María-Prado Míguez

Universidad de Extremadura

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José‐Enrique O’Connor

Universitat de València

Mercedes Costell

Universitat de València

Santiago Grisolı́a

Generalitat Valenciana

Pedro Martín-Palomino

Universidad de Extremadura

S. Regodón

Universidad de Extremadura

Kai O. Lindros

National Institutes of Health

I. Gasser Laguna

Universidad de Valladolid

Ricardo García-Arroyo

M. Hevia

Universidad de Murcia

Lourdes García-Rubio

Universidad de Extremadura

Cooperative Institutions

Universidad de Extremadura

Universitat de València

Instituto Valenciano de Investigaciones Agrarias

Universidad de Murcia

École Nationale Vétérinaire de Toulouse

National Institutes of Health

Finnish Foundation for Alcohol Studies

Institute for Molecular Medicine Finland

Indiana University – Purdue University Indianapolis

Indiana University School of Medicine

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Cattle mortality due to poisoning in Spain: a cross-sectional epidemiological study

Spanish Journal of Agricultural Research (2015)

Ricardo García-Arroyo María-Prado Míguez M. Hevia A. Quiles

The lack of nationwide public databases on poisoning in cattle makes it difficult to investigate this issue. Hence, we conducted an epidemiological study using the data on cattle poisoning provided by an insurance company (2000-2005), to determine the mortality rate due to poisoning in cattle in Spain and to assess the influence of the following variables: type of farming, age, sex, time of year, year and region. We observed a mortality rate of 23.25 per 100,000 animals in Spain with a higher rate in beef than dairy cattle (32.14 vs. 4.51 per 100,000 animals). There were also differences in the mortality rate between breeding cattle and future breeders, affecting dairy and beef cattle in a different way. In dairy cattle, we found differences between the years analysed. In beef cattle, the time of year with highest risk of poisoning was the last quarter (19.45 per 100,000 animals), while the lowest mortality rate was observed in the first quarter (1.33 per 100,000). There were pronounced differences between regions in beef cattle, differences being non-significant in dairy cattle. Lastly, in beef cattle, no differences were found between sexes. In summary, the mortality rate due to poisoning in cattle in Spain is low, and the risk of poisoning is determined by the farming system, animals’ stage of development, time of year and region.

Beef Cattle

Quarter (Canadian coin)

Cattle Diseases

10.5424/sjar/2015131-6613

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Citations (2)

Influence of the route of administration on the protective effect of l-carnitine on acute hyperammonemia

Biochemical Pharmacology (1986)

José‐Enrique O’Connor Mercedes Costell María-Prado Míguez Santiago Grisolı́a

Weanling

Feedlot

10.1016/0006-2952(86)90407-7

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Citations (22)

Protective effect of melatonin on paraquat-induced cytotoxicity in isolated rat hepatocytes

Human & Experimental Toxicology (2005)

Lourdes García-Rubio Pura Matas María-Prado Míguez

Paraquat (PQ) is a known herbicide that causes acute cell injury by undergoing redox cycling. In previous reports, it has been reported that melatonin reduces PQ-induced hepatic toxicity in vivo, but, at the moment, there is no evidence that this effect occurs in this organ in vitro. In the present study we examined the effect of melatonin on PQ-induced oxidative damage in the liver using a hepatocyte suspension as a biological model. Preincubation of hepatocytes with melatonin (0.5, 1 or 2 mM), 30 min prior to PQ (10 mM) addition, prevented in a dose-and time-dependent manner the loss of viability, the leakage of lactate dehydrogenase, depletion of intra-cellular glutathione and malondialdehyde accumulation induced by the herbicide. Melatonin at the highest dose assayed (2 mM) completely prevented cell damage caused by PQ. These effects of melatonin are similar to those described in studies carried out in vivo. These results confirm that melatonin confers protection against PQ-induced hepatic oxidative stress and show that freshly isolated hepatocyte suspension is an adequate in vitro system for evaluating the cytoprotective effects of melatonin on oxidative injury caused by xenobiotics.

Malondialdehyde

Viability assay

10.1191/0960327105ht548oa

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Citations (19)

Evolution of oxidative/nitrosative stress biomarkers during an open-field vaccination procedure in sheep: Effect of melatonin

Veterinary Immunology and Immunopathology (2009)

Asunción Ramos I. Gasser Laguna María-Luisa Martín de Lucía Pedro Martín-Palomino S. Regodón

10.1016/j.vetimm.2009.06.016

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Citations (15)

Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P450 2E1