C W Fink

University of Michigan–Ann Arbor

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Peter Šťastný

Valparaiso University

Virgil Hanson

Children's Hospital of Los Angeles

Joseph E. Levinson

University of Michigan–Ann Arbor

John Baum

University of Vechta

Jane G. Schaller

British Columbia Children's Hospital

Earl J. Brewer

Baylor College of Medicine

Lauren M. Pachman

Lurie Children's Hospital

Marcelo Fernández-Viña

Stanford University

Jan M. Friedman

University of British Columbia

L. H. Paradies

University of Texas Health Science Center at Dallas

Cooperative Institutions

The University of Texas Southwestern Medical Center

University of Texas Health Science Center at Dallas

Northwestern University

Lurie Children's Hospital

The Ohio State University

Harvard University

The University of Texas Health Science Center at Houston

University of Lübeck

University of Michigan–Ann Arbor

Children's Hospital of Los Angeles

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RELATIONSHIP BETWEEN URINARY HYDROXYPROLINE AND GROWTH*

Journal of Clinical Investigation (1962)

Hugo E. Jasin C W Fink W. Wisf M Ziff

Beginning with the report of Ziff, Kibrick, Dresner, and Gribetz (2), evidence accumulated in recent years has indicated that urinary hydroxyproline excretion reflects collagen metabolism, since collagen is the only protein in the body that contains hydroxyproline in significant amounts (3).Ziff and co-workers, observing that the excretion of this amino acid in peptide form was greater in children than in adults, suggested that the level of urinary hydroxyproline might be re- lated to the size of the metabolically active, solu- ble collagen pool available for breakdown.The results of a number of investigations (4-7) have supported this suggestion.In the present paper, further investigation of the relationship between growth and hydroxypro- line excretion has been carried out in man.Uri- nary hydroxyproline has been determined in pa- tients with normal, arrested, and accelerated growth, and in cases in which arrested growth has been stimulated by hormonal therapy.The data obtained indicate that the level of excretion of hydroxyproline shows a good correlation with rate of growth under all circumstances studied and, therefore, offers a useful and readily meas- ured index of this phenomenon. METHODS AND MATERIALSNormal controls.Urines from normal children and adults were collected at home.In the 0-to 1-year group, the urine was collected in absorbent diapers with a special tissue paper sheet to isolate the feces.Diapers were changed six times in 24 hours.Upon removal, they were immersed in water saturated with toluene, and at the end of a 24-hour collection period, centrifuged in * Work

Hydroxyproline

10.1172/jci104650

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Citations (196)

Author Index

The American Journal of the Medical Sciences (2001)

See Tsiouris N See Karim Cadogan Ma See Rapoport A Chitkara

10.1016/s0002-9629(15)34550-x

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651 GROWTH & DEVELOPMENT OF INFANTS < 1500 g FED BANKED HUMAN MILK (BHM) OR PREMATURE FORMULA (F)

Pediatric Research (1981)

Jon E. Tyson Robert E. Lasky Charles E. Mize R. J. White C W Fink

Calorie

10.1203/00006450-198104001-00664

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Citations (10)

Synovectomy in juvenile rheumatoid arthritis.

Annals of the Rheumatic Diseases (1969)

C W Fink John Baum L. H. Paradies BRANDON CARRELL

Synovectomy has been one of the forms of therapy in adult rheumatoid arthritis for about 15 years.

Synovectomy

Juvenile rheumatoid arthritis

10.1136/ard.28.6.612

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Citations (24)

953 IMMUNOGENETICS OF JUVENILE DERMATOMYOSITIS (JDMS), A COLLABORATIVE STUDY

Pediatric Research (1981)

Lauren M. Pachman Mona C. Maryjowski Jan M. Friedman Olga Jonasson Ruta Radvany

Juvenile Dermatomyositis

Ophthalmoparesis

Raji cell

10.1203/00006450-198104001-00978

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Citations (2)

Food systems literacy and critique

Routledge eBooks (2022)

Liz Nix C W Fink

Through the globalisation of food and the nutrition transition, consumers have become increasingly disconnected from the source and distribution systems of their food, as well as the people, processes, and policies that are involved in food acquisition. Food system literacy implies that consumers should be knowledgeable about the entirety of the food system in order to make choices that are nutritious as well as sustainable. Some food literacy programs promote specific aspects of the food system but may not address the complexities of systems thinking. In addition, consumers alone should not be responsible for making beneficial changes to the food system. Food systems thinking should also be promoted for food system stakeholders, both primary (food producers and distributors) and peripheral (nutritionists, social justice advocates, politicians), to foster sustainable changes across the food system.

10.4324/9781003174417-25

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Different HLA-D associations in adult and juvenile rheumatoid arthritis.

Journal of Clinical Investigation (1979)

Peter Šťastný C W Fink

HLA-D typing was performed in 126 patients with juvenile rheumatoid arthritis. HLA-DW4, the antigen found in previous studies to characterize adult rheumatoid arthritis, had a significantly lower frequency in children with arthritis than in normal controls (P less than 0.04). By contrast, in children the antigens HLA-DW7 (P less than 0.03) and HLA-DW8 (P less than 0.01) were increased compared to controls. The antigen TMo, detected with homozygous typing cells from a child with juvenile rheumatoid arthritis, was found to be related to the cross-reactive specificities HLA-DW7 and DW11. 46% of the patients with persistent pauciarticular arthritis of childhood typed for the antigen TMo, compared to only 1% of normal controls. Thus the relative risk for persistent pauciarticular arthritis in relation to the presence of TMo was 67.7 (P less than 0.0001). These results provide evidence of fundamental differences between adult rheumatoid arthritis and arthritis of childhood. The latter group appears to include a population distinguishable clinically and characterized in these studies by the HLA-D determinant TMo.

Juvenile rheumatoid arthritis

Subclass

10.1172/jci109265

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Citations (133)

HLA associations in juvenile arthritis.

PubMed (1994)

Marcelo Fernández-Viña C W Fink Peter Šťastný

This review of the current status of HLA associations in juvenile arthritis begins with a discussion of the terms used to identify these patients and an approach for their clinical classification. The authors suggest that seven different types should be identified on the basis of clinical features and associated immunogenetic factors and that each of them should be recognized and called by a separate name. Different combinations of patients have been included in the studies performed in different cities and this fact may explain some of the observed differences in HLA associations in various reports. Results from an on-going study in Dallas are compared with published reports from Prague, Cincinnati, and Houston. HLA alleles associated with susceptibility in pauciarticular patients include certain DR and DQ alleles, one DP allele (DPB1*0201) and one HLA class I allele (HLA-A*0201). Susceptibility for polyarticular onset disease was found by the authors to be uniquely associated with DPB1*0301. Important interactions were observed between alleles at the different loci, with markedly increased odds ratios when combinations of susceptibility alleles were analyzed. The possibility that interaction between class I and class II susceptibility factors might be due to the effect of an allele at one of the TAP loci was examined by probing for polymorphic variants of the TAP1 and TAP2 genes. In addition, class I alleles associated with resistance for the development of juvenile arthritis were discussed. The main allele associated with rheumatoid arthritis (DRB1*0401) appears to be protective for the development of several forms of arthritis prevalent in children.

Juvenile rheumatoid arthritis

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Citations (34)

Effect of hyperthyroidism and hypothyroidism on collagen metabolism.

PubMed (1967)

C W Fink J L Ferguson J. Donald Smiley

Hydroxyproline

Catabolism

Methimazole

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Citations (28)

Systemic lupus erythematosus presenting as thrombotic thrombocytopenic purpura.

PubMed (1990)

O G Jonsson C W Fink

We describe a 10-year-old girl, who presented with thrombotic thrombocytopenic purpura (TTP) and shortly thereafter developed systemic lupus erythematosus (SLE). The association between TTP and SLE is known, but this is the first report of SLE presenting as TTP.

Purpura (gastropod)

Thrombocytopenic purpura

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Citations (22)