M Nafeh

Assiut University

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Ahmed Medhat

National Institute of Standards

G. Thomas Strickland

University of Maryland, Baltimore

Nabiel Mikhail

Assiut University

Mohamed Shehata

Cairo University

Mohamed Tarek M. Shata

University of Cincinnati Medical Center

Alan Fix

Program for Appropriate Technology in Health

A Helmy

Institute of Electrical and Electronics Engineers

Mohamed Abdel-Hamid

Al-Azhar University

Michael Oellerich

University of Göttingen

Enas Daef

Assiut University

Cooperative Institutions

Assiut University

Ain Shams University

University of Maryland, Baltimore

Case Western Reserve University

Hy-Line (United States)

RELX Group (Netherlands)

Cairo University

Harvard University

Aichi Cancer Center

The Japanese Society of Gastroenterological Surgery

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Risk factors and immune response to hepatitis E viral infection among acute hepatitis patients in Assiut, Egypt.

PubMed (2010)

Salwa Seif Eldin Ismail Seddik Enas Daef Mohamed Tarek M. Shata Marwa M. Raafat

Hepatitis E virus (HEV) infection is a common cause of acute viral hepatitis (AVH) in Egypt. We aimed to identify risk factors of HEV among acute hepatitis cases, measure HEV specific immune response to differentiate between symptomatic and asymptomatic infections. The study included symptomatic acute hepatitis (AH) patients (n = 235) and asymptomatic contacts (n = 200) to HEV cases. They completed a lifestyle questionnaire, screened for common hepatotropic viruses. Blood and serum samples were collected from patients and contacts after onset of disease and follow-up samples collected until convalescence. PBMC were separated and tested for specific HEV T-cell response by INF-gamma ELISPOT assay. Serum samples were tested for IgM and IgG anti-hepatitis E virus by ELISA. IgM antibodies to HAV were detected in 19 patients (8.1%), 37 (15.7%) with HBV, 10 (4.3%) with HCV. HEV infection was identified in 42 (16%) patients with AVH. Of the 200 contacts, 14 (7%) had serological evidence of recent HEV asymptomatic infection, showed stronger CMI responses than HEV infected subjects (2540 +/- 28 and 182 +/- 389 ISCs/106 cells, respectively; P < 0.05). In conclusion, HEV is a major cause of AVH in Egypt. Asymptomatic HEV patients are likely to have stronger immune responses including CMI responses, than symptomatic cases.

Hepatitis E Virus

Convalescence

Hepatitis E

Viral Hepatitis

ELISPOT

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Citations (16)

Assessment of liver function by the MEGX test in patients with schistosomiasis and cirrhosis

Clinical Biochemistry (1999)

Ehab S. EL Desoky Ahlam M Ahmed M Nafeh Hanan Abd El-Aty Ahmed Ekkehard Schütz

Liver function

10.1016/s0009-9120(99)00007-7

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Citations (2)

Evaluation of an Ultrasonographic Score for Urinary Bladder Morbidity in Schistosoma haematobium Infection

American Journal of Tropical Medicine and Hygiene (1997)

Ahmed Medhat Abdalrahman Zarzour M Nafeh Mohamed Tarek M. Shata Y. Sweifie

An ultrasonographic urinary bladder morbidity score was developed and tested in 510 patients with schistosomiasis haematobia, and then evaluated for screening 1,134 randomly selected children from villages endemic for Schistosoma haematobium. The ultrasonographic urinary bladder morbidity score had four grades ranging from normal to marked thickening of the urinary bladder wall or any polyps or masses. Among both patients and randomly screened subjects, the ultrasonographic score was greater (P = 0.01 and P < 0.01) in males than in females. Children examined in the clinic had higher (P = 0.03) ultrasonographic scores than adults. Infected subjects in communities were more likely (P < 0.001) to have urinary bladder morbidity than uninfected subjects, and clinic patients with egg counts > or = 20 eggs/10 ml of urine had higher (P = 0.03) ultrasonographic urinary bladder morbidity scores than those with lighter infections. The geometric mean egg count was higher (P = 0.04) in clinic patients with grade II and III lesions than in those with grade 0 and I lesions. There was progressive improvement of the grade of urinary bladder morbidity scores in patients treated with praziquantel at each follow-up examination (P < 0.001) and there was a positive relationship (P < 0.01) between urinary bladder morbidity scores and ultrasonographic-detected renal back pressure changes. The ultrasonographic urinary bladder morbidity score objectively measured the severity of urinary bladder morbidity and correlated with intensity of S. haematobium infection in our subjects. It can be used in evaluating both morbidity in patients and in community surveys and in following the outcome of chemotherapy.

10.4269/ajtmh.1997.57.16

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Citations (23)

Contents

Gastrointestinal Endoscopy (2010)

Georg R. Linke Andreas Zerz Florian Kapitza René Warschkow Jessica Lange

10.1016/s0016-5107(10)01433-1

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Hepatitis C in a community in Upper Egypt: I. Cross-sectional survey.

American Journal of Tropical Medicine and Hygiene (2000)

M Nafeh Ahmed Medhat Mohamed Shehata Nabiel Mikhail YoussefM Swifee

The prevalence of antibody to hepatitis C virus (anti-HCV) was determined in a cross-sectional survey in a village in Upper Egypt. Exposure and demographic characteristics were obtained through a questionnaire. Antibody to hepatitis C virus was assessed using a second generation enzyme immunoassay, and the presence of HCV RNA was tested using a reverse transcriptase-polymerase chain reaction. Collection of blood samples was targeted at those > or = 5 years old, and obtained from 62.8%. This report describes the community, the HCV infection characteristics of the subjects, and evaluates some factors associated with presence of anti-HCV. Of the 6,031 participants, 522 (8.7%) were anti-HCV positive. Prevalence was higher among males than females (11.3% versus 6.5%; P < 0.001). It was greater among those > 30 years of age than among those < or = 30 years of age (20.0% versus 3.6%; P < 0.001). Those who were less educated, farmed, provided health care, and were currently married had a significantly higher anti-HCV prevalence than those who were not; however, these associations were not significant after adjusting for age. Although active infections with Schistosoma haematobium were not associated with anti-HCV, a history of past infection was (age-adjusted risk ratio [RR] = 2.1, 95% confidence interval [CI] = 1.8, 2.4); 134 persons who had a history of receiving parenteral anti-schistosomal therapy had a higher age-adjusted RR (3.0; 95% CI = 2.5, 3.7) for anti-HCV than those who did not. Hepatitis C virus RNA was detected in 62.8% of the anti-HCV positive subjects, without significant variation by age, gender, education, or marital status. The prevalence of anti-HCV in Upper Egypt is high, albeit lower than in Lower Egypt, with continuing but limited transmission indicated by the lower prevalence in residents < or = 30 years old.

Cross-sectional study

10.4269/ajtmh.2000.63.236

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Citations (109)

Ultrasound-detected hepatic periportal thickening in patients with prolonged pyrexia.

American Journal of Tropical Medicine and Hygiene (1998)

Ahmed Medhat M Nafeh YoussefM Swifee A Helmy Saad Zaki

Hepatic periportal thickening (HPT) detected by ultrasonography has been established as a reliable tool for measuring hepatic morbidity due to schistosomiasis. During ultrasonographic examination of patients with prolonged pyrexia, we frequently noticed minimal grades of HPT in patients without a history of schistosomiasis. This led to ultrasonographic studies of conditions other than schistosomiasis in which HPT may occur. Subjects included 460 patients with Schistosoma haematobium infection, 107 urban patients with prolonged pyrexia without previous exposure to schistosomiasis, and 288 healthy controls unexposed to schistosomiasis. Grade I HPT was more prevalent (P < 0.001) in patients with pyrexia (56.1%) than in those with S. haematobium (32.2%) and was more frequent (P < 0.001) in patients with S. haematobium than in controls (11.1%). Typhoid fever was the most common febrile illness causing HPT. Grade II lesions were rare in patients with pyrexia (2.8%) or schistosomiasis (0.9%). Grade III lesions were present in only one patient with S. haematobium. Mild grades of HPT can occur in infectious diseases other than schistosomiasis. Cellular infiltration in the portal tract from chronic infectious diseases can frequently give the ultrasonographic appearance of grade I HPT.

10.4269/ajtmh.1998.59.45

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Citations (14)

Safety and Efficacy of Coronary Artery Bypass Grafting Using Bilateral Internal Mammary Arteries Comparing Sequential and Non-Sequential Techniques in Distal Anastomosis

Journal of Cardiovascular Disease Research (2020)

Walaa Ahmed Saber Ahmed H Omar Walid Ismail Kamel Moustafa Gamal El-din Moustafa M Nafeh

Background: This study aimed to shed light on the use of bilateral internal mammary arteries (BIMAs) which is useful in patients undergoing coronary artery bypass grafting. To this end, free IMA grafts allowed to be used for their benefit in total cardiomyopathy in the patients chosen in this study. Aim of the work: This study aims to determine safety and efficacy bilateral Sequentially and composite internal mammary that used for grafting of multiple coronary branches in comparison with bilateral non sequential internal mammary artery by assessment of hospital mortality, early clinical outcomes and postoperative complication. Subjects and methods: The sample chosen in this study consisted of 100 patients who were prepared for onpump CABG for multi-vessel coronary artery disease, classified into two groups fifty cases on each group (sequential and non- sequential). Results: In this study, it was found that there are more coronary targets capable of revascularized with inward mammary artery using sequential technique compared to non-sequential one (p-value= 0.004 S). Conclusion: Sequential technique is better than non-sequential one in achievement total and left system arterial revascularization with less leg incisions.

Mammary artery

Coronary arteries

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Tuberculous Peritonitis in Egypt: The Value of Laparoscopy in Diagnosis

American Journal of Tropical Medicine and Hygiene (1992)

M Nafeh Ahmed Medhat Ahmed Abdulhameed Yasir Ahmad Nabila M Rashwan

Abdominal laparoscopy was performed on 200 patients with undiagnosed ascites. It was unsuccessful in one patient with tuberculous peritonitis because of extensive adhesions. A presumptive diagnosis of tuberculous peritonitis based on clinical findings and peritoneal tubercles or adhesions visualized during laparoscopy was made in 90 of these patients. The diagnosis was confirmed in 88 by histopathology, bacteriology, or therapeutic response. Two of the 109 remaining patients who had other presumptive diagnoses made during laparoscopy were eventually confirmed to be cases of tuberculous peritonitis. Of 91 patients with tuberculous peritonitis included in this series, 79% were females, with the majority (79%) of them being of child-bearing age. Half had been ill for longer than one month. The most frequent complaints were abdominal pain, fever, anorexia, night sweats, abdominal swelling, and weight loss. Ascites, fever, wasting, pallor, and abdominal tenderness were common findings. Ultrasonography demonstrated ascites in all patients who underwent this procedure; 21% also had adhesions. Pleural effusion was present in 15% and pulmonary tuberculosis was detected in only two patients. Biopsy samples taken during laparoscopy showed that 60% had noncaseous granulomas and 33% had caseous granulomas. Mycobacterium tuberculosis was detected in 77%, with guinea pig inoculation having the highest sensitivity, followed by culture, and lastly by acid-fast smear. Mycobacterium tuberculosis was isolated more easily from biopsy samples than from ascitic fluid. Nine of 20 M. tuberculosis isolates that were identified as to species were M. bovis. Tuberculous peritonitis, a frequent cause of febrile ascites in Egyptian women, was easily diagnosed by histopathologic and bacteriologic studies of biopsy samples taken at laparoscopy. All patients responded rapidly to antituberculosis therapy.

Abdominal ultrasonography

Histopathology

Peritoneal fluid

10.4269/ajtmh.1992.47.470

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Citations (58)

Ultrasonographic Changes of the Liver in Schistosoma Haematobium Infection

American Journal of Tropical Medicine and Hygiene (1992)

M Nafeh Ahmed Medhat Youssef Swifae Farag M. Moftah Ahlam Mohamed

Abdominal ultrasonographic examination was performed in 61 hospitalized patients with chronic liver diseases and 253 school children from a village endemic for Schistosoma haematobium and were compared with 142 urban children without exposure to Schistosoma. The prevalence of ultrasound-detectable hepatomegaly and splenomegaly and the degree of periportal fibrosis was compared between those with and without S. haematobium infection. Among 13 patients with biopsy-proven schistosomal hepatic fibrosis, three with coarse changes secondary to S. mansoni infection showed grade III periportal fibrosis, while 10 patients with fine schistosomal hepatic fibrosis due to S. haematobium had borderline (two) or grade I (eight) changes. Ultrasound evidence of periportal fibrosis was not detected in patients with hepatic cirrhosis, chronic active hepatitis, or fatty infiltration. However, three of 14 patients with chronic persistent hepatitis had grade I periportal fibrosis and two had borderline changes. The frequency of ultrasound-detected hepatomegaly and splenomegaly was greater among rural S. haematobium-infected children (35.2% and 22.4%, respectively) than among noninfected rural (21.1% and 13.3%) and urban (16.9% and 4.9%) children. Also, the frequency of grade I periportal fibrosis was significantly greater (P (0.01) in S. haematobium-infected children (22.4%) than in noninfected rural (11.7%) and urban (0.7%) children. No patients with S. haematobium infections, either in the hospital or the village, had grade II or III periportal fibrosis. We conclude that infection with S. haematobium frequently causes mild degrees of periportal fibrosis from schistosomal hepatic fibrosis in the Assiut area, as well as hepatomegaly and splenomegaly, as evidenced by both ultrasound and by histopathologic examination, and that these milder ultrasonographic changes of periportal fibrosis can also have other etiologies, e.g., chronic hepatitis.

Hepatic fibrosis

10.4269/ajtmh.1992.47.225

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Citations (23)

Early Effect of Maximal Utilization of Internal Mammary Arteries on Kidney Function in the Egypt

Indian Journal of Public Health Research & Development (2019)

M Nafeh Kh. Mortada Ahmed M. Sayed

Mammary artery

10.5958/0976-5506.2019.04105.6

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Citations (0)