Terry Horsburgh

Leicester General Hospital

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P S Veitch

University of Ulster

John Walls

University of Glasgow

John Feehally

University of Leicester

Peter Bell

Leicester Royal Infirmary

Steven J. Harper

Vanderbilt University Medical Center

Michael L. Nicholson

University of Cambridge

Sue Carr

General Medical Council

Jennifer Moorhouse

University of Canberra

Christian Combe

Centre Hospitalier Universitaire de Bordeaux

Adam Jurewicz

University Hospital of Wales

Cooperative Institutions

Leicester General Hospital

University of Leicester

Kyushu University

Newcastle University

Inserm

Kagoshima University

University Hospitals of Leicester NHS Trust

Hospital Universitario Ramón y Cajal

University of Cambridge

Tokyo Medical and Dental University

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IMPROVED IMMEDIATE GRAFT FUNCTION WITH NIFEDIPINE IN CYCLOSPORINE-TREATED RENAL ALLOGRAFT RECIPIENTS—A RANDOMIZED PROSPECTIVE STUDY

Transplantation (1992)

Steven J. Harper Jennifer Moorhouse P S Veitch Peter Bell Terry Horsburgh

HARPER, STEVEN J.; MOORHOUSE, JENNIFER; VEITCH, PETER S.; BELL, PETER R. F.; HORSBURGH, TERRY; WALLS, JOHN; DONNELLY, PETER K.; FEEHALLY, JOHN Author Information

10.1097/00007890-199210000-00037

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Citations (14)

The application of flow cytometry to histocompatibility testing

Transplant Immunology (2000)

Terry Horsburgh Susan Martin Amanda Robson

Histocompatibility

10.1016/s0966-3274(00)00006-x

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Citations (27)

The beneficial effects of oral nifedipine on cyclosporin-treated renal transplant recipients ? a randomised prospective study

Transplant International (1996)

Steven J. Harper Jennifer Moorhouse Keith R. Abrams Adam Jurewicz Michael Nicholson

Group B

Regimen

Group A

Nephrology

10.1007/bf00336388

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Citations (28)

The beneficial effects of oral nifedipine on cyclosporin-treated renal transplant recipients — a randomised prospective study

Transplant International (1996)

Steven J. Harper Jennifer Moorhouse Keith R. Abrams Adam Jurewicz Michael L. Nicholson

Group B

Regimen

Ciclosporin

Nephrology

Group A

10.1111/j.1432-2277.1996.tb00865.x

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Citations (21)

Receptor-Mediated Endocytosis of Low-Density Lipoprotein by Cultured Human Glomerular Cells

The Nephron journals/Nephron journals (1990)

Hugh C. Rayner Terry Horsburgh Sally L. Brown Louise Lavender A F Winder

Lipoproteins might be involved in the pathogenesis of glomerular damage. Uptake of low-density lipoprotein (LDL) by cultured human glomerular cells has been studied using LDL, labelled with the fluorescent probe 1, 1'-dioctadecyl-3,3,3'3'-tetramethyl-indocarbocyanine perchlorate (dil). Cells have been characterised using phase-contrast microscopy, monoclonal antibodies and lectins. Differentiated glomerular epithelial cells, epithelial-like cells and mesangial cells all took up dil-LDL. Uptake was specific for LDL, of high affinity and inhibited by excess unlabelled LDL, heparin and preloading the cells with cholesterol. Binding of dil-LDL to the cell surface was restricted to discrete areas which were arranged in linear arrays on mesangial cells. Endocytosis of surface-bound dil-LDL occurred within 3 min and breakdown of internalised dil-LDL within 30 min. These results indicate that cultured human glomerular cells take up LDL by receptor-mediated endocytosis.

Mesangial cell

Low-density lipoprotein

Renal glomerulus

10.1159/000185978

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Citations (17)

A comparison of the results of renal transplantation from non–heart-beating, conventional cadaveric, and living donors

Kidney International (2000)

Michael L. Nicholson Matthew S. Metcalfe Steven A. White J R Waller T Doughman

Brain dead

Cadaveric spasm

Nephrology

Economic shortage

10.1046/j.1523-1755.2000.00445.x

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Citations (205)

EVALUATION OF THE FLOW CYTOMETRIC CROSSMATCH

Transplantation (1996)

Andrea W. Harmer Stephen F. Garner Alison Bell Chinyere Anyanwu G. Cavanagh

The flow cytometric crossmatch is a technique that is increasingly being used by clinical transplant laboratories. In this multicenter study by the British Society for Histocompatibility and Immunogenetics Flow Cytometry Group, a series of crossmatches were carried out to determine whether different centers obtained the same results when performing the same crossmatch. There was greater than 80% agreement among participating laboratories on the results of 34/54 tests. There was no clear agreement in the remaining 20 cases. Quantitative analysis, estimating the number of cell-bound fluorescein molecules, demonstrated that differences in the criteria used by each center to define a positive crossmatch were responsible for some of the discordant results. When applied, definition of positivity based on molecules of fluorescein increased concordance from 57.5% to 81.4%. These results suggest that a criterion for the interpretation of results based on quantitative analysis of bound antibody may be more reliable than methods in current routine use.

Concordance

Histocompatibility

10.1097/00007890-199604150-00021

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Citations (14)

Workload generated by a living donor programme for renal transplantation

Nephrology Dialysis Transplantation (2000)

Richard N. Saunders Rosemary Elwell Gavin J. Murphy Terry Horsburgh Sue Carr

The ethical and medical implications of live kidney donation result in a comprehensive work-up process. The aim of this study was to determine the magnitude of the workload and the yield of renal transplants generated by a live donor programme.Referrals to the Leicester live donor programme over the five-year period 1994-1998 were retrospectively assessed. These were initiated by nephrology referral and subsequently investigated in a stepwise manner. Patients were counselled and baseline tests performed prior to consultant surgeon review and assessment of donor renal function/anatomy.One hundred and fifty referrals consisting of 150 recipients with 269 potential donors were originally made. This resulted in 32/120 (27%) related and 3/30 (10%) unrelated recipients (P=0.06) and 32/220 (15%) related and 3/49 (6%) unrelated donors proceeding to live donor transplantation, with a mean work-up time (+/-SD) of 9 (+/-7) months. One hundred and fifteen recipients (77%) and 234 (87%) donors failed to proceed at various stages of assessment, for a variety of immunological, medical and social reasons. A large number of expensive immunological investigations were required for potential donors, the majority of which did not proceed to transplantation. However as a result of performing these in the early stages of assessment the number of more invasive tests is kept to a minimum.There is a relatively low yield of transplants from live donor referrals, particularly those between unrelated individuals. The vast majority of referrals fail to proceed for legitimate reasons, but as a result, create a significant workload with notable staffing and financial implications.

Nephrology

Live donor

10.1093/ndt/15.10.1667

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Citations (22)

A simple, rapid, reliable reverse haemolytic plaque assay and positive quality control test for routine use

Journal of Immunological Methods (1985)

Harriet Hall Terry Horsburgh P S Veitch A. Sidgwick Peter Bell

Agarose

Virus quantification

Bradford protein assay

Pokeweed mitogen