V. Del Gobbo

E and EAC rosettes forming lymphocytes were evaluated in 25 elderly subjects (mean age 84.76 years) without manifestations of neoplastic or infectious diseases. The percentage of E rosettes appeared within the normal range in about 50 per cent of cases and below normal in remaining 50 per cent. No evident sex-related differences were observed. The percentage of EAC rosettes showed a larger distribution of values. In fact, 56 per cent of cases fell within normal limits, 26 per cent was higher and 20 per cent lower than normal. Our results are in agreement with the data reported in the most recent literature, which indicates that the main target of immune system senescence is the T-cell population, while B cells do not show significant age-related variations. The significant number of cases with percentages of EAC rosettes higher than normal may be attributed to the failure of immune homeostatic mechanisms normally exerted by T cell subpopulations. Further studies on several immune system functions in advanced age are in progress.

Rosette (schizont appearance)

Senescence

Normal values

Normal population

Rosette formation

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Thymic Factors in Experimental Diseases

Immunoregulation (1983)

Enrico Garaci Francesco Bistoni Cartesio Favalli P Marconi V. Del Gobbo

As a series of methods were available for determination of serum thymic hormone-like activity (Bach and Dardenne, 1973; Astaldi et al., 1976; Lewis et al., 1981), studies were carried out by several researchers in order to determine modifications of thymic activity in different clinical and experimental conditions. This area of investigation has been considered of primary interest in the recent years for the following reasons:

10.1007/978-1-4684-4547-3_13

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Influenza Virus Infection Reduces Cellular Immunity Functions

Advances in experimental medicine and biology (1989)

V. Del Gobbo E Balestra Stefano Marini Nicoletta Villani R Caliò

Immunosuppression

Cellular immunity

10.1007/978-1-4684-5712-4_24

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[Effect of prostaglandins on cellular immune response in mice with melanoma B16].

PubMed (1980)

Cartesio Favalli M.G. Santoro Teresa Jezzi V. Del Gobbo C Rinaldi

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[Preliminary study on the effects induced by an anemic strain of Friend leukemia virus in DBA/2 mice].

PubMed (1980)

V. Del Gobbo Laura Santucci M G Premrov Cartesio Favalli C Rinaldi

Serum thymic factor (STF) and azathioprine (AZ) inhibition test were assayed in sera and spleen cells from DBA/2 and BALB/c mice, inoculated with the anemic strain of Friend leukemia virus. The observed decrease of STF levels appears to be related to the LLV (Lymphatic Leukemia Virus) component of FLV-A.

Friend virus

Strain (injury)

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Papers

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