Jerôme Barré

University Corporation for Atmospheric Research

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Vincent‐Henri Peuch

European Centre for Medium-Range Weather Forecasts

Richard Engelen

European Centre for Medium-Range Weather Forecasts

Anna Agustí‐Panareda

European Centre for Medium-Range Weather Forecasts

Antje Inness

European Centre for Medium-Range Weather Forecasts

Johannes Flemming

Queen's University

Mark Parrington

European Centre for Medium-Range Weather Forecasts

Zak Kipling

European Centre for Medium-Range Weather Forecasts

Melanie Ades

European Centre for Medium-Range Weather Forecasts

Jean‐Paul Tillement

Académie Nationale de Médecine

Benjamin Gaubert

NSF National Center for Atmospheric Research

Cooperative Institutions

Inserm

Université Paris Cité

Centre National de la Recherche Scientifique

European Centre for Medium-Range Weather Forecasts

Assistance Publique – Hôpitaux de Paris

NSF National Center for Atmospheric Research

University Corporation for Atmospheric Research

Université Paris-Est Créteil

University of Colorado Boulder

Sorbonne Paris Cité

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Does accounting for the direct-radiative effect of prognostic aerosols improve 5-day temperature forecast of the ECMWF weather forecast model ?

Johannes Flemming Alessio Bozzo Jerôme Barré Richard Engelen Sébastien Garrigues

The Copernicus Atmosphere Monitoring Service (CAMS) produces operationally global 5-day forecast of atmospheric composition and the weather using ECMWF&#8217;s Integrated Forecasting System (IFS) since 2015.Beginning with a system upgrade in June 2018 (45r1), the ozone and aerosol fields have been used in the radiation scheme to account for their radiative impact in the global CAMS forecasts. This approach replaced an aerosol and ozone climatology, which had been used before and which is still used in ECMWF's operational high-resolution medium-range NWP forecasts. The CAMS forecast system, which runs at a resolution of about 40 km, is applied here as a test-bed to explore the importance of aerosol direct feedback in an operational configuration, which can guide developments on composition-weather feedbacks for ECMWF's medium-range, monthly and seasonal forecasts.We will discuss the changes and improvements of temperature forecast errors (i) using typical NWP scores and (ii) by applying an event based approach that focuses on episodes of high aerosol burdens such as the transport of Sahara dust to Europe during the heatwave in June 2019. In more detail we will show to what extent the realism of the prognostic aerosol fields influences the temperature response by considering aerosol forecast which were, or were not, improved by data assimilation of aerosol optical depth at the start of the forecast. We will further demonstrate that the consistent updates of both the climatological and prognostic aerosol fields are an important prerequisite for a making progress.

10.5194/egusphere-egu2020-18254

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On the feasibility of monitoring carbon monoxide in the lower troposphere from a constellation of northern hemisphere geostationary satellites: Global scale assimilation experiments (Part II)

Atmospheric Environment (2016)

Jerôme Barré D. P. Edwards H. M. Worden Avelino F. Arellano Benjamin Gaubert

Trace gas

10.1016/j.atmosenv.2016.06.001

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Citations (9)

Evidence for a concentration-dependent polymerization of a commercial human serum albumin

Journal of Chromatography A (1981)

Roland Zini Jerôme Barré Françoise Brée Jean‐Paul Tillement Bernard Sébille

Human serum albumin

Bovine serum albumin

Serum Albumin

10.1016/s0021-9673(00)82347-x

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Citations (36)

Increase in the Vascular Residence Time of Propranolol-Loaded Nanoparticles Coated with Heparin

Journal of Nanoscience and Nanotechnology (2008)

M. Socha Alf Lamprecht Fatima El Ghazouani Emeric Emond Philippe Maincent

Propranolol-HCI incorporated nanoparticles prepared with a blend of a polyester and a polycationic polymer and coated or not with a low molecular weight heparin by electrostatic interactions were prepared by emulsification followed by solvent evaporation. The mean diameter was 388 and 357 nm for coated and uncoated nanoparticles, respectively, and the entrapment efficiency ranged from 20 to 32%. Coated nanoparticles were negatively-charged, whereas uncoated nanoparticles displayed a positive zeta potential (+30 mV). After intravenous administration to rabbits of propranolol-HCI solution and propranolol-loaded nanoparticles coated or not with heparin, pharmacokinetic data revealed that coated nanoparticles exhibited a prolonged blood residence time. It can be concluded that the hydrophilic layer of heparin at the surface of nanoparticles conferred stealth properties which probably reduce the phagocytosis process and avoid immediate uptake by the mononuclear phagocytic system.

Zeta potential

Suspension

10.1166/jnn.2008.081

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Citations (12)

DART data assimilation with CESM models [poster]

D. Raeder L. Anderson J. Hoar Stephen Collins Helen Kershaw

Dart

Assimilation (phonology)

Source

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Response to RC1

Jerôme Barré

10.5194/acp-2020-550-ac1

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Continuous Epidural Infusion of Bupivacaine for Postoperative Pain Relief in Children

Anesthesiology (1987)

Joëlle Desparmet Claude Meistelman Jerôme Barré Claude Saint-Maurice

Continuous Infusion

10.1097/00000542-198707000-00021

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Citations (100)

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

PLoS ONE (2010)

Xavier Durrmeyer Shushanik Hovhannisyan Yves Médard Evelyne Jacqz‐Aigrain Fabrice Decobert

Background Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may predict ibuprofen response. Methodology/Principal Findings We studied extremely preterm neonates with haemodynamically significant PDA and treated with ibuprofen. One or two variant CYP2C8 and/or 2C9 alleles were found in 17% of the population, most of them were from Caucasian ethnicity (67–74%). Response to ibuprofen and clinical course of infants carrying variants CYP2C8 and CYP2C9 were similar. Comparing infants with wild type or variant CYP2C8 and CYP2C9 genotypes, response rate to ibuprofen was significantly higher in wild type than in mutated carriers in univariate analysis (73% versus 52%, p = 0.04). Comparing responders (ductus closure; n = 75) and non-responders (surgical ligation; n = 36), the only two factors significantly associated with the response to ibuprofen using multivariate analysis were higher gestational age and non Caucasian ethnicity but not CYP2C polymorphism. Conclusions CYP2C polymorphism was not associated with PDA response to ibuprofen and this factor appears not appropriate to optimize the ductal closure rate by modulating ibuprofen dosing strategy. This study points out the role for ethnicity in the interindividual variability of response to ibuprofen in extremely preterm infants.

Ibuprofen

CYP2C8

Univariate analysis

Ductus arteriosus

10.1371/journal.pone.0012329

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Citations (42)

Shipborne measurements of XCO2, XCH4, and XCO above the Pacific Ocean and comparison to CAMS atmospheric analyses and S5P/TROPOMI

Earth system science data (2021)

Marvin Knapp Ralph Kleinschek Frank Hase Anna Agustí‐Panareda Antje Inness

Abstract. Measurements of atmospheric column-averaged dry-air mole fractions of carbon dioxide (XCO2), methane (XCH4), and carbon monoxide (XCO) have been collected across the Pacific Ocean during the Measuring Ocean REferences 2 (MORE-2) campaign in June 2019. We deployed a shipborne variant of the EM27/SUN Fourier transform spectrometer (FTS) on board the German R/V Sonne which, during MORE-2, crossed the Pacific Ocean from Vancouver, Canada, to Singapore. Equipped with a specially manufactured fast solar tracker, the FTS operated in direct-sun viewing geometry during the ship cruise reliably delivering solar absorption spectra in the shortwave infrared spectral range (4000 to 11000 cm−1). After filtering and bias correcting the dataset, we report on XCO2, XCH4, and XCO measurements for 22 d along a trajectory that largely aligns with 30∘ N of latitude between 140∘ W and 120∘ E of longitude. The dataset has been scaled to the Total Carbon Column Observing Network (TCCON) station in Karlsruhe, Germany, before and after the MORE-2 campaign through side-by-side measurements. The 1σ repeatability of hourly means of XCO2, XCH4, and XCO is found to be 0.24 ppm, 1.1 ppb, and 0.75 ppb, respectively. The Copernicus Atmosphere Monitoring Service (CAMS) models gridded concentration fields of the atmospheric composition using assimilated satellite observations, which show excellent agreement of 0.52±0.31 ppm for XCO2, 0.9±4.1 ppb for XCH4, and 3.2±3.4 ppb for XCO (mean difference ± SD, standard deviation, of differences for entire record) with our observations. Likewise, we find excellent agreement to within 2.2±6.6 ppb with the XCO observations of the TROPOspheric MOnitoring Instrument (TROPOMI) on the Sentinel-5 Precursor satellite (S5P). The shipborne measurements are accessible at https://doi.org/10.1594/PANGAEA.917240 (Knapp et al., 2020).

Longitude

10.5194/essd-13-199-2021

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Citations (22)

pH titration curves of the desialylated human α1-acid glycoprotein variants by combined isoelectrofocusing—electrophoresis: utilization in the development of a fractionation method for the protein variants by chromatography on immobilized metal affinity adsorbent

Journal of Chromatography B Biomedical Sciences and Applications (1992)

Françoise Hervé Jean-Claude Duché Jerôme Barré Marie‐Claude Millot J P Tillement

Immobilized pH gradient

Orosomucoid

Affinity electrophoresis

10.1016/0378-4347(92)80597-j

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Citations (24)