Su-Ryun Jung

Washington University in St. Louis

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Kazuhiko Higashida

University of Shiga Prefecture

Yo Sasaki

Washington University in St. Louis

Sang Hyun Kim

Jeonbuk National University

Samuel Klein

Washington University in St. Louis

Jeong-Sun Ju

University of Suwon

Biplab Dasgupta

Cincinnati Children's Hospital Medical Center

Jeffrey Milbrandt

Washington University in St. Louis

Diana M. Lindquist

Cincinnati Children's Hospital Medical Center

Xiaona Liu

Northeast Agricultural University

Kenneth S. Polonsky

Prevention Group

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Washington University in St. Louis

University of Missouri–St. Louis

Hope Center for Neurological Disorders

Center for Neuro-Oncology

Pediatrics and Genetics

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Saint Louis University

Cincinnati Children's Hospital Medical Center

University of Cincinnati Medical Center

University of Cincinnati

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Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats

Metabolism (2012)

Dong-Ho Han Sang Hyun Kim Kazuhiko Higashida Su-Ryun Jung Kenneth S. Polonsky

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10.1016/j.metabol.2012.04.008

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Citations (19)

The AMPK β2 Subunit Is Required for Energy Homeostasis during Metabolic Stress

Molecular and Cellular Biology (2012)

Biplab Dasgupta Jeong-Sun Ju Yo Sasaki Xiaona Liu Su-Ryun Jung

AMP activated protein kinase (AMPK) plays a key role in the regulatory network responsible for maintaining systemic energy homeostasis during exercise or nutrient deprivation. To understand the function of the regulatory β2 subunit of AMPK in systemic energy metabolism, we characterized β2 subunit-deficient mice. Using these mutant mice, we demonstrated that the β2 subunit plays an important role in regulating glucose, glycogen, and lipid metabolism during metabolic stress. The β2 mutant animals failed to maintain euglycemia and muscle ATP levels during fasting. In addition, β2-deficient animals showed classic symptoms of metabolic syndrome, including hyperglycemia, glucose intolerance, and insulin resistance when maintained on a high-fat diet (HFD), and were unable to maintain muscle ATP levels during exercise. Cell surface-associated glucose transporter levels were reduced in skeletal muscle from β2 mutant animals on an HFD. In addition, they displayed poor exercise performance and impaired muscle glycogen metabolism. These mutant mice had decreased activation of AMPK and deficits in PGC1α-mediated transcription in skeletal muscle. Our results highlight specific roles of AMPK complexes containing the β2 subunit and suggest the potential utility of AMPK isoform-specific pharmacological modulators for treatment of metabolic, cardiac, and neurological disorders.

AMP-Activated Protein Kinase

Energy homeostasis

Homeostasis

10.1128/mcb.05853-11

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Citations (64)