M. Neubauer

University of Stuttgart

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Christian Hauser

University of Applied Sciences of the Grisons

Steven B. Kanner

Caribou Biosciences (United States)

W L Cosand

Bristol-Myers Squibb (Germany)

Nikos Kalatzis

National Technical University of Athens

P Y Chan

Washington University in St. Louis

Aleksej Jerman Blažič

Security Technology Competence Centre

I. Orazem

Ioanna Roussaki

National Technical University of Athens

James Blake

QIMR Berghofer Medical Research Institute

Jim Clarke

Coventry University

Cooperative Institutions

Bristol-Myers Squibb (United States)

Bristol-Myers Squibb (Germany)

National Technical University of Athens

National and Kapodistrian University of Athens

Institute of Communication and Computer Systems

University of Washington

Caribou Biosciences (United States)

Arrowhead Pharmaceuticals (United States)

Astex Pharmaceuticals

Children's Hospital of Philadelphia

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[The mechanism of action of pirenzepin (gastrozepin), a new inhibitor of secretion].

PubMed (1978)

Gordon Heller U Karn M. Neubauer Althoff Ph Κ. Schöffling

Mechanism of Action

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Privacy-Aware Modelling and Distribution of Context Information in Pervasive Service Provision

Ioanna Roussaki Maria Strimpakou Carsten Pils Nikos Kalatzis M. Neubauer

Context awareness is an essential cornerstone in future pervasive computing systems. It has the potential to greatly reduce the user attention and interaction bottlenecks, to give humans the impression that services fade into the background, and to support intelligent personalization features. Nevertheless, in order to create such an environment, a growing amount of personal information has to be provided to the system, either manually or automatically. Hence the digital trace and representation users have in the system is getting dangerously detailed, thus stressing the need for privacy protection. DAIDALOS (Satyanarayanan, 2001) is a European research project in the area of 3G and beyond, which aims to combine heterogeneous networks in a transparent and seamless way, and develop on top of this a pervasive environment for applications and end-users. This paper describes the main models and mechanisms that have been established to provide federated context-aware services and protect the privacy of their users

Cornerstone

TRACE (psycholinguistics)

Context awareness

10.1109/perser.2006.1652219

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Citations (9)

Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125^FAK

DNA and Cell Biology (1993)

Gena S. Whitney P Y Chan James Blake W L Cosand M. Neubauer

Clustering of β1-integrins on adherent cells with antibodies or ligands results in increased tyrosine phosphorylation and activation of a novel focal adhesion tyrosine kinase, pp125FAK. The genes encoding pp125FAK have been cloned previously from both chicken and mouse cDNA libraries, and the deduced amino acid sequences are nearly identical (94%). Two synthetic peptides derived from sequences at the carboxyl terminus of chicken pp125FAK were conjugated to ovalbumin to generate rabbit heteroantisera. Human pp125FAK was immunodetected in both T and B lymphocytes with these antisera. A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. Additionally, the full-length sequence of human T-cell pp125FAK (huT-FAK) was derived from a Jurkat T-cell cDNA library. huT-FAK is structurally identical with both mouse and chicken FAK, and shares 95% amino acid identity with chicken pp125FAK and has 97% homology with the mouse sequence. This high degree of evolutionary conservation between species suggests that pp125FAK is likely to have a crucial function in the cell. Expression of the full-length huT-FAK gene in COS cells showed an immunologicaily indistinct human pp125FAK protein compared with the endogenous primate pp125FAK. Taken together, the data indicate that this structurally conserved human T-cell pp125FAK likely functions in T- and B-cell lineages, and its altered expression in human lymphocyte tumor cell lines may contribute to their transformed phenotype.

10.1089/dna.1993.12.823

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Citations (91)

Security and Privacy in a Pervasive World

Jim Clarke Shawna M. Butler Christian Hauser M. Neubauer Penny Robertson

DAIDALOS is a European project funded under the Sixth Framework, which aims to integrate a range of heterogeneous networks and to develop pervasive systems on top of them to provide the user with transparent access to personalised communication and information services in a complex environment. Security and privacy are key to the development of such a system. This paper addresses some major questions on how to build trust and confidence in complex environments of pervasive systems where many entities play different roles, mostly for some limited amount of time, and where a significant amount of personal related data travel through the network to deliver highly personalised services.

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Citations (9)