Thannikot M. Jaison

Christian Medical College & Hospital

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K. Srinath Reddy

All India Institute of Medical Sciences

Bijulal Sasidharan

Sree Chitra Thirunal Institute for Medical Sciences and Technology

Nakul Sinha

Medanta The Medicity

Rajeev Gupta

Eternal Hospital

Dorairaj Prabhakaran

Centre for Chronic Disease Control

Dinesh Badyal

Christian Medical College

Panniyammakal Jeemon

Sree Chitra Thirunal Institute for Medical Sciences and Technology

Sandeep Chopra

Apollo Hospitals

Jacob Jose

Ministry of Health

Neha J. Pagidipati

Clinical Research Institute

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Christian Medical College

Christian Medical College & Hospital

All India Institute of Medical Sciences

Public Health Foundation of India

Sree Chitra Thirunal Institute for Medical Sciences and Technology

All India Institute of Medical Sciences Raipur

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Centre for Chronic Disease Control

All India Institute of Medical Sciences Bhopal

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Association between Gender, Process of Care Measures, and Outcomes in ACS in India: Results from the Detection and Management of Coronary Heart Disease (DEMAT) Registry

PLoS ONE (2013)

Neha J. Pagidipati Mark D. Huffman Panniyammakal Jeemon Rajeev Gupta Prakash Chand Negi

Background Studies from high-income countries have shown that women receive less aggressive diagnostics and treatment than men in acute coronary syndromes (ACS), though their short-term mortality does not appear to differ from men. Data on gender differences in ACS presentation, management, and outcomes are sparse in India. Methods and Results The Detection and Management of Coronary Heart Disease (DEMAT) Registry collected data from 1,565 suspected ACS patients (334 women; 1,231 men) from ten tertiary care centers throughout India between 2007–2008. We evaluated gender differences in presentation, in-hospital and discharge management, and 30-day death and major adverse cardiovascular event (MACE; death, re-hospitalization, and cardiac arrest) rates. Women were less likely to present with STEMI than men (38% vs. 55%, p<0.001). Overall inpatient diagnostics and treatment patterns were similar between men and women after adjustment for potential confounders. Optimal discharge management with aspirin, clopidogrel, beta-blockers, and statin therapy was lower for women than men, (58% vs. 65%, p = 0.03), but these differences were attenuated after adjustment (OR = 0.86 (0.62, 1.19)). Neither the outcome of 30-day mortality (OR = 1.40 (0.62, 3.16)) nor MACE (OR = 1.00 (0.67, 1.48)) differed significantly between men and women after adjustment. Conclusions ACS in-hospital management, discharge management, and 30-day outcomes did not significantly differ between genders in the DEMAT registry, though consistently higher treatment rates and lower event rates in men compared to women were seen. These findings underscore the importance of further investigation of gender differences in cardiovascular care in India.

Mace

10.1371/journal.pone.0062061

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Effect of atorvastatin on hs‐CRP in acute coronary syndrome

British Journal of Clinical Pharmacology (2008)

Ankur Gupta Dinesh Badyal Prem Parkash Khosla Bharti Uppal Thannikot M. Jaison

To evaluate the effect of a lower dose (20 mg) of atorvastatin on hs-CRP concentrations in patients with ACS.Group A (n = 50) patients received atorvastatin 20 mg day(-1) for 4 weeks in addition to standard anti-anginal treatment. Group B (n = 50) patients received standard anti-anginal treatment without atorvastatin.hs-CRP concentrations decreased in both groups, but the decrease was greater in group A. The decrease in hs-CRP was also significantly greater in the subgroups of smoking, hypertension and past history of cardiovascular disease with atorvastatin.The use of a lower dose (20 mg) of atorvastatin can offer an attractive approach for early treatment of patients with ACS.

10.1111/j.1365-2125.2008.03172.x

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Citations (11)