ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Organic Sulfur Chemistry. I. The Disulfide-Phosphine Reaction. Desulfurization with Tris(diethylamino)phosphineDavid Harpp, John Gleason, and James SnyderCite this: J. Am. Chem. Soc. 1969, 91, 17, 4942Publication Date (Print):August 1, 1969Publication History Published online26 April 2004Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ja01045a600https://doi.org/10.1021/ja01045a600research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Abstract Die auf verschiedenen Wegen zugänglichen Verbindungen (V) werden in die Dicarbonsäuren (VII) umgewandelt, die mit dem StandardLeukotrien‐Antagonisten (I) verglichen werden.
We have examined in these studies the contractile activity of leukotrienes (LTs) C4, D4 and E4 on vascular ring segments obtained from several species and demonstrated that the distal segment of the guinea-pig pulmonary artery is a useful and convenient preparation for the study of LT vascular pharmacology. In vitro, LTs had no effect on aortic rings from rats, rabbits or guinea pigs. In contrast, LTs produced significant contraction of the distal portion of the pulmonary artery of the guinea pig. The rank of the contractile effects of LT was LTD4 = LTC4, greater than LTE4, with ED40 (molar) values of 6.1 X 10(-9), 1 X 10(-8) and 1.4 X 10(-6), respectively. Norepinephrine, serotonin and histamine were at least 50- to 100-fold less potent. Partial tolerance developed to the contractile action of LT in vitro. Vascular contraction produced by LTD4 was antagonized by a selective LT antagonist. No evidence for a relaxant action of LT was obtained as LTD4 and LTC4 failed to relax rabbit aorta or guinea-pig pulmonary arterial rings. The effects of LTD4 on hemodynamics in vivo were studied in anesthetized guinea pigs. LTD4 (0.1-10 micrograms/kg) significantly decreased cardiac output but increased pulmonary vascular resistance. To assess the activity of LTs in another species, the in vitro contractile response of monkey pulmonary artery was determined. LTD4 was also a potent contractile agent in this species with significant contraction obtained at 1 X 10(-9) M.(ABSTRACT TRUNCATED AT 250 WORDS)
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