Israel Parra Ortega

Hospital Infantil de México Federico Gómez

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Briceida López Martínez

Hospital Infantil de México Federico Gómez

R. Ariel Gómez

University of Virginia

Eliseo Ruiz Bedolla

Hospital Infantil de México Federico Gómez

Vanesa Jonguitud Díaz

Margarita Martínez Arias

Mexican Social Security Institute

Guillermo Ruiz Argüelles

Universidad Autónoma de Zacatecas "Francisco García Salinas"

C Sosa

Hôpital d'Hautepierre

Marcela Salazar García

Hospital Infantil de México Federico Gómez

Héctor García Alcalá

European Atherosclerosis Society

Rafael Acuña Prats

Hospital Angeles Clinica Londres

Cooperative Institutions

Universitat Autònoma de Barcelona

Hospital Infantil de México Federico Gómez

Instituto de Salud Carlos III

Vall d'Hebron Hospital Universitari

Centro de Investigación Biomédica en Red

Vall d'Hebron Institut de Recerca

University of Girona

Institut d'Investigació Biomèdica de Girona

Hospital Universitari de Girona Doctor Josep Trueta

Universitat de Barcelona

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Síndrome de las plaquetas pegajosas, la condición de trombofilia heredada más frecuente en pacientes mexicanos

Medicina Universitaria (2007)

Israel Parra Ortega R. Ariel Gómez Guillermo José Ruiz Argüelles

Pathogenesis

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El laboratorio en el diagnóstico de las alteraciones congénitas de las plaquetas: síndrome de Bernard-Soulier

Medicina Universitaria (2006)

Israel Parra Ortega

Bernard–Soulier syndrome

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Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients

PLoS ONE (2018)

Mónica Coll Carles Ferrer‐Costa Sara Pich Catarina Allegue Emilio Rodrigo

Background Patients with end-stage renal disease have very high mortality. In individuals on hemodialysis, cardiovascular deaths account for ~50% of all deaths in this population, mostly due to arrhythmia. To determine the causes of these arrhythmic deaths is essential in order to adopt preventive strategies. The main objective of this study was to investigate whether, the presence of QTc interval alterations, from electrolyte abnormalities or presence of rare genetic variants, could have a relationship with sudden arrhythmogenic deaths in end-stage renal disease patients. Methods We recorded the pre- and post-dialysis QTc interval in 111 patients undergoing hemodialysis. In 47 of them, we analyzed 24 SCD-related genes including the most prevalent genes associated with long QT syndrome using a custom resequencing panel. Results We found a positive although not significant association between the presence of long QTc and mortality in a subset of end-stage renal disease patients. In addition, in five patients with long QTc only after dialysis (21.7%) we detected rare potentially pathogenic genetic variants. Three out of these five carriers subsequently died suddenly. Conclusions Genetic background may be determinant in the risk of sudden cardiac death in these patients. We recommend evaluating the QTc interval before and after hemodialysis, and performing a genetic analysis of individuals with long QTc after hemodialysis.

Sudden Death

10.1371/journal.pone.0200756

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Diagnóstico y características del síndrome de plaquetas pegajosas

Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio (2016)

Israel Parra Ortega Margarita Martínez Arias Briceida López Martínez

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Obstrucción intestinal por divertículo de Meckel y malrotación de colon. Descripción de un caso Intestinal obstruction due to Meckel's diverticulitis and misrotation of the colon. Description of one case

Rafael Acuña Prats Mauricio Madera Israel Parra Ortega C Sosa

Objective: To describe the case of a patient with an intestinal obstruction secondary to a volvulus of the small intestine due to a Meckel’s diveritculum and misrotation of the colon. Setting: Second level health care hospital. Description of the case: A 22 years old man, without important antecedents, who presented colic-type abdominal pain, diffuse, intermittent, progressive, accompanied by nausea and vomiting of gastro-biliary content in multiple occasions and unable to canalize gases. Physical exploration revealed: no fever, severe dehydration, pale, no cardiopulmonary alterations, flat abdomen painful to mid and profound palpation of the lower hemiabdomen, without data of peritoneal irritation, diminished peristalsis. Thorax X rays revealed no subphrenic free air, plain abdominal X rays showed small air levels in the small intestine at the mesogastrium and left iliac fosse, no gas in the colon, and no important dilation of the small intestine. The exploratory laparotomy revealed intestinal obstruction secondary to a volvulus of the small intestine due to a Meckel’s diverticulum joined to the umbilical scar by a band and misrotation of the colon, with the Treitz liga

Exploratory laparotomy

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SYSTEMIC LUPUS ERYTHEMATOSUS. Molecular basis of disease Part 2

IJAR - Indian Journal of Applied Research (2019)

Eliseo Ruiz Bedolla Briceida López Martínez Israel Parra Ortega

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La fórmula de Friedewald no debe ser utilizada para el cálculo de colesterol de baja densidad en pacientes con triglicéridos elevados

Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio (2007)

Israel Parra Ortega Vanesa Jonguitud Díaz

La formula de Friedewald es un metodo empleado para estimar el colesterol-LDL (C-LDL) pero es inexacta si la concentracion de los trigliceridos sericos es superior a 400 mg/dL. Material y metodos: Se incluyeron 25 pacientes del sexo masculino con un nivel de trigliceridos mayor de 400 mg/ dL. Adicionalmente, se realizaron las determinaciones de colesterol total y de distintas densidades. Para obtener el valor del colesterol de baja y muy baja densidad se utilizo la formula de Friedewald y una formula alterna. Resultados: Los valores obtenidos de C-LDL por la formula de Friedewald se encuentran en el intervalo de -15.6 a 189.6, la media de 85.11 y la mediana de 79 mg/dL. Con la formula alterna los valores fueron de 98 a 282, con una media de 174.16 y la mediana de 169 mg/dL. Al realizar un analisis de regresion lineal simple de los valores de C-LDL obtenidos por la formula de Friedewald y por la formula alterna se obtuvo un valor de r = 0.54, la diferencia de los valores de CLDL obtenida con un valor de p = 0.0007. Conclusiones: La inexactitud de la formula de Friedewald hace imperativo unificar los criterios para el calculo del C-LDL en los pacientes que tienen una concentracion serica de los trigliceridos mayor de 400 mg/dL si no se cuenta con los recursos para realizar la determinacion directa

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CANCER: ETIOLOGY, CONTROL AND NUTRITION

Indian Journal Of Applied Research (2024)

Eliseo Ruiz Bedolla Israel Parra Ortega

Cancer is the leading cause of death in the world; and cancer treatments are becoming more expensive and there are not resources available in any institution or government for their cure. In 2020, there were 19.3 million new cases and around 10 million deaths and 28.4 million cases are expected by 2024. The most common types of cancer are breast, lung, colon and rectum and prostate; approximately 30% are due to tobacco use, alcohol consumption, low fruit and vegetable intake, and lack of physical activity; as well as infections caused by hepatitis viruses or human papillomaviruses. Cancer in children and adolescents is one of the leading causes of death in the worldwide. Each year, more than 400,000 children are diagnosed globally. In children, leukemias are more common, then brain tumors, and then lymphomas. This makes it a public health problem in Mexico and the worldwide. Amino acids stimulate cell growth and development cellular. Polyamines are the integrated part of the cellular and genetic metabolism and help in transcription, translocation, signaling and post-translational modications. Polyamines binding to RNA leads to structural changes which stimulate and increase the protein synthesis along the amino acids may inuence the conditions of various diseases. Several diseases can be controlled to a higher extend via maintaining the metabolism of amino acids and polyamines. On the other hand, a controlled diet is a way to maintain the level of amino acids and polyamines in the body. Present review highlights to etiology of cancer, also discusses functions and metabolism of polyamines in human and also highlights the nutritional role of amino acids and polyamines in the prevention and control of various diseases.

Etiology

10.36106/ijar/8110477

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Colesterol de baja densidad en pacientes con triglicéridos elevados: estudio en una población seleccionada

Medicina Interna de México (2007)

Héctor García Alcalá Larisa Estrada Marín R. Ariel Gómez Vanesa Jonguitud Díaz Israel Parra Ortega

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Trombofilia multifactorial en México: descripción del caso de 18 pacientes mestizos mexicanos con el síndrome de las plaquetas pegajosas

Medicina Interna de México (2006)