Joseph L. Haining

University of Mississippi Medical Center

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Robert R. Smith

University of Florida

Ben R. Clower

University of Mississippi Medical Center

Jim S. Legan

University of Mississippi

Yutaka Honma

Showa General Hospital

Bernard Axelrod

Arizona State University

W. W. Correll

United States Department of Veterans Affairs

Yoshihiro Yamamoto

Jichi Medical University

Shri K. Mishra

National Institute Of Technology Silchar

Mark D. Turner

Nottingham Trent University

Duane E. Haines

Wake Forest University

Cooperative Institutions

University of Mississippi Medical Center

University of Mississippi

Jackson Memorial Hospital

United States Department of Veterans Affairs

State Street (United States)

Neurological Surgery

National Institutes of Health

Jackson College

University of Tennessee at Knoxville

Oak Ridge National Laboratory

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Measurement of local skeletal muscle blood flow in normal humans by hydrogen clearance

Muscle & Nerve (1980)

Shri K. Mishra Joseph L. Haining

Abstract The hydrogen (H 2 ) electrode technique was adapted to the measurement of local skeletal muscle blood flow (LSMBF) in humans. Thirty‐five normal volunteers were utilized to study the biceps, deltoid, gastrocnemius, and quadriceps muscles at rest and following exercise. Results indicated statistically significant increases ( P < 0.05) in postexercise compared with resting blood flows within the muscles. The highest mean value for LSMBF was found in deltoid muscle and the lowest in biceps. This study demonstrates the potential superiority of the H 2 electrode technique over previous techniques for measuring absolute muscle blood flow at individual sites. It is suggested that measurements by means of the H 2 electrode technique represent the most definitive values for skeletal muscle blood flow at this time, and its application could be especially important in various neuromuscular disorders in which some question remains concerning the role of abnormalities of the skeletal muscle vasculature.

Deltoid curve

Deltoid muscle

Biceps brachii muscle

10.1002/mus.880030403

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Citations (7)

Synthesis and Degradation of Rat Liver Xanthine Oxidase as a Function of Age and Protein Deprivation

Journal of Gerontology (1970)

Joseph L. Haining Jim S. Legan W. Lovell

Journal Article Synthesis and Degradation of Rat Liver Xanthine Oxidase as a Function of Age and Protein Deprivation Get access Joseph L. Haining, PhD, Joseph L. Haining, PhD Search for other works by this author on: Oxford Academic PubMed Google Scholar Jim S. Legan, BS, Jim S. Legan, BS Search for other works by this author on: Oxford Academic PubMed Google Scholar Winfred J. Lovell, BS Winfred J. Lovell, BS 1Biochemistry Research Laboratory, Veterans Administration CenterJackson, Mississippi 39216. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 25, Issue 3, July 1970, Pages 205–209, https://doi.org/10.1093/geronj/25.3.205 Published: 01 July 1970

10.1093/geronj/25.3.205

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Citations (13)

Measurement of Local Cerebral Blood Flow in the Unanesthetized Rat Using a Hydrogen Clearance Method

Circulation Research (1968)

Joseph L. Haining Mark D. Turner RALPH M. PANTALL

The hydrogen clearance method for measuring local tissue blood flow was adapted for use in the brain of the unanesthetized rat by means of a stainless steel plate screw mounted in the skull as the reference electrode instead of a calomel electrode. Blood flow was measured at 3 sites in the brains of 5 three-month-old rats over a 6-week period. Blood flow in the frontal cortex and the cerebellum for all the animals averaged 79 ± 22 (SD) and 81 ± 25 ml/min/100 g tissue, respectively. The other site, supposedly the hippocampus, exhibited a two-component clearance curve in most cases. The initial rapid component was of questionable validity; the second slow component averaged 110 ± 23 ml/min/100 g. Autopsy revealed that the hippocampal electrode was actually positioned in more than one type of tissue or proximal to an interspace. Hypoxia (Po 2 = 50 mm Hg) and hypercapnia (produced by inhalation of 10% CO 2 ) increased the clearance rates two- to four-fold. The rate of local blood flow and its variability were affected by the state of the animal; anesthesia (sodium pentobarbital) decreased the rate of blood flow as anticipated, and markedly reduced the variation in rate seen in the conscious state.

Arterial blood

10.1161/01.res.23.2.313

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Citations (96)

Intracisternal blood injections fail to produce cerebral angiopathy in cats

Experimental Neurology (1986)

Ben R. Clower John P. Kapp Norman A. Moore Robert R. Smith Joseph L. Haining

Subarachnoid space

Pons

Angiopathy

Medulla

10.1016/0014-4886(86)90103-2

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Citations (4)

Kinetics of Induction of Rat Liver Enzymes by Glucocorticoids

Molecular Pharmacology (1970)

Joseph L. Haining

The hypothesis that cortisone increases the synthesis of a group of rat liver enzymes to the same extent, and that their relative rates of accumulation are consequently determined by their respective degradative rate constants, is re-evaluated in terms of the original data and assumptions. The data do not for the most part conform to the changes in enzyme levels predicted by the kinetic model. A fundamental assumption upon which the original conclusions were based is shown to be erroneous; i.e., the initial rate of enzyme accumulation is not a valid estimate of the induced rate of enzyme synthesis. A rearrangement of the equation for enzyme accumulation permits calculation of the induced synthetic rate for any segment of the accumulation curve. Solutions of the equation are consistent with the concept of a lag period in the induction of tryptophan oxygenase (L-tryptophan:oxygen oxidoreductase, EC 1.13.1.12), tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, EC 2.6.1.5), and alanine aminotransferase (L-alanine:2-oxoglutarate aminotransferase, EC 2.6.1.2) in adrenalectomized rats. Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) was synthesized at a fairly constant induced rate from the earliest measured point in time, while the synthesis of alanine aminotransferase appeared to rise to a maximum at 1-2 days and then to decline to about half this value at the induced steady-state level. These kinetic analyses provide no support for the original hypothesis, or for the generalization that differences in accumulation rates of cortisone-induced enzymes are simply a function of their normal degradative rate constants.

Tyrosine aminotransferase

Alanine aminotransferase

10.1016/s0026-895x(25)15248-6

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Citations (9)

Survival After Suspension of Perfusion During Asanguineous Cardiopulmonary Bypass

The Annals of Thoracic Surgery (1968)

William A. Neely Joseph L. Haining

Suspension

10.1016/s0003-4975(10)66336-9

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Citations (5)

Adventitial red blood cells produce intimal platelet accumulation in cerebral arteries of cats following subarachnoid hemorrhage.

Stroke (1991)

Yoshihiro Yamamoto Ben R. Clower Joseph L. Haining Shoji Asari Robert R. Smith

After dividing 21 cats into three equal groups, we exposed their right middle cerebral arteries transorbitally and adventitially irrigated them with 2 ml washed red blood cells, blood plasma, or saline. To determine arterial intimal platelet accumulation in each cat, we injected [111In]oxine-labeled platelets intravenously immediately before injecting the various experimental solutions. Animals were sacrificed 2 or 4 hours following the injection of labeled platelets. Irrigation with washed red blood cells produced a significantly greater intraluminal accumulation of platelets than irrigation with saline (p less than 0.05). Plasma tended to have less of an effect on platelet accumulation than washed red blood cells, but this difference was not significant. These data suggest that the adventitial blood fraction responsible for intimal platelet accumulation in cerebral arteries following subarachnoid hemorrhage may be derived mainly from the red blood cell fraction.

10.1161/01.str.22.3.373

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Citations (8)

Measurement of local skeletal muscle blood flow in animals by the hydrogen electrode technique

Muscle & Nerve (1980)

Shri K. Mishra Joseph L. Haining

The hydrogen (H2) electrode technique has been applied to the measurement of local skeletal muscle blood flow (LSMBF) in experimental animals (rats, rabbits, and monkeys). LSMBF was measured during resting and postexercise states, following epinephrine injections and during CO2 inhalation. Among the limited sites studied and/or measurements obtained, significant differences in LSMBF were found in only a few instances. During hypercapnia, LSMBF was found to be increased in some muscles in rats and monkeys. The present study demonstrates that the H2 electrode technique is a simple and reliable method for measuring resting and postexercise LSMBF in anesthetized animals. This method provides measurements at discrete loci, is easily reproducible, and causes little trauma.

10.1002/mus.880030402

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Citations (9)

Constrictive structural elements in human cerebral arteries following aneurysmal subarachnoid haemorrhage

Neurological Research (1987)

Robert R. Smith Ben R. Clower Julius M. Cruse Yutaka Honma Joseph L. Haining

Histoimmunological, histochemical, and histological studies were conducted on cerebral arteries from four living patients with a recent aneurysmal subarachnoid haemorrhage. There appeared to be a correlation between the severity of vasospasm and the magnitude of pathological findings. Large myofibroblast cells and type V collagen within the medial layer were abundant in arteries showing marked vasospasm, but were less conspicuous in those showing milder involvement. Intracranial arteries from patients who died from non-cerebral causes did not demonstrate these changes. In ruptured vessels, there was also a positive fluorescence for actin-myosin filaments in layers of the arterial wall other than the media. It is postulated that the intimal and adventitial actin-myosin, myofibroblasts and type V collagen may contribute to cerebral vasospasm by holding the damaged vessel in a contracted phase during the healing period.

Myofibroblast

Cerebral Vasospasm

Anterior cerebral artery

10.1080/01616412.1987.11739793

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Citations (17)

On the kinetics of liver enzyme regression following induction

Archives of Biochemistry and Biophysics (1971)

Joseph L. Haining

Regression function

Enzyme Kinetics

10.1016/0003-9861(71)90469-3

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Citations (20)