William D. Travis

Armed Forces Institute of Pathology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

James H. Shelhamer

National Institutes of Health Clinical Center

Frederick P. Ognibene

Armed Forces Institute of Pathology

Gregg Y. Lipschik

University of Pennsylvania

Henry Masur

National Institutes of Health Clinical Center

Henry D. Tazelaar

Mayo Clinic in Arizona

B. S. Bhagavan

Johns Hopkins Hospital

Eisei Nishino

Kishiwada Tokushukai Hospital

Irwin M. Feuerstein

MedStar Health

Neil E. Caporaso

National Institutes of Health

Tokunori Kawaguchi

Wakayama Rosai Hospital

Cooperative Institutions

National Institutes of Health

National Cancer Institute

National Institutes of Health Clinical Center

Mayo Clinic

National Institute of Allergy and Infectious Diseases

Mayo Clinic in Arizona

Harvard University

Wakayama Rosai Hospital

City Of Hope National Medical Center

Norwegian Womens Public Health Association

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Sarcomatoid renal carcinoma with angiosarcomatoid component

Urology (1992)

Peter J. Kragel William D. Travis F. J. Luibel

Immunoperoxidase

Desmin

Renal carcinoma

Sarcomatoid Carcinoma

10.1016/0090-4295(92)90396-e

Cite

Citations (11)

Primary Pulmonary Sarcoma With Morphologic Features of Monophasic Synovial Sarcoma and Chromosome Translocation t(X; 18)

American Journal of Clinical Pathology (1996)

Mark A. Kaplan M. David Goodman Jay Satish B. S. Bhagavan William D. Travis

The authors report an unusual spindle cell sarcoma that arose in the lung of a 12-year-old girl. This tumor had histologic, immunophenotypic, and ultrastructural features consistent with monophasic fibrous synovial sarcoma. These features included a growth pattern of densely packed spindle cells in irregularly intersecting, broad fascicles, diffuse vimentin immunoreactivity, and focal expression of epithelial membrane antigen and S100 protein. This diagnosis was further supported by cytogenetic studies showing the specific t(X;18) chromosomal translocation associated with synovial sarcoma. This balanced translocation appears to be an essentially universal characteristic of these sarcomas, regardless of histologic subtype or site of origin. The constellation of morphologic and cytogenetic findings in this case firmly establishes synovial sarcoma as a subtype of pulmonary spindle cell sarcomas. The distinctive features of these neoplasms allow them to be distinguished from a variety of primary and metastatic malignancies in the lung.

Synovial Sarcoma

10.1093/ajcp/105.2.195

Cite

Citations (66)

Atypical Pathologic Manifestations of Pneumocystis carinii Pneumonia in the Acquired Immune Deficiency Syndrome

The American Journal of Surgical Pathology (1990)

William D. Travis Stefania Pittaluga Gregg Y. Lipschik Frederick P. Ognibene A F Suffredini

The frequency of atypical pathologic manifestations of Pneumocystis carinii pneumonia (PCP) were studied in 123 lung biopsy specimens from 76 National Institutes of Health patients with the acquired immune deficiency syndrome. The following atypical features were observed: interstitial (63%) and intraluminal (36%) fibrosis, absence of alveolar exudate (19%), numerous alveolar macro-phages (9%), granulomatous inflammation (5%), hyaline membranes (4%), marked interstitial pneumonitis (3%), parenchymal cavities (2%), interstitial microcalcification (2%), minimal histologic reaction (2%), and vascular invasion with vasculitis (1%). These atypical features are discussed with emphasis on the significance of cavities, vascular invasion, vasculitis, and granulomas. Immuno-histochemical staining with monoclonal antibodies to the 2G2 and 6B8 antigens of P carinii in paraffin-embedded lung biopsy specimens did not indicate any diagnostic advantage over routine methenamine silver stains. This study provides an important reminder that a wide variety of pathologic manifestations may occur in PCP in human immunodeficiency virus-infected patients and that atypical features should be sought in lung biopsies from patients at risk for PCP.

Lung biopsy

10.1097/00000478-199007000-00002

Cite

Citations (151)

A Combined Small Cell and Spindle Cell Carcinoma of the Lung

The American Journal of Surgical Pathology (1992)

Yukari Tsubota Tokunori Kawaguchi Takanobu Hoso Eisei Nishino William D. Travis

A unique bronchial tumor is reported. The tumor grew as an endobronchial polyp and obstructed the right main bronchus. Histologically the lesion consisted of two different types of neoplastic cells; epithelial small cell nests and atypical spindle-shaped cells. Immunohistochemical studies with a panel of antibodies showed that the small cell nests were immunoreactive for epithelial and neuroendocrine markers. The spindle-shaped cells showed positive staining for smooth muscle actin. Epithelial markers were also positive focally in the spindle cells. Electron microscopy confirmed that the spindle-shaped cells had both epithelial and mesenchymal features. Based on these results, the tumor was considered to be a unique combination of small cell and spindle cell carcinoma.

Spindle cell carcinoma

10.1097/00000478-199211000-00010

Cite

Citations (41)

Lymphoid pneumonitis in 50 adult patients infected with the human immunodeficiency virus: Lymphocytic interstitial pneumonitis versus nonspecific interstitial pneumonitis

Human Pathology (1992)

William D. Travis Cecil H. Fox Kenneth O. Devaney Lawrence M. Weiss Timothy J. O’Leary

Hypersensitivity pneumonitis

Pneumonitis

NIP

Opportunistic infection

Interstitial pneumonitis

10.1016/0046-8177(92)90130-u

Cite

Citations (136)

p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer

Pharmacogenetics (1998)

Ronald M. Przygodzki William P. Bennett Donald G. Guinee Ateeb Khan Andrew N. Freedman

p53 mutation status was analysed in relation to DNA polymorphisms of GSTM1, CYP1A1 and CYP2E1 from 105 surgically resected non-small cell lung cancer cases. Demographic factors, smoking, occupation, family history, tumour histology, grade and stage were taken into account. p53 mutations, detected either directly by DNA sequencing (P = 0.04, adjusted for smoking) or indirectly by immunostaining (P = 0.06), were overrepresented among CYP1A1 variants. Mutations in exon 8 and transitions at CpG sites in the p53 gene were favoured in this subset. There was no relation between the individual gene polymorphisms or p53 mutations and disease-free survival by Kaplan-Meier analysis. The finding of excess CYP1A1 heterozygotes in individuals with p53 mutations after adjustment for smoking suggests that CYP1A1 activation contributes to lung Cancer via p53 inactivation.

Immunostaining

Heterozygote advantage

10.1097/00008571-199812000-00007

Cite

Citations (37)