmegen

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Hans L. Zaaijer

Sanquin

M Tersmette

St. Antonius Ziekenhuis

Ireneus P.M. Keet

GGZ Noord-Holland-Noord

Frank Miedema

University Medical Center Utrecht

Frank Miedema

Utrecht University

R A Coutinho

University Medical Center Utrecht

M. T. L. Roos

Dutch Blood Transfusion Society

Hanneke Schuitemaker

Janssen (Netherlands)

A. de Niet

Amsterdam University Medical Centers

P T Schellekens

University of Amsterdam

Cooperative Institutions

University of Amsterdam

Academic Medical Center

Dutch Blood Transfusion Society

Amsterdam University Medical Centers

Public Health Service of Amsterdam

Sanquin

National Institute for Public Health and the Environment

Utrecht University

Radboud University Nijmegen

Erasmus University Rotterdam

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753 BASELINE HBsAg PREDICTS HBsAg LOSS AFTER 2 YEARS OF TREATMENT-FREE FOLLOW-UP IN CHRONIC HEPATITIS B PATIENTS TREATED WITH PEGINTERFERON alfa-2a AND ADEFOVIR

Journal of Hepatology (2013)

L. Jansen R. Bart Takkenberg A. de Niet Hans L. Zaaijer Christine J. Weegink

Adefovir

Peginterferon alfa-2a

10.1016/s0168-8278(13)60755-2

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Citations (3)

Prospective Longitudinal Analysis of Viral Load and Surrogate Markers in Relation to Clinical Progression in HIV Type 1-Infected Persons

AIDS Research and Human Retroviruses (1997)

Sylvia M. Bruisten P. H. J. Frissen Peter van Swieten P. Richard Harrigan I. Kinghorn

The temporal relationship between viral and surrogate markers and clinical status was analyzed prospectively every 8 weeks in 34 asymptomatic HIV-1-infected persons. After 3 years, 25 persons remained clinically healthy whereas 9 persons showed clinical progression. In accordance with other reports we found that at study entry HIV-RNA load was predictive of clinical progression. All markers tested evolved significantly in time in both progressors and nonprogressors. The HIV RNA load in plasma and HIV DNA load in T cells were linearly related only in nonprogressors. In addition, the RNA/DNA ratio during follow-up was significantly higher in progressors, indicating a higher replication rate in progressors. The HIV DNA load correlated inversely with CD4+ T cell counts and positively with p24 antigenemia in both nonprogressors and progressors. A significant correlation of HIV DNA load with SI phenotype occurred in progressors only. HIV RNA levels correlated with β2-microglobulin level and with p24 antigenemia but not with SI phenotype. These three markers can all routinely be measured in plasma; however, only the HIV RNA levels appear to be informative for clinical progression. Six to 8 months before clinical progression, an SI phenotype switch, increased HIV RNA in plasma, and decreased CD4+ T cell counts were all indicative of an impending clinical event.

Asymptomatic carrier

Surrogate endpoint

10.1089/aid.1997.13.327

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Citations (27)

Immunological reconstitution after triple combination therapy in HIV-1 infection

Immunology Letters (1997)

Nadine G. Pakker Daan W. Notermans Frank Miedema Rob J. de Boer Marijke Roos

10.1016/s0165-2478(97)85093-6

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Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers

Journal of Viral Hepatitis (2002)

Hans L. Zaaijer P.N. Lelie Christina M. J. E. Vandenbroucke‐Grauls M. Koot

Among 1081 persons testing positive for hepatitis B surface antigen, 106 (10%) tested positive for antibodies to surface antigen (anti-HBs) in the same blood sample. Thirty of these persons were studied in detail: seven tested positive for hepatitis B e-antigen, nine were apparently healthy blood donors, and in 14 chronic infection could be demonstrated in follow-up samples. Frozen samples of 14 persons were available for additional quantitative anti-HBs testing using another anti-HBs assay: three showed no anti-HBs reactivity, seven showed borderline anti-HBs levels (1-5 IU/L), and anti-HBs titres ranged from 23 to 66 IU/L in four HBsAg-positive persons, including an apparently healthy blood donor. Thus, after hepatitis B vaccination of medical personnel, presence of anti-HBs may erroneously suggest immunity, while in fact chronic infection with hepatitis B virus is present.

Hepatitis B

10.1046/j.1365-2893.2002.00342.x

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Citations (9)

A case of strongyloides hyperinfection during corticosterold treatment

European Journal of Gastroenterology & Hepatology (1999)

M. Koot A.P. Rietveld Jacques M.G.W. Wouters A. J.P. van Tilburg

Koot, M. M.; Rietveld, A. P.; Wouters, J. M.G.W.; van Tilburg, A. J.P. Author Information

Strongyloides

Strongyloides stercoralis

10.1097/00042737-199912000-00158

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Citations (0)

Two Domains within the Early Coding Region of SV40 Involved in the Transformation of Human Fibroblasts

Intervirology (1987)

Anthony de Ronde C. J. A. Sol Marcy E. MacDonald M. Koot Jan ter Schegget

The early gene products of simian virus 40 (SV40) transform human fibroblasts, whereas those of the human papovavirus BK(BKV) do not. The early gene products of both SV40 and BKV transform baby rat kidney cells. SV40-BKV chimerics were constructed which were able to transform baby rat kidney cells. Using the SV40-BKV chimerics, two domains within the SV40 large T protein were identified which are involved in the transformation of human fibroblasts.

Papovavirus

Simian

Coding region

Human kidney

10.1159/000150019

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Citations (2)

Frequent hepatitis E in the Netherlands without traveling or immunosuppression

Journal of Clinical Virology (2014)

Hans M. Koot Boris M. Hogema M. Koot Michel Molier Hans L. Zaaijer

Hepatitis E Virus

Hepatitis E

Immunosuppression

Viral Hepatitis

Hepatitis C

10.1016/j.jcv.2014.11.020

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Citations (34)

The Mirizzi syndrome

European Journal of Gastroenterology & Hepatology (1999)

M. Koot A. J.P. van Tilburg H. S. L. M. Tjen M. van Blankenstein

Koot, M. M.; van Tilburg, A. J.P.; Tjen, H. S.L.M.; van Blankenstein, M. Author Information

10.1097/00042737-199912000-00159

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Immunologic and virologic markers determining progression to AIDS.

PubMed (1995)

P T Schellekens M. Koot M. T. L. Roos M Tersmette Frank Miedema

Infection with the human immunodeficiency virus type 1 (HIV-1) results in a severe immunodeficiency characterized by a depletion of CD4+ T-helper cells. Furthermore, it is well documented that in asymptomatic persons the number of CD4+ cells is also a good predictor of progression to AIDS. However, persons with similar CD4+ cell counts may differ with regard to clinical progression. For this reason the development of additional markers predictive of disease progression is of major clinical importance. In this review three additional progression markers are discussed: rate of decline of CD4+ cells, T-cell reactivity, and HIV biological phenotype. Besides their usefulness as independent progression markers they also provided insight into immunopathologic mechanisms responsible for the eventual development of AIDS.

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Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir

Scandinavian Journal of Gastroenterology (2012)

A. de Niet R. Bart Takkenberg Ryma Benayed Bridget Riley‐Gillis Christine J. Weegink

In a cohort of 95 chronic hepatitis B patients, who were treated with peg-interferon and adefovir for 1 year, and who had 15% HBsAg loss (overall), no association was found between IL28B polymorphisms and HBeAg seroconversion or HBsAg clearance. These findings suggest that any association with outcome, if present, is less than that seen in chronic hepatitis C. Additional studies are needed to enlarge sample size and to refine our understanding of IL28B biology in the context of chronic hepatitis B response to immunomodulatory and direct antiviral therapy.

Adefovir

Seroconversion

Pegylated interferon

HBeAg

10.3109/00365521.2011.648952

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Citations (31)