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A. Skalli

Mohammed V University

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N. Çhikhaoui

University of Hassan II Casablanca

F. El Amraoui

Institut Agronomique et Vétérinaire Hassan II

Naïma Bouslam

Mohammed V University

O. Kacimi

Centre Hospitalier Universitaire Ibn Rochd

A. Ouchen

Association Marocaine Pour la Recherche Développement

Ahmed Bouhouche

Mohammed V University

Ali Benomar

Mohammed V University

Houyam Tibar

Centre Hospitalier Ibn Sina

A. Ratsimbazafy

Centre Hospitalier de Béthune

Nadia Moussali

University of Hassan II Casablanca

Cooperative Institutions

Association Marocaine Pour la Recherche Développement

Centre Hospitalier Universitaire Ibn Rochd

Mohammed V University

Hôpital 20 Août

University of Hassan II Casablanca

Centre Hospitalier Ibn Sina

Inserm

Centre Hospitalier de Béthune

Hôpital d'Enfants

Assistance Publique – Hôpitaux de Paris

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Association of vitamin D status with multiple sclerosis in a case-control study from Morocco

Revue Neurologique (2018)

A. Skalli El Hachmia Ait Ben Haddou Rachid El Jaoudi Rachid Razıne Ghislain Armel Mpandzou

Hypovitaminosis

10.1016/j.neurol.2017.06.030

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Citations (19)

Impotence fonctionnelle de la hanche gauche

Feuillets de Radiologie (2012)

Dalal Laoudiyi A. Skalli N. Çhikhaoui

10.1016/j.frad.2012.02.002

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DIV-WS-10 Apport de l’imagerie dans les tumeurs glomiques des extremites digitales

Journal de Radiologie (2007)

E. El Ouardi D. Basraoui A. Skalli F. El Amraoui A. Menfaa

10.1016/s0221-0363(07)81750-1

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CV42 Traumatisme des gros vaisseaux : apport de l’imagerie. A propos de deux cas

Journal de Radiologie (2005)

A. Ouchen Nadia Moussali T. Elmendili F. El Amraoui A. Skalli

10.1016/s0221-0363(05)75953-9

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LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease

Parkinson s Disease (2017)

Ahmed Bouhouche Houyam Tibar Rafiqua Ben El Haj Khalil El Bayad Rachid Razıne

Background . The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson’s disease (PD) identified to date. This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population. In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson’s disease. Methods . 100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia. The LRRK2 G2019S mutation was investigated by direct sequencing in patients and ethnically matched controls, all of Moroccan origin. Results. Among the 100 PD Moroccan patients, 41 (41%) were carriers of the G2019S mutation. The mutation frequency was higher among probands with autosomal dominant inheritance (76%) than among sporadic ones (28%). Interestingly, G2019S mutation was also found in 5% of control individuals. Clinically, patients carrying the G2019S mutation have more dystonia (OR = 4.6, p = 0.042) and more sleep disorders (OR = 2.4, p = 0.045) than noncarriers. Conclusions. The LRRK2 G2019S prevalence in Morocco is the highest in the world reported to date. Some clinical features in G2019S carriers such as dystonia and sleep disturbances are worth noting.

LRRK2

Proband

10.1155/2017/2412486

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Citations (45)

Kyste hydatique cardiaque

La Presse Médicale (2004)

Z. Jouhadi Fatima Ailal N. Dreoua A. Zine Eddine A. Abid

Hydatid cyst

10.1016/s0755-4982(04)98902-6

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Tentative d’autolyse compliquée d’une pneumopathie d’inhalation révélant… une légionellose. Apport de l’antigène légionelle urinaire dans le diagnostic

Immuno-analyse & Biologie Spécialisée (2012)

S. Nguyen S. Dekeyser E. Beclin A. Ratsimbazafy A. Skalli

Amoxicillin/clavulanic acid

10.1016/j.immbio.2012.02.007

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CV39 Manifestation exceptionnelle de la maladie de Behçet : fibrose endomyocardique

Journal de Radiologie (2005)

Nadia Moussali A. Ouchen T. Elmendili F. El Amraoui A. Skalli

10.1016/s0221-0363(05)75950-3

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Iconography : Kyste hydatique du médiastin. À propos de 2 cas

A. Skalli F. El Amraoui N. Çhikhaoui R Kadiri

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US-WS-12 Une cause rare d’insuffisance veineuse des membres inferieurs : syndrome de kuppel-trenaunay

Journal de Radiologie (2007)

O. Kacimi J. Bensalah A. Skalli F. El Amraoui N. Çhikhaoui

10.1016/s0221-0363(07)82066-x

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