Vergilio A.R. Colturato

Hospital Amaral Carvalho

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Nelson Hamerschlak

Hospital Israelita Albert Einstein

Luís Fernando S. Bouzas

Instituto Nacional do Câncer

Afonso Celso Vigorito

Universidade Estadual de Campinas (UNICAMP)

Vaneuza Araújo Moreira Funke

Universidade Federal do Paraná

Noemi F. Pereira

Hospital de Clínicas Universidade Federal do Paraná

Celso Arrais‐Rodrigues

Universidade Nove de Julho

Marcos Augusto Mauad

Hospital Amaral Carvalho

Izabella Salomão

Instituto Nacional do Câncer

Maria Elisa de Moraes

Margareth Afonso Torres

Hospital Israelita Albert Einstein

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Universidade de São Paulo

Hospital Amaral Carvalho

Hospital Israelita Albert Einstein

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Hospital São Paulo

Universidade Federal de São Paulo

Instituto Nacional do Câncer

Universidade Estadual de Campinas (UNICAMP)

Hospital de Clínicas Universidade Federal do Paraná

Universidade Federal do Paraná

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Results of a Distance-Learning Tutorial for Brazilian Centers on How to Insert Data in the CIBMTR Registry

Biology of Blood and Marrow Transplantation (2018)

Cinthya Correa Silva Heliz Regina A. Neves Anderson João Simioni Marcelo C. Pasquini Vergilio A.R. Colturato

Background: According to the Brazilian Organ Transplantation Association (ABTO), 2,187 hematopoietic stem cell transplantation (HSCT) were performed in Brazil in 2016. The Center for Blood and Marrow Transplant Research (CIBMTR) is an international network of bone marrow transplantation centers that maintains a large, public, clinical database focused on outcomes. Objectives: We aimed to analyze the results of a tutorial for Brazilian transplant centers on the insertion of data in the CIBMTR. Methods: Three Brazilian transplantation centers developed and implemented a web-based distance-learning tutorial from June 1, 2016 to February 2, 2017, teaching center representatives to complete the TED (Transplant Essential Data) forms, and encouraging national centers to report data to the CIBMTR. The results were compiled from the Adobe Connect and CIBMTR databases. An online satisfaction survey was performed using 0-10 scores and asking if the participant would indicate the course to a colleague. The survey also evaluated the applicability of the courses to the routine. Results: The course "Guide to Pre- and Post- Transplant Data Completion" had the participation of 55 Brazilian centers, and 110 representatives completed module #1 (Pre-TED) and 27 completed module #2 (Post-TED form). Nurses comprised 24% (33) of participants. Most satisfaction scores were 8, 9 and 10 (Table 1), for each item, and 72.4% (35) of participants would indicate the Pre-TED course and 93.4% (14) the post-TED to a co-worker. The content was considered applicable to the routine for 66.7% (28, for the Pre-TED) and 86.7% (13, post-TED). In the first semester of 2017, a new center has already joined the CIBMTR databank.Table 1Positive Responses on Satisfaction with the Online Distance Tutorial: Number of Participants Who Scored 8-10 in Each ItemPre-TEDPost-TEDPositive responses to itemsN(%)N(%)Would you indicate this course to a colleague?3572.41493.4Is the tutorial content up-to-date?3685.615100Can you use what you learned in your routine?2866.71386.7Were the educational strategies good?3073.21493.4Were the access and navigation easy?3380.51386.7Were the additional resources such as videos and audios accessible?2970.71386.6 Open table in a new tab Conclusion: The distance-learning tutorial positively influenced the registration of data to the CIBMTR, demonstrated by the number of centers participating in the training, the indication of the course to another person and the increase of an active center in the CIBMTR database. The recognition of the course, at national and international levels, strengthens the investments in this type of education initiative, for new centers as well as for those who already carry out this registering activity.

Bone transplantation

10.1016/j.bbmt.2017.12.561

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Seleção de doador de medula óssea ou sangue periférico

Revista Brasileira de Hematologia e Hemoterapia (2010)

Noemi F. Pereira Danielli C. M. Oliveira Margareth Afonso Torres Celso Arrais‐Rodrigues Iracema S. B. Alencar

A compatibilidade HLA é o fator mais valorizado na escolha do doador de medula óssea voluntário, preconizando-se a realização de HLA de alta resolução nos locos HLA-A,B,C, DRB1 e DQB1. Tem sido dado preferência para o doador com consanguinidade alélica 8x8 (A,B,C, DRB1). Na presença de incompatibilidade na classe-I sugere-se a busca de doador com compatibilidade DQB1 (9x10). Já as incompatibilidades dos locos DPB1 não constituem critério de exclusão de doador, exceto quando existir presença de anticorpo contra o loco HLA-DP do doador.

10.1590/s1516-84842010005000022

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Development of Forms for a Tutorial of Transplant Essential Data (TED) as Facilitator to Understand and Learn About Data Entry in CIBMTR (Center for International Blood and Marrow Transplant Research) to Brazilian Centers

Biology of Blood and Marrow Transplantation (2017)

Cinthya Correa Silva Adenildo Felix Ribeiro Anderson João Simioni Heliz Regina A. Neves Vergilio A.R. Colturato

The CIBMTR aims to compile, analyze and standardize HSCT data (Hematopoietic Stem Cell Transplantation) through the creation and completion of specific forms generating a possibility of outcomes analysis, national and international benchmarking, multicenter studies and scientific production. In 2010, 64.96% of the HSCT performed in Brazil (18 centers) were reported to CIBMTR. This number fell to 25.31% (8 centers), in 2015. In order to facilitate and encourage the participation of Brazilian national centers a tutorial was created through which Captivate Program managed to capture the form filling images. The course has been elucidated by the description of a case with pre-additional and post-transplant information and content which guide data entry forms at TED. The e-learning tool to enable case and data managers was developed and validated during the period from June to September 2016 at the Hospital Israelita Albert Einstein (São Paulo / Brazil), by the onco-hematology and e-learning teams with the support from partner centers such as: CIBMTR, Milwaukee / USA; Amaral Carvalho Hospital, Jaú / Brazil; Hospital de Clinicas, Curitiba/ Brazil and SBTMO (Brazilian Association of Bone Marrow Transplantation), São Paulo/ Brazil. The product developed by the centers that have joined their efforts resulted in an extremely useful tool that along with other incentives and through translation also into Spanish shall raise awareness and encourage Brazil and other Latin American countries to register their data.

Facilitator

Bone transplantation

10.1016/j.bbmt.2016.12.136

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CONSTRUCTION OF A MULTIDISCIPLINARY STUDY GROUP ON HEMATOPOIETIC STEM CELL TRANSPLANTATION INVOLVING SEVERAL CENTERS IN BRAZIL – AS MEMBERS OF AMARTE ALLIANCE.

Hematology Transfusion and Cell Therapy (2024)

ASS Ibanez NC Villela R. de C. S. Dias Vergilio A.R. Colturato CM Lustosa

10.1016/j.htct.2024.09.1729

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Six cases of leprosy associated with allogeneic hematopoietic SCT

Bone Marrow Transplantation (2007)

Fabiano Pieroni Ana Beatriz P. L. Stracieri Daniela A. Moraes EJA Paton Fabiano Pinto Saggioro

10.1038/sj.bmt.1705824

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Outcomes after Hematopoietic Cell Transplantation (HCT) in Brazil for Children and Adolescents with Non-Malignant Diseases: A Multicenter Study on Behalf on the Brazil-Seattle Consortium Study Group

Biology of Blood and Marrow Transplantation (2018)

Carmem Bonfim Simone De Castro Resende Franco Vergilio A.R. Colturato Juliana Folloni Fernandes Victor Gottardello Zecchin

Background: HCT is the treatment of choice for many children with non-malignant diseases. The aim of this study is to determine major transplant outcomes among pediatric patients (pts) transplanted in Brazil. Patients and methods: This retrospective study included 300 pts with Bone Marrow Failures syndromes (65%, n = 193), Primary Immunodeficiencies (24%, n = 72), Inborn Errors of Metabolism (7%, n = 22) and Hemoglobinopathies (4%, n = 13) who received first allo-HCT between 2010 and 2014 at 11 Brazilian BMT centers. All pts received unmanipulated bone marrow (BM, 86%) or cord blood (CB, 14%) grafts. HCT donors included match related (MRD, n = 140, 47%), fully matched unrelated (MUD, n = 108, 36%) and mismatched unrelated (MM-URD, n = 52, 17%). Reduced intensity conditioning was given to 167 pts (56%). Most (78%) received GVHD prophylaxis with calcineurin inhibitor plus methotrexate. Grading of aGVHD and cGVHD were per Glucksberg and NIH criteria and were uniform among all centers. Results: Median age was 8 y/o (range, .6 to 17) and 62% (n = 185) were male. With median follow up of 4.5 years, 4y-overall survival (OS) was better for MRD compared to matched URD or mismatched URD transplants (84% versus 71% versus 69%, respectively; P = .01). When compared MM-URD BM (n = 26), matched (n = 11) or mismatched unrelated CB (n = 26) transplant pts had a lower OS (HR = 2.73; P = .04). Twenty-two pts died before D+21 and therefore were not evaluable for engraftment. Primary graft failure (GF) was observed in 21 pts and was significantly higher after mismatched CB transplants (OR = 7.43; P = .03) compared to MM-URD BM transplants. 257 pts engrafted and 22 developed secondary GF at a median of 193 days (range, 39-431). Acute GVHD grade II-IV occurred in 47 pts at a median of 28 days after HCT with a cumulative incidence (CumInc) at 3 months of 16% (95% CI, 11-20). Chronic GVHD was reported in 60 pts at a median of 189 days after HCT with a CumInc at 2 years of 20% (95% CI, 15-24). Acute and chronic GVHD CumInc were not significantly different across all donor types. Seventy-three pts died at a median of 69 days after HCT. Major causes of death included infection (51%) and GVHD (15%). One-year and 100-days TRM were 20% (95% CI, 15-24) and 17% (95% CI, 13-22), respectively. Conclusions: Children and adolescents with non-malignant diseases can achieve excellent outcomes after HCT from MRD in Brazil. We observed a high early mortality after HCT from unrelated CB donors in our study. For children lacking MRD, an URD donor is a suitable option, particularly from a MUD. Confirming earlier reports, incidence of chronic GVHD was low in this setting. This is the first pediatric multicenter study in Brazil for nonmalignant diseases and future studies will focus on strategies to reduce early mortality after unrelated CB HCT and will explore the role of HCT from haploidentical donors for children lacking MRD or MUD.

Cord blood

10.1016/j.bbmt.2017.12.529

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DIAGNOSIS AND TREATMENT OF GVHD

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY (2021)

Vaneuza Araújo Moreira Funke Maria Cláudia Rodrigues Moreira Antônio Vaz de Macedo Andresa Melo Jayr Schmidt Filho

THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION

10.46765/2675-374x.2021v4n1p164-173

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GVHD PROPHYLAXIS WITH METHOTREXATE IN HAPLOIDENTICAL HCT USING POSTTRANSPLANT CYCLOPHOSPHAMIDE: A PHASE IB/II CLINICAL TRIAL (NCT04622956)

Hematology Transfusion and Cell Therapy (2024)

Giancarlo Fatobene AM Ferreira LJ Otuyama LB Ribeiro Iago Colturato

10.1016/j.htct.2024.09.1682

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Seleção de doador não aparentado

Revista Brasileira de Hematologia e Hemoterapia (2010)

Margareth Afonso Torres Danielli C. M. Oliveira Noemi F. Pereira Iracema S. B. Alencar Celso Arrais‐Rodrigues

Apesar da presença de anticorpos anti-HLA em transplantes de órgãos sólidos estar associada à rejeição, essa correlação não havia sido pesquisada em transplante alogênico de células progenitoras hematopoéticas (TCPH). Estudos mais recentes na literatura têm demonstrado que a falência da enxertia no TCPH pode ser mediada por aloanticorpos anti-HLA doador especifico (DSA). A especificidade desses anticorpos pode ser evidenciada pelas técnicas de fase sólida, onde os antígenos HLA únicos são aderidos a pérolas de poliestireno, que permite a realização da prova cruzada virtual. Na presença de DSA, é recomendável selecionar outro doador ou realizar as estratégias de remoção dos anticorpos.

10.1590/s1516-84842010005000025

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Chronic GVHD Treatment in Brazil: Analyses of Failure Free Survival

Transplantation and Cellular Therapy (2021)

Afonso Celso Vigorito Eliana Cristina Martins Miranda Vergilio A.R. Colturato Anderson João Simioni Vaneuza Araújo Moreira Funke

10.1016/s2666-6367(21)00327-4

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