Pingping Tan

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

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Z. Runlin

Institute of Genetics and Developmental Biology

Liu Ka

Children's Cancer Center

Weiping Ji

Wenzhou Medical University

Yuqing Ran

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Xu Lu

Nantong University

Songwei Qian

Wenzhou Medical University

Xiaoling Guo

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Y Wang

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Chao Huang

Huazhong University of Science and Technology

Yuting Guan

East China Normal University

Cooperative Institutions

Chinese Academy of Sciences

Wenzhou Medical University

Nantong University

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Capital Medical University

Beijing Chao-Yang Hospital

Sun Yat-sen University

Zhejiang University

Peking University

Institute of Genetics and Developmental Biology

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Oral lichenoid lesion simultaneously associated with Castleman’s disease and papillary thyroid carcinoma: a rare case report

BMC Oral Health (2022)

Jiaying Zhou Rui Zhou Pingping Tan Bin Cheng Liwei Ma

Oral lichenoid lesion (OLL) is a term used to describe oral lesions that have clinical and/or histopathological features similar to oral lichen planus (OLP), but it is thought to be caused by specific triggers or systemic conditions and presents higher malignant transformation rate than OLP. To date, OLL simultaneously complicated with Castleman's disease (CD) and papillary thyroid carcinoma (PTC) has not been reported. Reporting from such disorders is crucial to avoid misdiagnosis and help in timely intervention.We report a rare case of a 39-year-old female with extensive ulcerated lesions on the oral mucosa, diagnosed as OLL by histopathology. Routine oral treatment was scheduled to control the OLL, while the oral lesions remained unhealed. Computed tomography examination was performed after the oral treatment and revealed thyroid and mediastinal masses, which were then surgically removed and pathologically diagnosed as PTC and CD, respectively. Two months after complete excision of the neoplasms, the oral lesions showed obvious alleviation. With subsequent treatment for oral lesions, the patient's OLL healed.This is the first reported OLL case simultaneously associated with CD and PTC. This case reminds us to focus on the underlying etiologies of OLL and the multidisciplinary collaboration for oral lesions associated with systemic diseases.

Oral Lichen Planus

Histopathology

Etiology

10.1186/s12903-022-02623-2

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Citations (1)

Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice

Brain Behavior and Immunity (2020)

Yue Gu Ting Ye Pingping Tan Lijuan Tong JI Jian-lin

Social defeat

Chronic Stress

10.1016/j.bbi.2020.11.002

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Citations (44)

TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation

Respiratory Research (2023)

Mingting Wu Zhenyan Wang Xiaoqian Shi Danni Zan Hong Chen

Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic strategies.The lung fibroblasts from IPF patients and Reticulocalbin 3 (RCN3) fibroblast-selective knockdown mouse model were used to determine the importance of Rcn3 in IPF; the epigenetic analysis and protein interaction assays, including BioID, were used for mechanistic studies.Reticulocalbin 3 (RCN3) upregulation is associated with the fibrotic activation of lung fibroblasts from IPF patients and Rcn3 overexpression blunts the antifibrotic effects of pirfenidone and nintedanib. Moreover, repressing Rcn3 expression in mouse fibroblasts ameliorates bleomycin-induced lung fibrosis and pulmonary dysfunction in vivo. Mechanistically, RCN3 promotes fibroblast activation by maintaining persistent activation of TGFβ1 signalling via the TGFβ1-RCN3-TGFBR1 positive feedback loop, in which RCN3 upregulated by TGFβ1 exposure detains EZH2 (an epigenetic methyltransferase) in the cytoplasm through RCN3-EZH2 interaction, leading to the release of the EZH2-H3K27me3 epigenetic repression of TGFBR1 and the persistent expression of TGFBR1.These findings introduce a novel regulating mechanism of TGFβ1 signalling in fibroblasts and uncover a critical role of the RCN3-mediated loop in lung fibrosis. RCN3 upregulation may cause resistance to IPF treatment and targeting RCN3 could be a novel approach to ameliorate pulmonary fibrosis.

Nintedanib

Pirfenidone

10.1186/s12931-023-02533-z

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Citations (5)

Genetic study on the behavior of honeybees influenced by polyandry system

Chinese Science Bulletin (1999)

Yan Ouyang Liming Wu Feng Jin Wei Shi Pingping Tan

Apis cerana

Dendrogram

10.1007/bf02886349

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Handmade Cloned Transgenic Sheep Rich in Omega-3 Fatty Acids

PLoS ONE (2013)

Peng Zhang Peng Liu Hongwei Dou Lei Chen Longxin Chen

Technology of somatic cell nuclear transfer (SCNT) has been adapted worldwide to generate transgenic animals, although the traditional procedure relies largely on instrumental micromanipulation. In this study, we used the modified handmade cloning (HMC) established in cattle and pig to produce transgenic sheep with elevated levels of omega-3 (n-3) fatty acids. Codon-optimized nematode mfat-1 was inserted into a eukaryotic expression vector and was transferred into the genome of primary ovine fibroblast cells from a male Chinese merino sheep. Reverse transcriptase PCR, gas chromatography, and chromosome analyses were performed to select nuclear donor cells capable of converting omega-6 (n-6) into n-3 fatty acids. Blastocysts developed after 7 days of in vitro culture were surgically transplanted into the uterus of female ovine recipients of a local sheep breed in Xinjiang. For the HMC, approximately 8.9% (n =925) of reconstructed embryos developed to the blastocyst stage. Four recipients became pregnant after 53 blastocysts were transplanted into 29 naturally cycling females, and a total of 3 live transgenic lambs were produced. Detailed analyses on one of the transgenic lambs revealed a single integration of the modified nematode mfat-1 gene at sheep chromosome 5. The transgenic sheep expressed functional n-3 fatty acid desaturase, accompanied by more than 2-folds reduction of n-6/n-3 ratio in the muscle (p<0.01) and other major organs/tissues (p<0.05). To our knowledge, this is the first report of transgenic sheep produced by the HMC. Compared to the traditional SCNT method, HMC showed an equivalent efficiency but proved cheaper and easier in operation.

Transgenesis

Cloning (programming)

10.1371/journal.pone.0055941

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Citations (64)

A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice

Neuropharmacology (2021)

JI Jian-lin Haitao Xiang Xu Lu Pingping Tan Rongrong Yang

Minocycline

Chronic Stress

Depression

10.1016/j.neuropharm.2021.108621

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Citations (12)

Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology (2018)

Jiawei Jin Xiaoqian Shi Yongchao Li Qianyu Zhang Yu Amanda Guo

Reticulocalbin 3 (Rcn3) is an endoplasmic reticulum (ER) lumen protein localized to the secretory pathway. We have reported that Rcn3 plays a critical role in alveolar epithelial type II cell maturation during perinatal lung development, but its biological role in the adult lung is largely unknown. In this study, we found marked induction of Rcn3 expression in alveolar epithelium during bleomycin-induced pulmonary fibrosis, which is most obvious in alveolar epithelial type II cells (AECIIs). To further examine Rcn3 in pulmonary injury remodeling, we generated transgenic mice to selectively delete Rcn3 in AECIIs in adulthood. Although Rcn3 deletion did not cause obvious abnormalities in the lung architecture and mechanics, the exposure of Rcn3-deleted mice to bleomycin led to exacerbated pulmonary fibrosis and reduced lung mechanics. These Rcn3-deleted mice also displayed enhanced alveolar epithelial cell (AEC) apoptosis and ER stress after bleomycin treatment, which was confirmed by in vitro studies both in primary AECIIs and mouse lung epithelial cells. Consistently, Rcn3 deficiency also enhanced ER stress and apoptosis induced by ER stress inducers, tunicamycin and thapsigargin. In addition, Rcn3 deficiency caused blunted wound closure capability of AECs, but not altered proliferation and bleomycin-induced epithelial–mesenchymal transition process. Collectively, these findings indicate that bleomycin-induced upregulation of Rcn3 in AECIIs appears to contribute to AECII survival and wound healing. These observations, for the first time, suggest a novel role of Rcn3 in regulating pulmonary injury remodeling, and shed additional light on the mechanism of idiopathic pulmonary fibrosis.

Alveolar Epithelium

10.1165/rcmb.2017-0347oc

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Citations (21)

Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice

Neuropharmacology (2022)

Pingping Tan Ting Xue Yue Wang Zhichao Hu Jianbin Su

Tail suspension test

Cyclic adenosine monophosphate

Chronic Stress

10.1016/j.neuropharm.2022.108990

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Citations (21)

Electrostatically directed assembly of two-dimensional ultrathin Co2Ni-MOF/Ti3C2Tx nanosheets for electrocatalytic oxygen evolution

Journal of Colloid and Interface Science (2022)

Pingping Tan Rongwei Gao Yawei Zhang Ning Han Yinzhu Jiang

Overpotential

Oxygen evolution

Electrolysis of water

10.1016/j.jcis.2022.10.109

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Citations (34)

Hesperidin alleviates endothelial cell inflammation and apoptosis of Kawasaki disease through inhibiting the TLR4/IĸBα/NF-ĸB pathway

Authorea (Authorea) (2024)

Xiaoling Guo Yuting Guan Jinghua Ruan Pingping Tan Songwei Qian

Kawasaki Disease (KD) is an acute and self-limiting vasculitis of unknown etiology that mainly occurs in infancy and can lead to vascular endothelial injury. Hesperidin (HES) is an economical dietary biological flavonoid with anti-oxidant, anti-inflammatory, and anti-apoptotic pharmacological effects. The main objective of this study was to investigate the protective effects of HES on KD, and try to elucidate the underlying mechanism. The Candida albicans water-soluble fraction (CAWS) was used to induce coronary arteritis of KD mouse model in vivo, and tumor necrosis factor α (TNF-α) was employed to induce human umbilical vein endothelial cell (HUVEC) injury of KD cell model in vitro to investigate the anti-inflammatory and anti-apoptotic effects of HES on KD. Our in vivo results showed that HES significantly reduced coronary artery injury in KD mice by alleviating pericoronary inflammatory infiltration and tissue fibrosis, inhibiting inflammatory cytokines and chemokines expressions, and decreasing vascular endothelial cell apoptosis. Our in vitro study confirmed that HES had the opposite ability of the NF-κB agonist NF-ĸB activator 1 (ACT1) to significantly alleviate the inflammatory response, CellROX level, and apoptosis by decreasing BAX/BCL-2 and Cleaved Caspase-3 levels as well as reducing TUNEL positive cells and the ratio of flow cytometry apoptotic cells in TNF-α induced HUVECs. The further mechanism study based on bioinformatics analysis and western blot demonstrated that HES could protect against vascular inflammation and cell apoptosis of KD through inhibiting the TLR4/IĸBα/NF-ĸB pathway, suggesting that HES may be a promising therapeutic candidate for KD.

Proinflammatory cytokine

10.22541/au.173356578.86126752/v1

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