E. Jauniaux

University College London

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D. Jurkovic

University College London

Shanthi Muttukrishna

University College Cork

K. H. Nicolaides

King's College Hospital

Graham J. Burton

University of Cambridge

GJ Burton

University of Cambridge

Sylvain Meuris

Université Libre de Bruxelles

Paul Wilkin

Analog Devices (United States)

D. Stephen Charnock‐Jones

University of Cambridge

Béatrice Gulbis

Erasmus Hospital

C. Moroz

Rabin Medical Center

Cooperative Institutions

University College London

University College Hospital

Université Libre de Bruxelles

Erasmus Hospital

University of Cambridge

Centre Hospitalier Universitaire de Saint-Pierre

University of London

Royal London Hospital

University College London Hospitals NHS Foundation Trust

Tel Aviv University

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Rapid Determination of Fetal Sex in Coelomic and Amniotic Fluid by Fluorescence in situ Hybridisation

Fetal Diagnosis and Therapy (1995)

Pranav Pandya D.L.N. Cardy E. Jauniaux Stuart Campbell K. H. Nicolaides

Coelomic fluid (n = 32), amniotic fluid (n = 26) and placental tissue were obtained from 32 women undergoing termination of pregnancy at 7–11 weeks of gestation. Fluorescence in situ hybridisation (FISH) was performed to determine fetal sex using a heterochromatic Y probe and an alpha satellite repeat probe for chromosome X. In each case there was concordance in the fetal sex from the three compartments. However, no result could be obtained from 4 of the 32 coelomic fluids and 4 of the 26 amniotic fluid samples. The hybridisation efficiency was significantly lower in coelomic and amniotic fluid compared with placental tissue.

Coelom

CTD

10.1159/000264195

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Citations (7)

Prenatal diagnosis of an extensive fetal lymphangioma using ultrasonography, magnetic resonance imaging and cytology.

British Journal of Radiology (1997)

P. Kaminopetros E. Jauniaux P. A. Kane M.J. Weston K. H. Nicolaides

An unusual case of fetal lymphangioma diagnosed before delivery is reported in a second trimester pregnant woman. The lymphangioma was suspected at 28 weeks on the basis of the ultrasound appearances and progression of the lesions with advancing gestation. MRI was used to evaluate the extent and the tissue characteristics of the lesions. Cytology of the fluid aspirated from the cystic lesions showed abundant lymphocytes and macrophages, confirming the diagnosis of a lymphangioma. The parents opted for a pregnancy termination because of the rapid growth of the lesions and the poor prognosis. It is suggested that the combination of these tests could enable the early diagnosis of these tumours at a stage when the lesion is relatively limited and accessible to therapy in utero.

Lymphangioma

10.1259/bjr.70.835.9245887

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Citations (43)

Accreta Placentation: A Systematic Review of Prenatal Ultrasound Imaging and Grading of Villous Invasiveness

Obstetric Anesthesia Digest (2017)

E. Jauniaux Sally Collins D. Jurkovic G.J. Burton

( Am J Obstet Gynecol . 2016;215(6):712–721) Placenta accreta (PA) is the invasion or abnormal attachment of placental tissue to uterine musculature and can lead to major hemorrhage and other serious outcomes. There are 3 categories of PA: placenta creta, when villi only adhere to the myometrium but do not invade it; placenta increta (PI), in which the villi penetrate the myometrium only to the external layer; and placenta percreta (PP), in which the villi reaches or penetrates the uterine serosa.

Placenta Accreta

Myometrium

Placentation

Placenta Diseases

10.1097/01.aoa.0000527036.68068.6a

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Citations (1)

In vivo levels of inhibins, activin A and follistatin in early human pregnancy.

Shanthi Muttukrishna E. Jauniaux H H McGarrigle N P Groome

Follistatin

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Citations (1)

In-vivo measurement of intrauterine gases and acid–base values early in human pregnancy

Human Reproduction (1999)

E. Jauniaux Adrian Watson Özkan Öztürk Devon Quick Graham J. Burton

A new multiparameter sensor that combines electrochemical and fibre-optic technology was used for continuous in-vivo investigation of pH, carbon dioxide partial pressure (PCO2), oxygen partial pressure (PO2), bicarbonate concentration (HCO3–), base excess, and oxygen saturation (O2Sat) early in human pregnancy. The sensor was inserted into the amniotic cavity and the placental bed of 16 pregnancies at 10–15 weeks gestation, before termination under general anaesthesia. Amniotic fluid and retroplacental blood from the same site were also aspirated and analysed by means of cartridges and a portable blood gas analyser. Eleven series of measurements were obtained. The variation in measurements over the 5 min of monitoring was ≤10% for all parameters. The sensor was damaged during insertion into the amniotic cavity in one case and in the placental bed in four cases. Measurements of PO2 in both the amniotic cavity and the placental bed and of pH in the placental bed were higher using the cartridges than in vivo. The results indicated that in-vivo monitoring of fetoplacental gas and acid–base with a sensor is stable and accurate. Such technology will be helpful in improving our understanding of the fetoplacental metabolism in normal and complicated pregnancies.

Partial pressure

pCO2

Bicarbonate

10.1093/humrep/14.11.2901

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Citations (83)

Increased placental NAD(P)H oxidase mediated superoxide generation in early pregnancy

Proceedings of The Physiological Society (2003)

GJ Burton E. Jauniaux Lucilla Poston Mtm Raijmakers Paul T. Seed

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Citations (2)

The First Twelve Weeks of Gestation

Springer eBooks (1992)

Eytan R. Barnea J Hustin E. Jauniaux

Human reproduction

10.1007/978-3-642-84385-3

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Citations (69)

Distribution of lactate dehydrogenase isoenzymes in coelomic fluid and fetal adnexae

Placenta (1996)

Béatrice Gulbis E. Jauniaux

Decidua

10.1016/s0143-4004(96)90062-4

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Citations (4)

Influence of human chorionic gonadotrophin, oestradiol and progesterone on uteroplacental and corpus luteum blood flow in normal early pregnancy

Human Reproduction (1992)

E. Jauniaux D. Jurkovic J. Delogne-Desnoek Sylvain Meuris

A transvaginal colour and pulsed Doppler study was performed on 44 women with normal pregnancies between 5 and 16 weeks of gestation. Maternal levels of human chorionic gonadotrophin (HCG), free alpha-HCG subunit, free beta-HCG subunit, 17 beta-oestradiol and progesterone were determined in sera obtained at the time of Doppler examination. Uterine peak systolic velocity (PSV) and alpha-HCG and 17 beta-oestradiol levels increased significantly (P < 0.001) from the second to the fourth month of gestation, whereas uterine and spiral resistance index (RI) decreased significantly (P < 0.005 and P < 0.001, respectively) with gestational age. Levels of HCG and beta-HCG peaked significantly (P < 0.01) during the third month of gestation. Corpus luteum PSV and RI and progesterone levels did not vary significantly with gestational age. Multiple regression analysis showed that gestational age was the only significant (P < 0.05) contributor to uterine PSV and spiral RI variability. In addition to gestational age, 17 beta-oestradiol had a significant (P < 0.001) influence on uterine RI. Both corpus luteum PSV and RI were significantly (P < 0.01 and P < 0.05, respectively) related to progesterone levels. Corpus luteum PSV was also significantly (P < 0.05) related to 17 beta-oestradiol levels and RI to HCG levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Human chorionic gonadotropin

Gonadotropin

10.1093/oxfordjournals.humrep.a137596

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Citations (39)

The Placenta: Basic Science and Clinical Practice

John‏ Kingdom E. Jauniaux P.M.S. O’Brien

Clinical Practice

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Citations (57)