We analyzed data on 621 Japanese patients with gastric cancer treated with total gastrectomy, with respect to age of the patient. There were 123 patients aged 70 years and older. The mortality rate was 1.6% for the elderly patients and 1.4% for the others. In patients over the age of 70, there were fewer women and the differentiated tissue type was more common. The infiltrative Borrmann types 3 and 4 accounted for 53.6% of the elderly patients, serosal invasion was less prominent and the rate of peritoneal dissemination was lower. Extensive lymph node dissection (R2 or R3) was done for 65.9% of the elderly patients and the rate of curative resection was higher. There was no difference in survival rates among these patients. Liver metastasis, operative curability, serosal invasion, lymph node metastasis, tumor size and extensive lymph node dissection, but not age, proved to be independent prognostic factors for total gastrectomy, as determined by multivariate analysis. Thus, the outcome of surgery is good and the mortality rate is low in the elderly patients with gastric cancer undergoing total gastrectomy with lymphadenectomy and resection of adjacent organs. When considering the indications for total gastrectomy, the age of the patient should not be an untoward factor.

Lymphadenectomy

10.1159/000172179

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Laparoscopic cholecystectomy for cholecystolithiasis in a case with situs inversus totalis

Digestive Endoscopy (2002)

Masayuki Honda Fumio Takesue Mitsuhiro Yasuda Sadaaki Inutsuka Tadahiro Nozoe

We report a case of cholecystolithiasis associated with situs inversus totalis (SIT) that had been successfully treated with a laparoscopic cholecystectomy. Although cholecystolithiasis associated with SIT is rare, trained surgeons who perform unusual surgical procedures, even if they have not experienced such a case, would perform laparoscopic cholecystectomy for cholecystolithiasis associated with SIT easily and safely.

10.1046/j.1443-1661.2002.00196.x

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Clinical value of SDI test for predicting effect of postoperative chemotherapy for patients with gastric cancer

Seminars in Surgical Oncology (1994)

Hideo Baba Hideya Takeuchi Sadaaki Inutsuka Manabu Yamamoto Kazuya Endo

Abstract We retrospectively evaluated the clinical usefulness of the succinate dehydrogenase inhibition (SDI) test as a chemosensitivity test, using 168 resected specimens of gastric cancer, with special reference to the correlation between the results of the SDI test and clinical effects of the corresponding chemotherapy. The rate of sensitivity of these tissues to DDP, CQ, ACR, MMC, ADM, and 5‐FU were 63.5%, 54.2%, 47.4%, 42.9%, 31.4%, and 10.8%, respectively. Survival rates for patients with a positive chemosensitivity to MMC and postoperatively prescribed more than 20 mg of MMC were significantly better than those without sensitivity to MMC, even when treated with MMC, although no statistical differences existed in clinicopathologic factors between the two groups. We conclude that the SDI test for human gastric cancer is a rapid, reliable, and useful assay to determine the compatibility between the results of assay and the clinical effects of corresponding chemotherapy. We propose that the regimen of postoperative adjuvant chemotherapy be tailored according to results of the SDI test, using tissues resected from individual patients. © 1994 Wiley‐Liss, Inc.

Regimen

Adjuvant Chemotherapy

Chemosensitivity assay

Clinical Significance

10.1002/ssu.2980100216

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P4-08 Clinicopathological Significance of Cyclin B1 Overexpression in Human Colorectal and Gastric Cancer

ACTA HISTOCHEMICA ET CYTOCHEMICA (2002)

Mitsuhiro Yasuda Masayuki Honda Tadahiro Nozoe Sadaaki Inutsuka Daisuke Korenaga

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Hyperthermia Combined with Dipyridamole Enhance the Cytotoxicity of 5-Fluorouracil both in Vitro and in Vivo.

Thermal Medicine(Japanese Journal of Hyperthermic Oncology) (1994)

Sadaaki Inutsuka Hideo Baba Hideya Takeuchi Yoshihisa Sakaguchi Tetsuya Kusumoto

The combined effect of 5-FU, DP, and HT was investigated both in vitro and in vivo. When HeLa and B16 melanoma cells were exposed concomitantly ti heat (43' C, 40min) and DP (2.5 μg/ml), the cytotoxicity of 5-FU (0.1 μg/ml) was sugnificantly enhanced determined with colonergic assay. SDI test also revealed that this trimodality treatment was more cytotoxic to B16 melanoma cells and human cancer tissues than 5-FU alone.Growth of B16 melanoma that had been implanted subcutaneously was inhibited by DP (100mg/kg), and 5-FU (13.2mg/kg), when compared with 5-FU alone.Hyperthermia (HT) and dipyridamole (DP) augment the cytotoxicity of 5-fluorouracil (5-FU) in vitro and in vivo. The combination therapy of 5-FU, DP and HT is thought to be useful toward malignant diseases.

Dipyridamole

HeLa

10.3191/thermalmedicine.10.42

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